Apoptosis and caspase-3 in long-term renal ischemia/reperfusion injury in rats and divergent effects of immunosuppressants

Transplantation

Volumn 81, Issue 10, 2006, Pages 1442-1450

  Yang, Bin ^a,c   Jain, Sunjay ^b   Ashra, Shairbanu Y ^a   Furness, Peter N ^a   Nicholson, Michael L ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Caspase 3; Immunosuppressants; Ischemia reperfusion injury

Indexed keywords

CASPASE 3; CYCLOSPORIN A; DNA FRAGMENT; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY FUNCTION; KIDNEY INTERSTITIUM; KIDNEY ISCHEMIA; KIDNEY PERFUSION; KIDNEY STRUCTURE; KIDNEY TUBULE; MALE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; STATISTICAL SIGNIFICANCE; UNINEPHRECTOMY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; GENE EXPRESSION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY TRANSPLANTATION; MALE; RATS; RATS, WISTAR; REPERFUSION INJURY; RNA, MESSENGER;

EID: 33744935778     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000209412.77312.69     Document Type: Article

References (48)

1. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
2. Gueler F, Gwinner W, Schwarz A. Long-term effects of acute ischemia and reperfusion injury. Kidney Int 2004; 66: 523.
3. Merville P. Combating chronic renal allograft dysfunction: optimal immunosuppressive regimens. Drugs 2005; 65: 615.
4. Nicholson ML, Metcalfe MS, White SA, et al. A comparison of the results of renal transplantation from non-heart-beating, conventional cadaveric, and living donors. Kidney Int 2000; 58: 2585.
5. Columbano A. Cell death: current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo. J Cell Biochem 1995; 58: 181.
6. Daemen MA, de Vries B, Buurman WA. Apoptosis and inflammation in renal reperfusion injury. Transplantation 2002; 73: 1693.
7. Kaushal GP, Basnakian AG, Shah SV. Apoptotic pathways in ischemic acute renal failure. Kidney Int 2004; 66: 500.
8. Hughes J, Savill JS. Apoptosis in glomerulonephritis. Curr Opin Nephrol Hypertens 2005; 14: 389.
9. Launay S, Hermine O, Fontenay M, et al. Vital functions for lethal caspases. Oncogene 2005; 24: 5137.
10. Shihab FS, Andoh TF, Tanner AM, et al. Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis. Kidney Int 1999; 56: 2147.
11. Asai A, Qiu J, Narita Y, et al. High level calcineurin activity predisposes neuronal cells to apoptosis. J Biol Chem 1999; 274: 34450.
12. Herr I, Martin-Villalba A, Kurz E, et al. Tacrolimus prevents stroke-induced generation of ceramide and apoptosis signaling. Brain Res 1999; 826: 210.
13. Yang CW, Ahn HJ, Han HJ, et al. Pharmacological preconditioning with low-dose cyclosporine or tacrolimus reduces subsequent ischemia/reperfusion injury in rat kidney. Transplantation 2001; 72: 1753.
14. Lieberthal W, Fuhro R, Andry CC, et al. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 2001; 281: F693.
15. Eugui EM, Almquist SJ, Muller CD, et al. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand J Immunol 1991; 33: 161.
16. Gregory CR, Pratt RE, Huie P, et al. Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. Transplant Proc 1993; 25: 770.
17. Badid C, Vincent M, McGregor B, et al. Mycophenolate mofetil reduces myofibroblast infiltration and collagen III deposition in rat remnant kidney. Kidney Int 2000; 58: 51.
18. Yang B, El Nahas AM, Thomas GL, et al. Caspase-3 and apoptosis in experimental chronic renal scarring. Kidney Int 2001; 60: 1765.
19. Yang B, Johnson TS, Thomas GL, et al. Apoptosis and caspase-3 in experimental anti-glomerular basement membrane nephritis. J Am Soc Nephrol 2001; 12: 485.
20. Yang B, Johnson TS, Thomas GL, et al. Expression of apoptosis-related genes and proteins in experimental chronic renal scarring. J Am Soc Nephrol 2001; 12: 275.
21. Thornberry NA. The caspase family of cysteine proteases. Br Med Bull 1997; 53: 478.
22. Rudel T. Caspase inhibitors in prevention of apoptosis. Herz 1999; 24:236.
