The tramadol metabolite, O-Desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes

Pharmacology

Volumn 77, Issue 2, 2006, Pages 93-99

  Horishita, Takafumi ^a   Minami, Kouichiro ^a   Uezono, Yasuhito ^b   Shiraishi, Munehiro ^a   Ogata, Junichi ^a   Okamoto, Takashi ^c   Shigematsu, Akio ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^c Fukuoka Institute of Occupational Health   (Japan)

Author keywords

5 Hydroxytryptamine; O Desmethyl tramadol; Tramadol; Xenopus oocytes

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ANALGESIC AGENT; BRAIN RECEPTOR; CALCIUM ACTIVATED CHLORIDE CHANNEL; CHLORIDE CHANNEL; DRUG METABOLITE; G PROTEIN COUPLED RECEPTOR; O NORTRAMADOL; PROTEIN KINASE C INHIBITOR; SEROTONIN; SEROTONIN 2C RECEPTOR; TRAMADOL; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CHLORIDE CURRENT; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEEDING; FEMALE; GENE EXPRESSION SYSTEM; LOCOMOTION; NOCICEPTION; NONHUMAN; OOCYTE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RECEPTOR BLOCKING; SEROTONINERGIC SYSTEM; XENOPUS;

ANIMALS; FEMALE; INDOLES; MALEIMIDES; OOCYTES; PROTEIN KINASE C; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN; TRAMADOL; XENOPUS LAEVIS;

EID: 33744789164     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093179     Document Type: Article

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