A way to manage the thermal flexibility of ligand candidates for bioassays

Tetrahedron

Volumn 62, Issue 29, 2006, Pages 6754-6761

  Altamura, Maria ^a   Balacco, Giuseppe ^a   Cuda, Francesco ^b   Guerri, Annalisa ^b   Guidi, Antonio ^a   Meini, Stefania ^a   Menichetti, Stefano ^b   Nativi, Cristina ^b   Pasqui, Franco ^a  

^a Menarini Ricerche SpA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; LIGAND; THIOAMIDE;

ARTICLE; BIOASSAY; CHEMICAL MODEL; CONFORMATION; GEOMETRY; MOLECULAR STABILITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL; SOLUTION AND SOLUBILITY; STEREOCHEMISTRY; SUBSTITUTION REACTION; TEMPERATURE; X RAY ANALYSIS;

EID: 33744923463     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.05.011     Document Type: Article

References (21)

1. Dapporto P., Guerri A., Paoli P., Rossi P., Altamura M., Calabri F.R., and Guidi A. J. Mol. Struct. (THEOCHEM) 617 (2002) 189-199
2. Altamura M., Coppini G., Cuda F., Dapporto P., Guerri A., Guidi A., Nativi C., Paoli P., and Rossi P. J. Mol. Struct. 749 (2005) 20-30
3. Guidi, A.; Pasqui, F.; Altamura, M.; Maggi, C. A. WO 2,002,020,437;
4. Chem. Abstr. 136 (2002) 247191
5. Altamura M., Canfarini F., Catalioto R.-M., Guidi A., Pasqui F., Renzetti A.M., Triolo A., and Maggi C.A. Bioorg. Med. Chem. Lett. 12 (2002) 2945-2948
6. Schneider H.-J., Kasper C., Palyulin V., and Samoshin V.V. Supramol. Chem. 8 (1997) 225-229
7. Clayden J., Pink J.H., and Yasin S.A. Tetrahedron Lett. 39 (1998) 105-108
8. Ahmed A., Bragg R.A., Clayden J., Lay L.W., McCarthy C., Pink J.H., Westlund N., and Yasin S.A. Tetrahedron 54 (1998) 13277-13294
9. Ach D., Reboul V., and Metzner P. Eur. J. Org. Chem. (2003) 3398-3406
10. Reist M., Testa B., Carrupt P.-A., Jung M., and Schurig V. Chirality 7 (1995) 396-400
11. Kim Y.-K., Arai M.A., Arai T., Lamenzo J.O., Dean III E.F., Patterson N., Clemons P.A., and Schreiber S.L. J. Am. Chem. Soc. 126 (2004) 14740-14745
12. Lee H.B., Zaccaro M.C., Pattarawarapan M., Roy S., Saragovi H.U., and Burgess K. J. Org. Chem. 69 (2004) 701-713
13. Pedersen B.S., Scheybe S., Nilsson N.H., and Lawesson S.-O. Bull. Soc. Chim. Belg. 87 (1978) 223-228
14. Berg U., Grimaud M., and Sandström J. Nouv. J. Chim. 3 (1979) 175-181
15. Rosenbaum C., Baumhof P., Mazitschek R., Müller O., Giannis A., and Waldmann H. Angew. Chem., Int. Ed. 43 (2004) 224-228
16. Guidi A., Theurillat-Moritz V., Vogel P., and Pinkerton A.A. Tetrahedron: Asymmetry 7 (1996) 3153-3162
17. Theurillat-Moritz V., and Vogel P. Tetrahedron: Asymmetry 7 (1996) 3163-3168
18. Albert J.S., Ohnmacht C., Bernstein P.R., Rumsey W.L., Aharony D., Alelyunas Y., Russel D.J., Potts W., Sherwood S.A., Shen L., Dedinas R.F., Palmer W.E., and Russell K. J. Med. Chem. 47 (2004) 519-529
19. Altamura M., Balacco G., Giolitti A., Guidi A., Patacchini R., Renzetti A.R., Triolo A., and Maggi C.A. Lett. Drug Des. Discov. 1 (2004) 285-288
20. Balacco G. J. Chem. Inf. Comput. Sci. 34 (1994) 1235-1241
21. Meini S., Catalani C., Bellucci F., Cucchi P., Giuliani S., Zappitelli S., Rotondaro L., Pasqui F., Guidi A., Altamura M., Giolitti A., and Maggi C.A. Eur. J. Pharmacol. 516 (2005) 104-111