Tramadol produces outward currents by activating μ-opioid receptors in adult rat substantia gelatinosa neurones

British Journal of Pharmacology

Volumn 145, Issue 5, 2005, Pages 602-607

  Koga, Akiko ^a   Fujita, Tsugumi ^a   Totoki, Tadahide ^a   Kumamoto, Eiichi ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

opioid receptor; Antinociception; Hyperpolarization; Patch clamp; Substantia gelatinosa; Tramadol

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; DRUG METABOLITE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MONO O DIMETHYLTRAMADOL; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; NORADRENALIN; POTASSIUM ION; TRAMADOL; UNCLASSIFIED DRUG; YOHIMBINE;

ADOLESCENT; ANALGESIA; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; HYPERPOLARIZATION; MALE; MEDIAN EFFECTIVE CONCENTRATION; MEMBRANE CURRENT; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD; SUBSTANTIA GELATINOSA; WHOLE CELL;

ANALGESICS, OPIOID; ANIMALS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; MALE; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, OPIOID, MU; SPINAL CORD; SUBSTANTIA GELATINOSA; SYMPATHOLYTICS; SYMPATHOMIMETICS; TRAMADOL;

EID: 22744459156     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706225     Document Type: Article

References (21)

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