Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice

Cancer Research

Volumn 66, Issue 10, 2006, Pages 5029-5038

  Fenske, Timothy S ^a   McMahon, Christine ^c   Edwin, Deepa ^a   Jarvis, Joseph C ^a   Cheverud, James M ^a   Minn, Matthew ^a   Mathews, Vikram ^a   Bogue, Molly A ^b   Province, Michael A ^a   McLeod, Howard L ^a   Graubert, Timothy A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TUMOR; CANCER INCIDENCE; CANCER SUSCEPTIBILITY; CHROMOSOME 15; CHROMOSOME 3; CHROMOSOME 6; CHROMOSOME 9; CONTROLLED STUDY; GENE IDENTIFICATION; GENE MAPPING; HEMATOPOIETIC SYSTEM TUMOR; HISTOLOGY; LUNG ADENOMA; LUNG CARCINOMA; LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SOFT TISSUE CANCER; T CELL LYMPHOMA;

ALKYLATING AGENTS; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; COCARCINOGENESIS; ETHYLNITROSOUREA; GENETIC PREDISPOSITION TO DISEASE; HEMATOLOGIC NEOPLASMS; LUNG NEOPLASMS; MICE; MICE, INBRED STRAINS; MUTAGENS; NEOPLASMS, EXPERIMENTAL; QUANTITATIVE TRAIT LOCI;

EID: 33744913818     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3404     Document Type: Article

References (50)

