Thymosin β4 and AcSDKP inhibit the proliferation of HL-60 cells and induce their differentiation and apoptosis

Cell Biology International

Volumn 30, Issue 6, 2006, Pages 514-520

  Huang, Wei Qi ^a   Wang, Bao He ^b   Wang, Qi Ru ^a  

^a Central South University   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

Author keywords

AcSDKP; Apoptosis; Differentiation; HL 60; Thymosin 4

Indexed keywords

SERASPENIDE; THYMOSIN BETA4; CALCIUM; DNA FRAGMENT; OLIGOPEPTIDE; THYMOSIN; THYMOSIN BETA(4);

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; EVALUATION; EXTRACELLULAR CALCIUM; GENE EXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOLECULAR WEIGHT; ANIMAL; CATTLE; CELL STRAIN HL 60; DNA MICROARRAY; METABOLISM; MYELOID LEUKEMIA; PATHOLOGY; PHYSIOLOGY; UPREGULATION;

ANIMALS; APOPTOSIS; CALCIUM; CATTLE; DNA FRAGMENTATION; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGOPEPTIDES; THYMOSIN; UP-REGULATION;

EID: 33744747605     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2006.01.009     Document Type: Article

References (37)

1. Baxevanis C.N., Reclos G.J., Perez S., Kokkinopoulos D., and Papamichail M. Immunoregulatory effects of fraction 5 thymus peptides. 1. Thymosin α1 enhances while thymosin β4 suppress the human autologous and allogeneic lymphocyte reaction. Immunopharmacology 13 (1987) 133-141
2. Boutonnat J., Faussat A.M., Marie J.P., Bignon J., Wdzieczak-Bakala J., Barbier M., et al. Usefulness of PKH fluorescent labeling to study leukemic cell proliferation with various cytostatic drugs or acetyl tetrapeptide-AcSDKP. BMC Cancer 5 1 (2005) 120
3. Cassimeris L., Safer D., Nachmias V.T., and Zigmond S.H. Thymosin β4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes. J cell Biol 119 (1992) 1261-1270
4. Catino J.J., and Miceli L.A. Microtiter assay useful for screening of cell-differentiation agents. J Natl Cancer Inst 80 (1988) 962-966
5. Cha H.J., Jeong M.J., and Kleinman H.K. Role of thymosin 4 in tumor metastasis and angiogenesis. J Natl Cancer Inst 95 (2003) 1674-1680
6. Charrier S., Michaud A., Badaoui S., Giroux S., Ezan E., Sainteny F., et al. Inhibition of angiotensin 1-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells. Blood 104 (2004) 978-985
7. Cheng L.M., and Wang Q.R. Hematopoietic inhibitors elaborated by bone marrow endothelial cells. J Exp Hematol 10 (2002) 485-491
8. Cheng L.M., Yan Y., and Wang Q.R. Expression of hematopoietic inhibitory factors in mouse fibroblasts, macrophages and endothelial cells. Cell Biol Int 27 (2003) 739-745
9. Chou K.C., Tomasselli A.G., and Heinrikson R.L. Prediction of the tertiary structure of a caspcase-9/inhibitor complex. FEBS Lett 470 (2000) 249-256
10. Defard M., Lemoine F.M., Bonnet M.L., Baillou C., Isnard F., Najman A., et al. Comparison of the effects of AcSDKP, thymosin beta4, macrophage inflammatory protein 1alpha and transforming growth factor beta on human leukemic cells. Leuk Lymphoma 27 (1997) 487-494
11. Fernandes-Alnemri T., Armstrong R.C., Krebs J., Srinivasula S.M., Wang L., Bullrich F., et al. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A 93 15 (1996) 7464-7469
12. Goldstein A.L., Hannappel E., and Kleinman H.K. Thymosin beta(4): actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med 11 9 (2005) 421-429
13. Goodall G.J., Morgan J.I., and Horecker B.L. Thymosin β4 in cultured mammalian cell lines. Arch Biochem Biophys 221 (1983) 598-601
14. Gregory C.D., Dive C., Henderson S., Smith C.A., Williams G.T., Gordon J., et al. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 349 (1991) 612-614
