A novel post-transcriptional splicing form of the acute T cell leukemia proto-oncogene Lmo2

Science in China, Series C: Life Sciences

Volumn 44, Issue 6, 2001, Pages 561-569

  Zhu, Tianhui ^a   Gang, Qin ^a   Royer Pokora, Brigitle ^b  

^a NANKAI UNIVERSITY   (China)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Lmo2; Promoter activity; RT PCR; Spiking form; Transcript

Indexed keywords

EID: 33744848171     PISSN: 10069305     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02879349     Document Type: Article

References (26)

1. Feuerstein, R., Wang, X., Song, D. et al., The LIM/double zinc-ringer motif: A novel protein dimerization domain, Proc. Natl. Acad. Sci. USA, 1994, 91: 10655-10659.
2. Schmeichel, K. L., Beckerle, M. C., The LIM domain is a modular protein-binding inrerface, Cell, 1994, 79: 211-219.
3. Boehm, T., Foroni, L., Kaneko, Y. et al., The rhombotin family of cystein-rich LIM-domain oncogenes: distinct memoers are involved in T-cell translocatioas to human chromosome 11p15 and 11p13, Pro. Natl. Acad. Sci. USA, 1991, 88: 4367-4371.
4. Royer-Pokora, B., Uschi, L., Ludwig, W. D. et al., TTG-2, a new gene encoding a cysteine-rich protein with LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11), Oncogene, 1991, 6: 1887-1893.
5. Warren, A. J., Colledge, W. H., Carlton, M. B. et al., The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development, Cell, 1994, 78: 45-57.
6. Visvader, J. E., Mao, X. H., Fujuwara, Y. et al., The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation, Pro. Natl. Acad. Sci. USA, 1997, 94: 13707-13712.
7. Yamada, Y, Warren, A. J., Dobson, C. et al., The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis, Pro. Natl. Acad. Sci. USA, 1998, 95: 3890-3895.
8. Yamada, Y., Pannell, R., Alan, F. et al., The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice, Proc. Nat;. Acad. Sci. USA, 2000, 97: 320-324.
9. Royer-Pokora, B., Rogers, M., Zhu, T. H. et al., The TTG-2/RBTN-2 T cell oncogene encodes two alternative transcripts from two promoters: the distal promoter is removed by most 11p13 translocations in acute T cell leukaemia's (T-ALL), Oncogene, 1995, 10: 1353-1360.
10. Carninci, P., Nishiyama, Y., Westover, A. et al., Thermostabilization and thermo-activation of thermolabile enzymes by trehaiose and its application for the synthesis of full length cDNA, Proc. Natl. Acad. Sci. USA, 1998, 95(1): 520-552.
11. Look, A. T., Oncogenic transcription factors in the human acute leukemias, Science, 1997, 278: 1059-1064.
12. Fitzgerald, T. J., Neale, G. A. M., Raimondi, S. C. et al., Rhom-2 expression does not always correlate with abnormalities on chromosome 11 at band p13 in T-cell acute lymphoblastic leukemia. Blood, 1992, 80: 3189-3197.
13. Robb, L., Lyons, I., Li, R. et al., Absence of yolk sac hematopoiesis from mice with a targeted disruption of the sci gene, Proc. Natl. Acad. Sci. USA. 1995, 92: 7075-7079.
14. Shivdasani, R. A., Mayer, E. L., Orkin, S. H., Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL, Nature, 1995, 373: 432-434.
15. Aplan, P. D., Jones, C. A., Chervinsky, D. S. et al., An sc1 gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice, EMBO J, 1997, 16: 2408-2419.
16. Valge-Archer, V. E., Osada, H., Warren, A. J. et al., The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells, Pro. Natl. Acad. Sci. USA, 1994, 91: 8617-8621.
17. Wadman, I., Li, J., Bash, R. et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia, EMBO J., 1994, 13:4831-4839.
18. Wadman, I. A., Osada, H., Grutz, G. G. et al., The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA1 and Ldb1/KLI proteins, EMBO J., 1997, 16: 3145-3157.
19. Visvader, J. E., Mao, X. H., Fujiwara, Y. et al., The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation, Proc. Natl. Acad. Sci. USA, 1997, 94: 13707-13712.
20. Zhou, Y., Du, G. W., Wang, J. H. et al., The separation and cloning of human LDB1 cDNA, Chinese Science Bulletin, 1999, 44(8): 755-760.
21. Grutz, G. G., Bucher, K., Lavenir, I. et al., The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells, EMBO J., 1998, 17: 4594-4605.
22. Rabbitts, T. H., LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes, Gene & Dev., 1998, 12: 2551-2657.
23. Rabbins, T. H, Bucher, K., Chung, G. et al., The effect of chromosomal transiocations in acute leukemias: The LMO2 paradigm in transcription and development, Cancer Res., 1999, 39: 1794-1798.
24. Foroni, L., Boehm, T., White, L. et al., The rhornbotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles on mouse development, J. Mol. Biol., 1992, 226: 747-761.
25. Bernard, O., Lecointe, N., Jonveaux, P. et al., Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute ieukernias disrupt the 5′ part of the TALI gene, Oncogene, 1991, 6: 1477-1488.
26. Cheng, J. T., Hsu, H. L., Hwang, L. Y. et al., Products of the TAL1 oncogene : basic helix-ioop-helix proteins phosphorylated at serine residues, Oncogene, 1993, 8: 677-683.