Ghrelin test for the assessment of GH status in successfully treated patients with acromegaly

European Journal of Endocrinology

Volumn 154, Issue 5, 2006, Pages 659-666

  Pekic, S ^a   Doknic, M ^a   Miljik, D ^a   Joksimovic, M ^b   Glodic, J ^c   Djurovic, M ^a   Dieguez, C ^d   Casanueva, F ^e   Popovic, V ^a  

^a ENT Head and Neck Surgery Clinic   (Yugoslavia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

^c Laboratory Consilium   (Yugoslavia)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^e HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GHRELIN; GLUCOSE; GROWTH HORMONE; LEPTIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; TRIACYLGLYCEROL;

ACROMEGALY; ADULT; AGED; ARTICLE; BODY MASS; CANCER RADIOTHERAPY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; ENDOCRINE SURGERY; FEMALE; FOLLOW UP; GROWTH HORMONE RELEASE; HORMONE DETERMINATION; HUMAN; INTERMETHOD COMPARISON; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROVOCATION TEST; SEX DIFFERENCE; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

ACROMEGALY; ADULT; AGE FACTORS; AGED; DIAGNOSTIC TECHNIQUES, ENDOCRINE; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; LIPIDS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBESITY; PEPTIDE HORMONES; PITUITARY GLAND; POSTOPERATIVE COMPLICATIONS;

EID: 33744531421     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.02148     Document Type: Article

References (35)

