Leishmania major: Low infection dose causes short-lived hyperalgesia and cytokines upregulation in mice

Experimental Parasitology

Volumn 113, Issue 3, 2006, Pages 168-173

  Karam, Marc Christophe ^a   Hamdan, Hamdan G ^a   Abi Chedid, Najib A ^a   Bodman Smith, Kikki B ^b   Eales Reynolds, Lesley Jane E ^c   Baroody, George M ^a  

^a LEBANESE AMERICAN UNIVERSITY   (Lebanon)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

Cutaneous leishmaniasis; Cytokines; Hyperalgesia; Interleukin 1 ; Interleukin 6; T helper cells

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HYPERALGESIA; LEISHMANIA MAJOR; MOUSE; MOUSE STRAIN; NONHUMAN; PAIN; PAIN THRESHOLD; PARASITOSIS; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; FEMALE; HYPERALGESIA; INTERLEUKIN-1; INTERLEUKIN-6; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; UP-REGULATION;

LEISHMANIA MAJOR;

EID: 33744530022     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2006.01.003     Document Type: Article

References (34)

1. Alexander J., and Bryson K. T helper (h)1/Th2 and Leishmania: paradox rather than paradigm. Immunology Letters 99 (2005) 17-23
2. Arendse B., Van Snick J., and Brombacher F. IL-9 is a susceptibility factor in Leishmania major infection by promoting detrimental Th2/type 2 responses. Journal of Immunology 174 (2005) 2205-2211
3. Bogdan C., and Rollinghoff M. The immune response to Leishmania: mechanisms of parasite control and evasion. International Journal of Parasitology 28 (1998) 121-134
4. Bogdan C., Gessner A., Solbuch W., et al. Invasion, control and persistence of Leishmania parasites. Current Opinion in Immunology 8 (1996) 517-525
5. Bretscher P.A., Wei G., Menon J.N., and Bielefeldt-Ohmann H. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 257 (1992) 539-542
6. Choi H.S., Ju J.S., Lee H.J., Kim B.C., Park J.S., and Ahn d.K. Effects of intracisternal injection of interleukin-6 on nociceptive jaw opening reflex and orofacial formalin test in freely moving rats. Brain Research Bulletin 59 (2003) 365-370
7. Cillari E., Dieli M., Maltese E., Milano S., Salerno A., and Liew F.Y. Enhancement of macrophage interleukin-1 production by Leishmania major infection in vitro and its inhibition by IFN-γ. Journal of Immunology 143 (1989) 2001-2005
8. Coffman R.L., Seymour B., Lebman D., Hiraki D., Christiansen J., Sthader B., Cherwinsky H., Savelkoul H., Finkelman F., Bond M., and Mosmann T.R. The role of helper T-cell products in mouse B-cell differentiation and isotype regulation. Immunological Reviews 102 (1988) 5-28
9. Cunha F.Q., Poole S., Lorenzetti B.B., and Ferreira S.H. The pivotal role of tumor necrosis factor-α in the development of inflammatory hyperalgesia. British Journal of Pharmacology 107 (1992) 660-664
10. Dinarello C.A., Ikejima T., Warner S.J., Orencole S.F., Lonnemann G., Cannon J.G., and Libby P. Interleukin-1 induces interleukin-1. I. Induction of circulating interleukin-1 in rabbits in vivo and in human mononuclear cells in vitro. Journal of Immunology 139 (1987) 1902
11. Doherty T.M., Morse III H.C., and Coffman R.L. Modulation of specific T cell responses by concurrent infection with Leishmania major and LP-BM5 murine leukemia viruses. International Immunology 7 (1995) 131-138
12. Esser C., and Radbruch A. Immunoglobulin class switching: molecular and cellular analysis. Annual Review of Immunology 8 (1990) 717-736
13. Fillipi C., Malherbe L., Julia V., and Glaichenhaus N. L'immunité contre les Leishmania. Mèdecine/sciences 17 (2001) 1120-1128
14. Flatters S.J., Fox A.J., and Dickenson A.H. Spinal interleukin-6 (IL-6) inhibits nociceptive transmission following neuropathy. Brain Research 984 (2003) 54-62
