Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity

European Journal of Medicinal Chemistry

Volumn 41, Issue 6, 2006, Pages 727-737

  Dubinina, G G ^a   Platonov, M O ^a   Golovach, S M ^a   Borysko, P O ^a   Tolmachov, A O ^a   Volovenko, Y M ^a  

^a TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

Author keywords

Antiproliferative agents; Cytostatic agents; Docking; Kinase inhibitor; Molecular modeling; Pyrrolo 2,3 b pyrazine

Indexed keywords

5 (4 CHLOROBENZYL) 6 AMINO 7 (1 METHYL 1H BENZ[D]IMIDAZOL 2 YL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 5 (4 FLUOROBENZYL) 6 AMINO 7 (1 METHYL 1H BENZ[D]IMIDAZOL 2 YL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (2 DIETHYLAMINO)ETHYL 7 (1 METHYL 1H BENZ[D]IMIDAZOL 2 YL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (2 DIETHYLAMINO)ETHYL 7 (PHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (3 CHLOROPHENYLAMINO) 7 (1 METHYL 1H BENZ[D]IMIDAZOL 2 YL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (3,4 DIMETHOXYPHENETHYL) 7 (4 CHLOROPHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (4 CHLOROBENZYL) 7 (PHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (4 ETHOXYPHENYL) 7 (PHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (4 METHOXYBENZYL) 7 (4 CHLOROPHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (4 METHOXYBENZYL) 7 (PHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (4 METHYBENZYL) 7 (PHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (BENZO[D][1,3]DIOXOL 5 YLMETHYL) 7 (1 METHYL 1H BENZO[D]IMIDAZOL 2 YL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 (BENZO[D][1,3]DIOXOL 5 YLMETHYL) 7 (PHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 PHENETHYL 7 (4 CHLOROPHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; 6 AMINO 5 PHENETHYL 7 (PHENYLSULFONYL) 5H PYRROLO[3,2 B]PYRAZINE 2,3 DICARBONITRILE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE; PROTEIN KINASE INHIBITOR; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; KIDNEY CANCER; MOLECULAR MODEL; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZINES; SPECTROPHOTOMETRY, INFRARED;

EID: 33744990579     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.03.019     Document Type: Article

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