1. Rajasoorya C, Holdaway J, Wrightson P, Scott D & Ibbertson H. Determinants of clinical outcome and survival in acromegaly. Clinical Endocrinology 1994 41 95-102.
2. Bates A, Van't Hoff W, Jones J & Clayton R. An audit of outcome of treatment in acromegaly. Quarterly Journal of Medicine 1993 86 293-299.
3. Lombardi G, Colao A, Ferone D, Marzullo P, Landi ML, Longobardi S, Iervolino, E, Cuocolo A, Fazio S, Merola B & Sacca L. Cardiovascular aspects in acromegaly: effects of treatment. Metabolism 1996 45 57-60.
4. Melmed S. Acromegaly and cancer: not a problem. Journal of Clinieal Endocrinology and Metabolism 2001 86 2929-2934.
5. Jenkins P & Besser M. Acromegaly and cancer: a problem. Journal of Clinical Endocrinology and Metabolism 2001 86 2935-2941.
6. Orme S, McNally R, Cartwright R & Belchetz P. Mortality and cancer incidence in acromegaly: a retrospective cohort study. Journal of Clinical Endocrinology and Metabolism 1998 83 3411-3418.
7. Holdaway I, Rajasoorya R & Gamble G. Factors influencing mortality in acromegaly, Journal of Clinical Endocrinology and Metabolism 2004 89 667-674.
8. Dimaraki E, Jaffe C, De Mott-Friberg R, Chandler W & Barkan A. Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up. Journal of Clinical Endocrinology and Metabolism 2002 87 3537-3542.
9. Giustina A, Barkan A, Casanueva F, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Von Werder K & Melmed S. Criteria for cure of acromegaly: a consensus statement. Journal of Clinical Endocrinology and Metabolism 2000 85 526-529.
10. Melmed S, Casanueva F, Cavagnini F, Chanson P, Frohman L, Grossman A, Ho K, Kleinberg D, Lamberts S, Laws E, Lombardi G, Vance ML, Werder KV, Wass J, Giustina A & Acromegaly Treatment Consensus Workshop Participants. Guidelines for acromegaly management. Journal of Clinical Endocrinology and Metabolism 2002 87 4054-4058.
11. Consensus Statement. Biochemical assessment and long-term monitoring in patients with acromegaly: statement from a joint consensus conference of the Growth Hormone Research Society and the Pituitary Society. Journal of Clinical Endocrinology and Metabolism 2004 89 3099-3102.
12. Freda P. Current concepts in the biochemical assessment of the patient with acromegaly. Growth Hormone and IGF Research 2003 13 171-184.
13. Murray R & Shalet S. Adult growth hormone replacement: lessons learned and future directions. Journal of Clinical Endocrinology and Metabolism 2002 87 4427-4428.
14. Growth Hormone Research. Society. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. Journal of Clinical Endocrinology and Metabolism 1998 83 379-381.
15. Ghigo E, Aimaretti G, Arvat E & Cammani E Growth hormone-releasing hormone combined with arginine or growth hormone secretagogues for the diagnosis of growth hormone deficiency in adults. Endocrine 2001 15 29-38.
16. Popovic V, Leal A, Micic D, Koppeschaar H, Torres E, Paramo C, Obradovic S, Dieguez C & Casanueva FF. GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults. Lancet 2000 356 1137-1142.
17. Muccioli G, Ghe C, Ghigo MC, Papotti M, Arvat E, Boghen MF, Nilsson MH, Deghenghi R, Ong H & Ghigo E. Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland. Journal of Endocrinology 1998 157 99-106.
18. Korbonits M, Jacobs RA, Aylwin SJ, Burrin JM, Dahia PL, Monson JP, Honegger J, Fahlbush R, Trainer PJ, Chew SL, Besser GM & Grossman AB. Expression of the growth hormone secretagogue receptor in pituitary adenornas and other neuroendocrine tumors. Journal of Clinical Endocrinology and Metabolism 1998 83 3624-3630.
19. Popovic V, Damjanovic S, Micic D, Petakov M, Dieguez C & Casanueva E. Growth hormone (GH) secretion in active acromegaly after the combined administration of GH- releasing hormone and GH-releasing peptide-6. Journal of Clinical Endocrinology and Metabolism 1994 79 456-460.
20. Popovic V, Miljic D, Micic D, Damjanovic S, Arvat E, Ghigo E, Dieguez C & Casanueva FF. Ghrelin main action on the regulation of growth hormone release is exerted at hypothalamic level. Journal of Clinical Endocrinology and Metabolism 2003 88 3450-3453.
21. Arosio M, Ronchi C, Gebbia C, Pizzinelli S, Conte D, Cappiello V, Epaminonda P, Cesana BM, Beck-Peccoz P & Peracchi M. Ghrefin administration affects circulating pituitary and gastro-enteropancreatic hormone in acromegaly. European Journal of Endocrinology 2004 150 27-32.
22. Aimaretti G, Baffoni C, Broglio F, Janssen J, Corneli G, Deghenghi R, van der Lely A, Ghigo E & Arvat E. Endocrine responses to ghrelin in adult patients with isolated childhood-onset growth hormone deficiency. Clinical Endocrinology 2002 56 765-771.
23. Puder J, Nilavar S, Post K & Freda P. Relationship between disease-related morbidity and biochemical markers of activity in patients with acromegaly. Journal of Clinical Endocrinology and Metabolism 2005 90 1972-1978.
24. Murray R, Peacey S, Rahim A, Toogood A, Thorner M & Shalet S. The diagnosis of growth hormone deficiency (GHD) in successfully treated acromegalic patients. Clinical Endocrinology 2001 54 37-44.
25. Dattani M & Preece M. Growth hormone deficiency and related disorders: insights into causation, diagnosis and treatment. Lancet 2004 363 1977-1987.
26. Toogood AA, Beardwell CG & Shalet SM. The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism. Clinical Endocrinology 1994 41 511-516.
27. Shalet SM, Toogood A, Rahim A & Brennan BM. The diagnosis of growth hormone deficiency in children and in adults. Endocrine Reviews 1998 19 203-223.
28. Conceicao F. Fisker S, Andersen M, Kaal A, Jorgensen J, Vaisman M & Christiansen JS. Evaluation of growth hormone stimulation tests in cured acromegalic patients. Growth Hormone and IGF Research 2003 13 347-352.
29. Mukherjee A, Monson J, Jonsson P, Trainer P & Shalet S on behalf of the KIMS International Board. Seeking the optimal target range for insulin-like growth factor I during the treatment of adult growth hormone disorders. Journal of Clinical Endocrinology and Metabolism 2003 88 5865-5870.
30. Brabant G, von zur Muhlen A, Wuster C, Ranke MB, Kratzsch J, Keiss W, Ketelslegers J, Wilhelmsen L, Halten L, Saller B, Mattson A, Wilde J, Schemer R & Kann P, on behalf of the German KIMS board. Serum insulin-like growth factor-I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study. Hormone Research 2003 60 53-60.
31. Molitch M. Diagnosis of GH deficiency in adults - how good do the criteria need to be? Journal of Clinical Endocrinology and Metabolism 2002 87 473-476.
32. Drake WM, Howell SJ, Monson JP & Shalet SM. Optimizing GH therapy in adults and children. Endocrine Reviews 2001 22 425-450.
33. Damjanovic S, Neskovic A, Petakov M, Popovic V, Macut D, Vukojevic P & Joksimovic MM. Clinical indicators of biochemical remission in acromegaly: does incomplete disease control always mean therapeutic failure? Clinical Endocrinology 2005 62 410-417.
34. Damjanovic S, Petakov M, Raicevic S, Micic D, Marinkovic J, Dieguez C, Casanueva FF & Popovic V Serum leptin concentrations in patients with acromegaly before and after correction of hypersomatotropism by transphenoidal surgery. Journal of Clinical Endocrinology and Metabolism 2000 85 147-154.
35. Johansson AG, Engstrom B, Ljunghall S, Karlsson FA & Burman P. Gender differences in the effects of long term growth hormone (GH) treatment on bone in adults with GH deficiency. Journal of Clinical Endocrinology and Metabolism 1999 84 2002-2007.