23. Krajewska M, Wang HG, Krajewski S, et al. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase-3), a cell death protease. Cancer Res 1997; 57: 1605.
24. Jain S, Bicknell GR, Nicholson ML. Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury. Br J Surg 2000; 87: 1563.
25. Jain S, Bicknell GR, Whiting PH, et al. Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury. Transplant Proc 2001; 33: 556.
26. Weight SC, Furness PN, Nicholson ML. New model of renal warm ischaemia-reperfusion injury for comparative functional, morphological and pathophysiological studies. Br J Surg 1998; 85: 1669.
27. Ysebaert DK, De Greet KE, Vercauteren SR, et al. Effect of immunosuppression on damage, leukocyte infiltration, and regeneration after severe warm ischemia/repertusion renal injury. Kidney Int 2003; 64: 864.
28. Sun DF, Fujigaki Y, Fujimoto T, et al. Mycophenolate mofetil inhibits regenerative repair in uranyl acetate-induced acute renal failure by reduced interstitial cellular response. Am J Pathol 2002; 161: 217.
29. Donoghue S, Baden HS, Lauder I, et al. Immunohistochemical localization of caspase-3 correlates with clinical outcome in B-cell diffuse large-cell lymphoma. Cancer Res 1999; 59: 5386.
30. Gavrieli Y, Sherman Y, Ben Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493.
31. Thomas GL, Yang B, Wagner BE, et al. Cellular apoptosis and proliferation in experimental renal fibrosis. Nephrol Dial Transplant 1998; 13:2216.
32. Liao J, Xu X, Wargovich MJ. Direct reprobing with anti-beta-actin antibody as an internal control for western blotting analysis. Biotechniques 2000; 28: 216.
33. Waller JR, Murphy GJ, Bicknell GR, et al. Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia. Br J Surg 2002; 89: 1390.
34. Grimm PC, Nickerson P, Gough J, et al. Computerized image analysis of Sirius Red-stained renal allograft biopsies as a surrogate marker to predict long-term allograft function. J Am Soc Nephrol 2003; 14: 1662.
35. Saunders RN, Bicknell GR, Nicholson ML. The impact of cyclosporine dose reduction with or without the addition of rapamycin on functional, molecular, and histological markers of chronic allograft nephropathy. Transplantation 2003; 75: 772.
36. Yang B, Johnson TS, Haylor JL, et al. Effects of caspase inhibition on the progression of experimental glomerulonephritis. Kidney Int 2003; 63:2050.
37. Daemen MA, van't Veer C, Denecker G, et al. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 1999; 104: 541.
38. Wolfs TG, de Vries B, Walter SJ, et al. Apoptotic cell death is initiated during normothermic ischemia in human kidneys. Am J Transplant 2005; 5: 68.
39. Kunduzova OR, Escourrou G, Seguelas MH, et al. Prevention of apoptotic and necrotic cell death, caspase-3 activation, and renal dysfunction by melatonin after ischemia/reperfusion. FASEB J 2003; 17: 872.
40. Esposito C, Fornoni A, Cornacchia F, et al. Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney Int 2000; 58: 123.
41. Miwa K, Asano M, Horai R, et al. Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand. Nature Med 1998; 4: 1287.
42. Shi Y, Melnikov VY, Schrier RW, et al. Downregulation of the calpain inhibitor protein calpastatin by caspases during renal ischemia-reperfusion. Am J Physiol Renal Physiol 2000; 279: F509.
43. Nakamura M, Ogawa N, Shalabi A, et al. Positive effect on T-cell regulatory apoptosis by mycophenolate mofetil. Clin Transplant 2001; 15:36.
44. Daniel C, Duffield J, Brunner T, et al. Matrix metalloproteinase inhibitors cause cell cycle arrest and apoptosis in glomerular mesangial cells. J Pharmacol Exp Ther 2001; 297: 57.
45. Faubel S, Edelstein CL. Caspases as drug targets in ischemic organ injury. Curr Drug Targets Immune Endocr Metabol Disord 2005; 5: 269.
46. Kunduzova OR, Escourrou G, De La Farge F, et al. Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. J Am Soc Nephrol 2004; 15: 2152.
47. Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 2003; 14(suppl 1):S55.
48. Fellstrom B, Zezina L. Apoptosis: friend or foe? Transplant Proc 2001; 33: 2414.