Synthesis and evaluation of radioiodinated (S,S)-2-(α-(2-iodophenoxy) benzyl)morpholine for imaging brain norepinephrine transporter

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 33, Issue 6, 2006, Pages 639-647

  Kanegawa, Naoki ^a   Kiyono, Yasushi ^b   Kimura, Hiroyuki ^a   Sugita, Taku ^a   Kajiyama, Satomi ^a   Kawashima, Hidekazu ^a   Ueda, Masashi ^c   Kuge, Yuji ^a   Saji, Hideo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

(S,S) 2 (a (2 iodo phenoxy)benzyl)morpholine; Brain; Norepinephrine transporter; Radioiodination; SPECT

Indexed keywords

2 [ALPHA(IODOPHENOXY)BENZYL]MORPHOLINE I 123; 2 [ALPHA(IODOPHENOXY)BENZYL]MORPHOLINE I 125; DOPAMINE TRANSPORTER; HALOGEN; NISOXETINE; NORADRENALIN TRANSPORTER; RADIOPHARMACEUTICAL AGENT; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN MEMBRANE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG UPTAKE; MALE; MARMOSET; NEUROIMAGING; NONHUMAN; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; CEREBRAL CORTEX; DRUG EVALUATION, PRECLINICAL; ISOTOPE LABELING; MALE; METABOLIC CLEARANCE RATE; MORPHOLINES; ORGAN SPECIFICITY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC; TISSUE DISTRIBUTION;

EID: 33744950624     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-005-0017-y     Document Type: Article

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