15. Gregory M.A., Xiao Q., Cornwall G.A., Lutterbach B., and Hann S.R. B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation. Oncogene 19 (2000) 4886-4895
16. Hannappel E., Xu G., Morgan J., Hempstead J., and Horecker B.L. Thymosin β4: an ubiquitous peptide in rat and mouse tissues. Proc Natl Acad U S A 79 (1982) 2172-2175
17. Hannappel E., and Leibold W. Biosynthesis rates and content of thymosin β4 in cell lines. Arch Biochem Biophys 240 (1985) 236-241
18. Herrmann M., Lorenz H.M., Voll R., Grunke M., Woith W., and Kalden J.R. A rapid and simple method for the isolation of apoptotic DNA fragment. J Nucleic Acid Res 22 (1994) 5506-5507
19. 4 and AcSDKP. Exp Hematol 29 (2001) 12-18
20. Huff T., Muller C.S., Otto A.M., and Netzker R. Thymosins, small acidic peptides with multiple function. Int J Biochem Cell Biol 33 (2001) 205-220
21. Jackson J.D., Yan Y., Ewel C., and Talmadge J.E. Activity of Acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) on hematopoietic progenitor cells in short-term and long-term murine bone marrow cultures. Exp Hematol 24 (1996) 475-481
22. Kokkinopoulos D., Perez S., and Papamichail M. Thymosin β4 induced phenotypic changes in Molt-4 leukemic cell lines. Blut 50 (1985) 341-348
23. Liu J.M., Lawrence F., Kovacevic M., Bignon J., Papadimitriou E., Lallemand J.Y., et al. The tetrapeptide AcSDKP, an inhibitor of hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo. Blood 101 (2003) 3014-3020
24. Low T.L., Hu S.K., and Goldstein A.L. Complete amino acid sequence of bovine thymosin β4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. Proc Natl Acad U S A 78 (1981) 1162-1166
25. McConkey D.J., and Orrenius S. Signal transduction pathways to apoptosis. Trends Cell Biol 4 (1994) 370-375
26. Mitsuhashi M., Mitsuhashi T., and Payan D.G. Multiple signaling pathways of histamine H2 receptors. J Biol Chem 264 (1989) 18356-18362
27. Ng P.W., Porter A.G., and Janicke R.U. Molecular cloning and characterization of two novel proapoptotic isoforms of caspase-10. J Biol Chem 274 (1999) 10301-10308
28. Philp D., Goldstein A.L., and Kleinman H.K. Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev 125 (2004) 113-115
29. Ruefli A.A., Smyth M.J., and Johnstone R.W. HMBA induces activation of a caspase independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood 95 (2000) 2378-2385
30. Schwartzman R.A., and Cidlowski J.A. Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocr Rev 14 (1993) 133-151
31. Spangelo B.L., Pompilius M., Farrimond D.D., Stevens N., Nieva R., Shroff S., et al. Presence of a peptide component of thymosin fraction-5 manifesting discrete cytostatic properties in HL-60 human promyelocytic leukemia cells. Int Immunopharmacol 5 (2005) 1317-1329
32. Srinivasula S.M., Ahmad M., Fernandes-Alnemri T., Litwack G., and Alnemri E.S. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A 93 (1996) 14486-14491
33. 2+ level in nonsteroidal anti-inflammatory drug induced apoptosis. J Biol Chem 280 35 (2005) 31059-31067
34. Wang W.S., Chen P.M., Hsiao H.L., Wang H.S., Liang W.Y., and Su Y. Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 23 39 (2004) 6666-6671
35. Watanabe T., Brown G.S., Kelsey L.S., Yan Y., Jackson J.D., Ewel C., et al. In vivo protective effects of tetrapeptide AcSDKP, with or without granulocyte colony-stimulating factor, on murine progenitor cells after sublethal irradiation. Exp Hematol 24 (1996) 713-721
36. waf1/cip1. J Cell Biochem 70 (1998) 70-83
37. 2+ in myocardiac H9c2 cells. J Biol Chem 279 49 (2004) 51182-51192