1. Curtis RE, Boice JD, Jr., Stovall M, et al. Risk of leukemia after chemotherapy and radiation treatment for breast cancer. N Engl J Med 1992;326:1745-51.
2. Kaldor JM, Day NE, Clarke EA, et al. Leukemia following Hodgkin's disease. N Engl J Med 1990;322:7-13.
3. Travis LB, Curtis RE, Boice JD, Jr., Hankey BF, Fraumeni JF, Jr. Second cancers following non-Hodgkin's lymphoma. Cancer 1991;67:2002-9.
4. Travis LB, Gospodarowicz M, Curtis RE, et al. Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease. J Natl Cancer Inst 2002;94:182-92.
5. Pedersen-Bjergaard J, Rowley JD. The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood 1994;83:2780-6.
6. Allan JM, Smith AG, Wheatley K, et al. Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy. Blood 2004;104:3872-7.
7. Felix CA, Hosler MR, Provisor D, et al. The p53 gene in pediatric therapy-related leukemia and myelodysplasia. Blood 1996;87:4376-81.
8. Maris JM, Wiersma SR, Mahgoub N, et al. Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1. Cancer 1997;79:1438-46.
9. Mahgoub N, Taylor BR, Le Beau MM, et al. Myeloid malignancies induced by alkylating agents in Nf1 mice. Blood 1999;93:3617-23.
10. Felix CA, Walker AH, Lange BJ, et al. Association of CYP3A4 genotype with treatment-related leukemia. Proc Natl Acad Sci U S A 1998;95:13176-81.
11. Roddam PL, Rollinson S, Kane E, et al. Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. Pharmacogenetics 2000;10:605-15.
12. Naoe T, Takeyama K, Yokozawa T, et al. Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/myelodysplastic syndrome and de novo acute myeloid leukemia. Clin Cancer Res 2000;6:4091-5.
13. Blanco JG, Edick MJ, Hancock ML, et al. Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies. Pharmacogenetics 2002;12:605-11.
14. Smith MT, Wang Y, Kane E, et al. Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults. Blood 2001;97:1422-6.
15. Ye Z, Song H. Glutathione 5-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis. Eur J Cancer 2005;41:980-9.
16. Malkinson AM. The genetic basis of susceptibility to lung tumors in mice. Toxicology 1989;54:241-71.
17. Hitotsumachi S, Carpenter DA, Russell WL. Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc Natl Acad Sci U S A 1985;82:6619-21.
18. Weber JS, Salinger A, Justice MJ. Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strains. Genesis 2000;26:230-3.
19. Justice MJ, Carpenter DA, Favor J, et al. Effects of ENU dosage on mouse strains. Mamm Genome 2000;11:484-8.
20. Sokal RR, Rohlf FJ. Biometry: the principles and practice of statistics in biological research. 3rd ed. New York: W.H. Freeman: 1995.
21. Falconer DS, Mackay T. Problems on quantitative genetics. London; New York: Longman; 1997.
22. Grupe A, Germer S, Usuka J, et al. In silico mapping of complex disease-related traits in mice. Science 2001;292:1915-8.
23. Cohen J. Applied multiple regression/correlation analysis for the behavioral sciences. 3rd ed. Mahwah, N.J.: L. Erlbaum Associates; 2003.
24. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003;100:9440-5.
25. Cheverud JM, Ehrich TH, Hrbek T, Kenney JP, Pletscher LS, Semenkovich CF. Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes 2004;53:3328-36.
26. Peters LL, Barker JE. Hematology, clotting, and thrombosis. Mouse Phenome Database web site. 2006;MPD:62.
27. Ober C, Abney M, McPeek MS. The genetic dissection of complex traits in a founder population. Am J Hum Genet 2001;69:1068-79.
28. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85.
29. Chen J, Harrison DE. Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood. Blood 2002;99:561-6.
30. Henckaerts E, Geiger H, Langer JC, Rebollo P, Van Zant G, Snoeck HW. Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokines. Blood 2002;99:3947-54.
31. Shimkin MB, Stoner GD. Lung tumors in mice: application to carcinogenesis bioassay. Adv Cancer Res 1975;21:1-58.
32. Tripodis N, Hart AA, Fijneman RJ, Demant P. Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst 2001;93:1484-91.
33. Gariboldi M, Manenti G, Canzian F, et al. A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6. Nat Genet 1993;3:132-6.
34. Wang M, Devereux TR, Vikis HG, et al. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res 2004;64:1924-31.
35. Zhang Z, Futamura M, Vikis HG, et al. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proc Natl Acad Sci USA 2003;100:12642-7.
36. Malkinson AM. Molecular comparison of human and mouse pulmonary adenocarcinomas. Exp Lung Res 1998;24:541-55.
37. Jackson EL, Willis N, Mercer K, et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 2001;15:3243-8.
38. Darvasi A. In silico mapping of mouse quantitative trait loci. Science 2001;294:2423.
39. Bailey-Wilson JE, Amos CI, Pinney SM, et al. A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet 2004;75:460-74.
40. Naf D, Krupke DM, Sundberg JP, Eppig JT, Bult CJ. The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse. Cancer Res 2002;62:1235-40.
41. Mucenski ML, Bedigian HG, Shull MM, Copeland NG, Jenkins NA. Comparative molecular genetic analysis of lymphomas from six inbred mouse strains. J Virol 1988; 62:839-46.
42. van Leeuwen FE, Klokman WJ, Hagenbeek A, et al. Second cancer risk following Hodgkin's disease: a 20-year follow-up study. J Clin Oncol 1994;12:312-25.
43. Furth J. The creation of the AKR strain, whose DNA contains the genome of a leukemia virus. Cancer Research Institute, NIAID: Academic Press; 1978.
44. Mucenski ML, Taylor BA, Ihle JN, et al. Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors. Mol Cell Biol 1988;8:301-8.
45. Bedigian HG, Johnson DA, Jenkins NA, Copeland NG, Evans R. Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice. J Virol 1984;51:586-94.
46. Li J, Shen H, Himmel KL, et al. Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet 1999;23:348-53.
47. Castilla LH, Garrett L, Adya N, et al. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nat Genet 1999;23:144-6.
48. Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 2002;1:63-74.
49. Kaldor JM, Day NE, Kittelmann B, et al. Bladder tumours following chemotherapy and radiotherapy for ovarian cancer: a case-control study. Int J Cancer 1995;63:1-6.
50. Hawkins MM, Wilson LM, Burton HS, et al. Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 1996;88:270-8.