Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus

Journal of Biological Chemistry

Volumn 281, Issue 15, 2006, Pages 10035-10041

  Fuda, Cosimo ^a   Hesek, Dusan ^a   Lee, Mijoon ^a   Heilmayer, Werner ^b   Novak, Rodger ^b   Vakulenko, Sergei B ^a   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELLS; ENZYME INHIBITION; GENES; PROTEINS; RATE CONSTANTS;

CELL WALL; CEPHALOSPORIN ANTIBIOTICS; PENICILLIN-BINDING PROTEIN (PBP); STAPHYLOCOCCUS AUREUS;

ANTIBIOTICS;

ABR 1175; ABR 1974; ABR 2901; ABRI 1175; ABRI 1974; ABRI 2901; CEFEPIME; CEFTAZIDIME; CELL MEMBRANE PROTEIN; CEPHALOSPORIN DERIVATIVE; NITROCEFIN; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; METICILLIN; PENICILLIN BINDING PROTEIN;

ACYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL STRAIN; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME INHIBITION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANT STAPHYLOCOCCUS AUREUS; ANTIBIOTIC RESISTANCE; BINDING SITE; CELL WALL; CHEMICAL MODEL; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; DRUG EFFECT; KINETICS; METABOLISM; MOLECULAR CLONING; PENICILLIN RESISTANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; TIME; ULTRAVIOLET RADIATION;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CELL WALL; CEPHALOSPORINS; CIRCULAR DICHROISM; CLONING, MOLECULAR; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KINETICS; METHICILLIN; METHICILLIN RESISTANCE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PENICILLIN-BINDING PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS; TIME FACTORS; ULTRAVIOLET RAYS; VANCOMYCIN;

EID: 33744504974     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508846200     Document Type: Article

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