The expression of hypoxia inducible factor-1α and apoptosis in herniated discs

Spine

Volumn 31, Issue 12, 2006, Pages 1309-1313

  Ha, Kee Yong ^a   Koh, In Jun ^a   Kirpalani, Papni Arjandas ^a   Kim, Young Yul ^a   Cho, Yun Kyoung ^a   Khang, Gil Son ^a   Han, Chang Whan ^a,b  

^a The Catholic University of Korea   (South Korea)

^b Daejeon St Mary's Hospital   (South Korea)

Author keywords

Apoptosis; Herniation; Hypoxia inducible factor 1

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ADULT; AGING; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK HERNIA; MALE; NICK END LABELING; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; APOPTOSIS; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; MIDDLE AGED;

EID: 33744805779     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000219493.76081.d6     Document Type: Article

References (26)

1. Benoist M. The natural history of lumbar disc herniation and radiculopathy. Joint Bone Spine 2002;69:155-60.
2. Haro H, Kato T, Komori H, et al. Vascular endothelial growth factor (VEGF)-induced angiogenesis in herniated disc resorption. J Orthop Res 2002;20:409-15.
3. Ito T, Takano Y, Yuasa N. Types of lumbar herniated disc and clinical course. Spine 2001;15;26:648-51.
4. Komori H, Shinomiya K, Nakai O, et al. The natural history of herniated nucleus pulposus with radiculopathy. Spine 1996;15;21:225-9.
5. Saal JA. Natural history and nonoperative treatment of lumbar disc herniation. Spine 1996;21:2-9s.
6. Yamashita K, Hiroshima K, Kurata A. Gadolinium-DTPA-Enhanced magnetic resonance imaging of a sequestered lumbar intervertebral disc and its correlation with pathologic findings. Spine 1994;19:479-82.
7. Yukawa Y, Kato F, Matsubara Y, et al. Serial magnetic resonance imaging follow-up study of lumbar disc herniation conservatively treated for average 30 months: Relation between reduction of herniation and degeneration of disc. J Spinal Disord 1996;9:251-6.
8. Doita M, Kanatani T, Ozaki T, et al. Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption. Spine 2001;26:1522-7.
9. Grang L, Gaudin P, Trocme C, et al. Intervertebral disk degeneration and herniation: The role of metalloproteinases and cytokines. Joint Bone Spine 2001;68:547-53.
10. Semenza GL. Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease. Pediatr Res 2001;49:614-7.
11. Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 2002;16:1151-62.
12. Coimbra IB, Jimenez SA, Hawkins DF, et al. Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cartilage 2004;12:336-45.
13. Rajpurohit R, Risbud MV, Ducheyne P, et al. Phenotypic characteristics of the nucleus pulposus: Expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res 2002;308:401-7.
14. Bibby SR, Jones DA, Lee RB, et al. The pathophysiology of the intervertebral disc. Joint Bone Spine 2001;68:537-42.
15. Gruber HE, Hanley EN Jr. Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine 1998;23:751-7.
16. Gruber HE, Norton HJ, Hanley EN Jr. Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine 2000;25:2153-7.
17. Ozaki S, Muro T, Ito S, et al. Neovascularization of the outermost area of herniated lumbar intervertebral discs. J Orthop Sci 1999;4:286-92.
18. Virri J, Gronblad M, Savikko J, et al. Prevalence, morphology, and topography of blood vessels in herniated disc tissue. A comparative immunocytochemical study. Spine 1996;21:1856-63.
19. Moore RJ, Vernon-Roberts B, Fraser RD, et al. The origin and fate of herniated lumbar intervertebral disc tissue. Spine 1996;21:2149-55.
20. Moritz W, Meier F, Stroka DM, et al. Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression. FASEB J 2002;16:745-7.
21. Kim KW, Lim TH, Kim JG, et al. The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs. Spine 2003;28:982-90.
22. Yasuma T, Arai K, Yamauchi Y. The histology of lumbar intervertebral disc herniation. The significance of small blood vessels in the extruded tissue. Spine 1993;18:1761-5.
23. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine 1995;20:1307-14.
24. Lee MJ, Kim JY, Suk K, et al. Identification of the hypoxia-inducible factor 1-alpha responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol 2004;24:3918-27.
25. Halterman MW, Federoff HJ. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol 1999;159:65-72.
26. Ju Y, He M, Mao B. Sequential changes of hypoxia-inducible factor 1-alpha in experimental spinal cord injury and its significance. Chin J Traumatol 2002;5:103-6.