15. Kanaan A.S., Saadé E.N., Karam C.M., Jabbur J.S., Khansa H., and Jurjus R.A. Hyperalgesia and upregulation of cytokines and nerve growth factor by cutaneous leishmaniasis in mice. Pain 85 (2000) 447-482
16. Kanaan S.A., Saadé N.E., Haddad J.J., Abdelnour A.M., Atweh S.F., Jabbur S.J., and Safieh-Garabedian B. Endotoxin-induced local inflammation and hyperalgesia in rats and mice: a new model for inflammatory pain. Pain 66 (1996) 373-379
17. Kane M.M., and Mosser D.M. The role of IL-10 in promoting disease progression in leishmaniasis. Journal of Immunology 166 2 (2001) 1141-1147
18. Kubba R., EL-Hassan A.M., Al-Gindan Y., Omer A.H.S., Bushra M., and Kutty M.K. Peripheral nerve involvement in cutaneous leishmaniasis (Old World). International Journal of Dermatology 26 (1987) 527-531
19. Macatonia S.E., Hosken N.A., Littin M., Vieira P., Hsieh C.S., Culpepper J.A., Wysocka M., Trinchieri G., Murphy K.M., and O' Garra A. Dendritic cells produce IL-12 and direct the development of Th1 cells from naïve CD4+ T cells. Journal of Immunology 154 (1995) 5071-5079
20. Malcangio M., Bowery N., Flower R., and Perretti M. Effect of interleukin-1β on the release of substance P from rat isolated spinal cord. European Journal of Pharmacology 299 (1996) 113-118
21. Mosmann T.R., and Moore K.W. The role of IL-10 in cross regulation of Th1 and Th2 responses. Immunology Today 12 (1991) A49-A53
22. Newton R., Stevens D., Hart L., Lindsay M., Adcock I., and Barnes P. Superinduction of COX-2 mRNA by cycloheximide and interleukin-1β involves increased transcription and correlates with increased NF-κB and JNK activation. FEBS Letters 418 (1997) 135-138
23. Oka T., Oka K., Hosoi M., and Hori T. Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats. Brain Research 692 (1995) 123-128
24. Poole S., Cunha F.Q., and Ferreira S.H. Hyperalgesia from subcutaneous cytokines. In: Watkins L.R., and Maier S.F. (Eds). Progress in Inflammation Research. Cytokine and Pain (1999), Birkhauser Verlag AG, Basel 59-87
25. Reiner S.L., and Locksley R. The regulation of immunity to Leishmania major. Annual Review of Immunology 13 (1995) 151-177
26. + T cells. The Journal of Experimental Medicine 185 (1997) 461-469
27. Samoilova E., Horton J.L., Hilliard B., Liu T.S., and Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. Journal of Immunology 161 12 (1998) 6480-6486
28. Schindler R., Mancilla J., Endres S., Ghorbani R., Clark S.C., and Dinarello C.A. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75 (1990) 40
29. Sommer C. Cytokines and neuropathic pain. In: Hansson P., Fields H., Hill R., and Marchettini P. (Eds). Neuropathic Pain: Pathophysiology and Treatment vol. 21 (2001), IASP Press, Seattle, WA 37-62
30. Stout R.D., and Bottomby K.D. Antigen-specific activation of effector macrophages by IFN-γ producing (Th1) T-cell clones. Failure of TL-4 producing (Th2) T-cell clones to activate effector function in macrophages. Journal of Immunology 142 (1989) 760-765
31. Wagner H.M., Beuscher H.U., Rollingoff M., and Solbach W. Interferon-γ inhibits the efficacy of interleukin-1 to generate Th2-cell biased immune response induced by Leishmania major. Immunobiology 182 3-4 (1991) 292-306
32. Watkins L.R., Wiertelak E.P., Goehler L.E., Smith K.P., Martin D., and Maier S.F. Characterization of cytokine-induced hyperalgesia. Brain Research 654 1 (1994) 15-26
33. Yamamoto M., Yoshizaki K., Kishimoto T., and Ito H. IL-6 is required for the development of Th1 cell-mediated murine colitis. Journal of Immunology 164 9 (2000) 4878-4882
34. Zimmerman M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110