Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer

Oncology Reports

Volumn 15, Issue 5, 2006, Pages 1281-1285

  Chen, Hong ^a,b   Suzuki, Makoto ^a,c   Nakamura, Yohko ^a   Ohira, Miki ^a   Ando, Soichiro ^a   Iida, Tomohiko ^a   Nakajima, Takahiro ^a   Nakagawara, Akira ^a   Kimura, Hideki ^a  

^a CHIBA CANCER CENTER   (Japan)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Lung cancer; Methylation; RASGRF2; RASSF1A

Indexed keywords

AZACITIDINE; ENZYME INHIBITOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RASGRF2 PROTEIN, HUMAN; RASSF1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

AGED; ARTICLE; CANCER STAGING; CELL CULTURE; COMPARATIVE STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; LUNG; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MALE; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; AZACITIDINE; CARCINOMA, NON-SMALL-CELL LUNG; CELLS, CULTURED; DNA METHYLATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; LUNG; LUNG NEOPLASMS; MALE; NEOPLASM STAGING; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 33744974059     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.5.1281     Document Type: Article

References (20)

1. Kohno T and Yokoto J: How many tumor suppressor genes are involved in human lung carcinogenesis? Carcinogenesis 20: 1403-1410, 1999. (Pubitemid 29385422)
2. Brauch H, Johnson B, Hovis J, Yano T, Gazdar A, Pettengill OS, Graziano S, Sorenson GD, Poiesz BJ and Minna J: Molecular analysis of the short arm of chromosome 3 in small cell and nonsmall cell carcinoma of the lung. N Engl J Med 317: 1109-1113, 1987. (Pubitemid 17156740)
3. Dammann R, Li C, Yoon JH, Chin PL, Bates S and Pfeifer GP: Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 25: 315-319, 2000. (Pubitemid 30437320)
4. Pfeifer GP, Yoon JH, Liu L, Tommasi S, Wilczynski SP and Dammann R: Methylation of the RASSF1A gene in human cancers. Biol Chem 383: 907-914, 2002. (Pubitemid 34874094)
5. Burbee DG, Forgacs E, Zochbauer-Muller S, Shivakumar L, Fong K, Gao B, Randle D, Kondo M, Virmani A, Bader S, Sekido Y, Latif F, Milchgrub S, Toyooka S, Gazdar AF, Lerman MI, Zabarovsky E, White M and Minna JD: Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst 93: 691-699, 2001. (Pubitemid 32492810)
6. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP and Avruch J: The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene 21: 1381-1390, 2002. (Pubitemid 34214503)
7. Shivakumar L, Minna J, Sakamaki T, Pestell R and White MA: The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol Cell Biol 22: 309-318, 2002.
8. Anborgh PH, Qian X, Papageorge AG, Vass WC, deClue JE and Lowy DR: Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol Cell Biol 19: 4611-4622, 1999. (Pubitemid 29289499)
9. Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Munoz MT, Egea G, Lafarga M and Crespo P: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol Cell Biol 24: 1516-1530, 2004. (Pubitemid 38167075)
10. Qiu C, Yu M, Shan L and Snyderwine EG: Allelic imbalance and altered expression of genes in chromosome 2q11-2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine. Oncogene 22: 1253-1260, 2003. (Pubitemid 36363390)
11. Hagihara A, Miyamoto K, Furuta J, Hiraoka N, Wakazono K, Seki S, Fukushima S, Tsao MS, Sugimura T and Ushijima T: Identification of 27 5′ CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene 23: 8705-8710, 2004. (Pubitemid 39576479)
12. Girard L, Zochbauer-Muller S, Virmani AK, Gazdar AF and Minna JD: Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 60: 4894-4906, 2000.
13. Suzuki M, Toyooka S, Miyajima K, Iizasa T, Fujisawa T, Bekele NB and Gazdar AF: Alterations in the mitochondrial displacement loop in lung cancers. Clin Cancer Res 9: 5636-5641, 2003. (Pubitemid 37499485)
14. Zochbauer-Muller S, Minna JD and Gazdar AF: Aberrant DNA methylation in lung cancer: biological and clinical implications. Oncologist 7: 451-457, 2002. (Pubitemid 35266138)
15. Leblanc V, Delumeau I and Tocque B: Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells. Oncogene 18: 4884-4889, 1999. (Pubitemid 29423572)
16. Yang JY and Widmann C: The RasGAP N-terminal fragment generated by caspase cleavage protects cells in a Ras/PI3K/Aktdependent manner that does not rely on NFkappa B activation. J Biol Chem 277: 14641-14646, 2002.
17. Suzuki M, Sunaga N, Shames DS, Toyooka S, Gazdar AF and Minna JD: RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells. Cancer Res 64: 3137-3143, 2004. (Pubitemid 38581414)
18. Tomizawa Y, Kohno T, Kondo H, Otsuka A, Nishioka M, Niki T, Yamada T, Maeshima A, Yoshimura K, Saito R, Minna JD and Yokota J: Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin Cancer Res 8: 2362-2368, 2002. (Pubitemid 34753611)
19. Wang J, Lee JJ, Wang L, Liu DD, Lu C, Fan YH, Hong WK and Mao L: Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer. Clin Cancer Res 10: 6119-6125, 2004. (Pubitemid 39287517)
20. Toyooka S, Suzuki M, Maruyama R, Toyooka KO, Tsukuda K, Fukuyama Y, Iizasa T, Aoe M, Date H, Fujisawa T, Shimizu N and Gazdar AF: The relationship between aberrant methylation and survival in non-small cell lung cancers. Br J Cancer 91: 771-774, 2004. (Pubitemid 39141639)