Protein kinase A targeting and activation as seen by small-angle solution scattering

European Journal of Cell Biology

Volumn 85, Issue 7, 2006, Pages 655-662

  Trewhella, Jill ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Neutron contrast variation; Protein kinase A; Small angle scattering; Structure; X ray scattering

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; ISOENZYME;

CATALYSIS; CRYSTAL STRUCTURE; DATA ANALYSIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; MOLECULAR MODEL; NEUTRON SCATTERING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 33744988383     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2006.01.003     Document Type: Review

References (30)

1. Amieux P.S., and McKnight G.S. The essential role of RI alpha in the maintenance of regulated PKA activity. Ann NY Acad. Sci. 968 (2002) 75-95
2. Banky P., Roy M., Newlon M.G., Morikis D., Haste N.M., Taylor S.S., and Jennings P.A. Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. J. Mol. Biol. 330 (2003) 1117-1129
3. Canaves J.M., and Taylor S.S. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J. Mol. Evol. 54 (2002) 17-29
4. Cummings D.E., Brandon E.P., Planas J.V., Motamed K., Idzerda R.L., and McKnight G.S. Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 382 (1996) 622-626
5. Diller T.C., Madhusudan, Xuong N.H., and Taylor S.S. Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type IIβ regulatory subunit. Structure 9 (2001) 73-82
6. Gangal M., Clifford T., Deich J., Cheng X., Taylor S.S., and Johnson D.A. Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc. Natl. Acad. Sci. USA 96 (1999) 12394-12399
7. Heller W.T., Krueger J.K., and Trewhella J. Further insights into calmodulin-myosin light chain kinase interaction from solution scattering and shape restoration. Biochemistry 42 (2003) 10579-10588
8. Heller W.T., Vigil D., Brown S., Blumenthal D.K., Taylor S.S., and Trewhella J. C subunits binding to the protein kinase A RIα dimer induces a large conformational change. J. Biol. Chem. 279 (2004) 19084-19090
9. Johnson D.A., Leathers V.L., Martinez A.M., Walsh D.A., and Fletcher W.H. Fluorescence resonance energy transfer within a heterochromatic cAMP-dependent protein kinase holoenzyme under equilibrium conditions. Biochemistry 32 (1993) 6402-6410
10. Kandel E. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294 (2001) 5544
11. Kim C., Xuong N.H., and Taylor S.S. Crystal structure of a complex between the catalytic and regulatory (RIα) subunits of PKA. Science 307 (2005) 690-696
12. Knighton D.R., Zheng J.H., Ten Eyck L.F., Ashford V.A., Xuong N.H., Taylor S.S., and Sowadski J.M. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253 (1991) 407-414
13. Kopperud R., Christensen A.E., Kjœrland E., Viste K., Kleivdal H., and Døskeland S.O. Formation of inactive cAMP-saturated holoenzyme of cAMP-dependent protein kinase under physiological conditions. J. Biol. Chem. 277 (2002) 13443-13448
14. Langeberg L.K., and Scott J.D. A-kinase-anchoring proteins. J. Cell Sci. 118 (2005) 3217-3220
15. Newlon M.G., Roy M., Morikis D., Hausken Z.E., Coghlan V., Scott J.D., and Jennings P.A. The molecular basis for protein kinase A anchoring revealed by solution NMR. Nat. Struct. Biol. 6 (1999) 222-227
16. Olah G.A., Mitchell R., Sosnick T.R., Walsh D.A., and Trewhella J. The solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding of the protein kinase inhibitor peptide. Biochemistry 32 (1993) 3649-3657
17. Rao Y., Fischer Q.S., Yang Y., McKnight G.S., LaRue A., and Daw N.W. Reduced ocular dominance plasticity and long-term potentiation in the developing visual cortex of protein kinase A RII alpha mutant mice. Eur. J. Neurosci. 20 (2004) 837-842
18. Su Y., Dostmann W.R., Herberg F.W., Durick K., Xuong N.H., Ten Eyck L., Taylor S.S., and Varughese K.I. Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science 269 (1995) 807-813
19. Tasken K., and Aandahl E.M. Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol. Rev. 84 (2004) 137-167
20. Trewhella J., Gallagher S.C., Krueger J.K., and Zhao J. Neutron and X-ray solution scattering provide insights into biomolecular structure and function. Sci. Progr. 81 (1998) 102-122
21. Tung C.S., Walsh D.A., and Trewhella J. A structural model of the catalytic subunit-regulatory subunit dimeric complex of the cAMP-dependent protein kinase. J. Biol. Chem. 277 (2002) 12423-12431
22. Vigil D., Blumenthal D.K., Brown S., Taylor S.S., and Trewhella J. Differential effect of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry 43 (2004) 5629-5636
23. Vigil D., Blumenthal D.K., Heller W.T., Brown S., Canaves J.M., Taylor S.S., and Trewhella J. Conformational differences among solution structures of the type Iα, IIα and IIβ protein kinase A regulatory subunit homodimers: role of the linker regions. J. Mol. Biol. 337 (2004) 1183-1194
24. Vigil D., Blumenthal D.K., Taylor S.S., and Trewhella J. The conformationally dynamic C helix of the RIα-subunit of protein kinase A mediates isoform specific domain reorganization upon C subunit binding. J. Biol. Chem. 280 (2005) 35521-35527
25. Vigil D., Blumenthal D.K., Taylor S.S., and Trewhella J. Major differences in global architecture of type II PKA isoforms: implications for signaling specificity. J. Mol. Biol. (2006) in press
26. Wall M.E., Gallagher S.C., and Trewhella J. Large-scale shape changes in proteins and macromolecular complexes. Annu. Rev. Phys. Chem. 51 (2000) 355-380
27. Walsh D.A., Glass D.B., and Mitchell R.D. Substrate diversity of the cAMP-dependent protein kinase: regulation based on multiple binding interactions. Curr. Opin. Cell Biol. 4 (1992) 241-251
28. Wong W., and Scott J.D. AKAP signalling complexes: focal points in space and time. Nat. Rev. Mol. Cell Biol. 5 (2004) 959-970
29. Yang S., Fletcher W.H., and Johnson D.A. Regulation of cAMP-dependent protein kinase: enzyme activation without dissociation. Biochemistry 34 (1995) 6267-6271
30. Zhao J., Hoye E., Boylan S., Walsh D.A., and Trewhella J. Quaternary structures of a catalytic subunit-regulatory subunit dimeric complex and the holoenzyme of the cAMP-dependent protein kinase by neutron contrast variation. J. Biol. Chem. 273 (1998) 30448-30459