Serum concentrations of tramadol enantiomers during patient-controlled analgesia

British Journal of Clinical Pharmacology

Volumn 48, Issue 2, 1999, Pages 254-257

  Grond, Stefan ^a   Meuser, Thomas ^a   Uragg, Heinz ^b   Stahlberg, Hans J ^b   Lehmann, Klaus A ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b GRÜNENTHAL GMBH   (Germany)

Author keywords

Enantiomer; Opioid; Pharmacokinetic; Postoperative pain; Tramadol

Indexed keywords

TRAMADOL;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG POTENCY; ENANTIOMER; FEMALE; GYNECOLOGIC SURGERY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RACEMIC MIXTURE; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS, OPIOID; BIOTRANSFORMATION; DOUBLE-BLIND METHOD; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYSTERECTOMY; LAPAROTOMY; MIDDLE AGED; PAIN, POSTOPERATIVE; STEREOISOMERISM; TRAMADOL;

EID: 0032775742     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00986.x     Document Type: Article

References (13)

1. 1 Radbruch L, Grond S, Lehmann KA. A risk-benefit assessment of tramadol in the management of pain. Drug Safety 1996; 15: 8-29.
2. 2 Raffa RB, Nayak RK, Liao S, Minn FL. The mechanism(s) of action and pharmacokinetics of tramadol hydrochloride. Rev Contemp Pharmacother 1995; 6: 485-497.
3. 3 Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. Opioid and nonopioid components independently contribute to the mechanisms of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther 1992; 260: 275-285.
4. 4 Raffa RB, Friderichs E, Reimann W, et al. Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exp Ther 1993; 267: 331-340.
5. 5 Lintz W, Erlacin S, Frankus E, Uragg H. Metabolismus von Tramadol bei Mensch und Tier. Arzneim Forsch/Drug Res 1981; 31: 1932-1943.
6. 6 Lai J, Shou-wu M, Porreca F, Raffa RB. Tramadol, MI metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells. Eur J Pharmacol 1996; 316: 369-372.
7. 7 Grond S, Meuser T, Zech D, Hennig U, Lehmann KA. Analgesic efficacy and safety of tramadol enantiomers in comparison with the racemate: a randomised, double-blind study with gynaecological patients using intravenous patient controlled analgesia. Pain 1995; 62: 313-320.
8. 8 Becker R, Lintz W. GC/NPD method for the stereoselective determination of the enantiomers of tramadol and its metabolite M 1 in human serum. Report FO-PK 323/I, Grünenthal GmbH, D-52078 Aachen, 1993.
9. 9 Lintz W, Uragg H. Quantitative determination of tramadol in human serum by gas chromatography-mass spectrometry. J Chromatogr 1985; 341: 65-79.
10. 10 Ossig J, Terlinden R, Lintz W. GC/NPD method for the stereoselective determination of the enantiomers of tramadol and its metabolite M 1 in human serum after derivatisation. Report FO-PK 389, Grünenthal GmbH, D-52078 Aachen, 1993.
11. 11 Gourlay GK, Willis RJ, Wilson RJ. Postoperative pain control with methadone: influence of supplementary methadone doses and blood concentration-response relationships. Anesthesiol 1984; 61: 19-26.
12. 12 Hackl W, Fitzal S, Lackner F, Weindlmayr Goettel M. Fentanyl or tramadol in patient-controlled analgesia for treatment of postoperative pain. Anaesthesist 1986; 35: 665-671.
13. 13 Lehmann KA, Kratzenberg U, Schroeder-Bark B, Horrichs-Haermeyer G. Postoperative patient-controlled analgesia with tramadol: analgesic efficacy and minimum effective concentrations. Clin J Pain 1990; 6: 212-220.