CD4+ T lymphocytes injected into severe combined immunodeficient (SCID) mice lead to an inflammatory and lethal bowel disease

Clinical and Experimental Immunology

Volumn 104, Issue 3, 1996, Pages 491-500

  Claesson, M H ^b   Rudolphi, A ^a   Kofoed, S ^b   Poulsen, S S ^b   Reimann, J ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Inflammatory bowel disease; SCID mouse; T cells

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN M; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; ENTERITIS; IMMUNOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030024174     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.48757.x     Document Type: Article

References (21)

1. Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature 1983; 301:527-30.
2. Reimann J, Rudolphi A, Claesson MH. Selective reconstitution of T lumphocyte subsets in seid mice, Immunol Rev 1991; 124:75-95.
3. + T cells with an unusual recirculation pattern and a diverse T cell receptor-Vβ repertoire into scid mice. Eur J Immunol 1993; 23:250-6.
4. Yoshikai Y, Ishida A, Murosaki S, Anto T, Nomoto K. Sequential appearance of T-cell receptor γδ- and αβ-bearing intestinal intra-epithelial lymphocytes in mice after irradiation. Immunology 1991; 74:583-8.
5. Boll G, Rudolphi A, Spiess S, Reimann J. Regional specialization of intraepithelial T cells in the murine small and large intestine. Scand J Immunol 1995; 41:103-13.
6. + T cells in the pathogenesis of murine inflammatory bowel disease. Eur J Immunol 1994; 24:2803-12.
7. + T cells. J Exp Med 1993; 178:237-44.
8. + T cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int Immunol 1993; 5:1461-71.
9. low CD4 T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994; 179:589-600.
10. Boll G, Reimann J. Lamina propria T cell subsets in the small and large intestine of euthymic and athymic mice. Scand J Immunol 1995; 42:191-201.
11. MacDonald TT, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exo Med 1988; 167:1341-9.
12. Lionetti P, Breese E, Braegger CP, Murch SH, Taylor J, MacDonald TT. T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine. Gastroenterology 1993; 105:373-81.
13. MacDonald TT, Ferguson A. Hypersensitivity reactions in the small intestine. III. The effects of allograft rejection and of graft-versus-host disease on epithelial cell kinetics. Cell Tissue Kinet 1977; 10:301-12.
14. + T cells. Immunity 1994; 1:553-62.
15. Riggs JE, Stowers RS, Mosier DE. Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immunodeficiency. J Exp Med 1991; 173:265-9.
16. + CD8 T cells from spleen, lymph nodes or thymus of adult dm2 donor mice into young scid mice rescues host-derived, IgM-producing B cells. Immunology 1992; 77:157-64.
17. Hardy RR, Hayakawa K. CD5 B cells, a fetal B cell lineage. Adv Immunol 1994; 55:297-339.
18. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75:253-61.
19. Kühn R, Löhler J, Renneick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75:263-74.
20. Mobaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Tonogawa S. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993; 75:275-82.
21. Halstensen TS, Das KM, Brandtzaeg P. Epithelial deposits of immunoglobulin IgGI and activated complement colocalise with the M40-kD putative autoantigen in ulcerative colitis. Gut 1993; 34:650-7.