Plasma prohepcidin positively correlates with hematocrit in chronic hemodialysis patients

Blood Purification

Volumn 24, Issue 3, 2006, Pages 311-316

  Hsu, Shih Ping ^a,b   Chiang, Chih Kang ^a,b   Chien, Chiang Ting ^b   Hung, Kuan Yu ^a,b  

^a FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Anemia; Erythropoiesis; Hemodialysis; Hepcidin (prohepcidin); Iron profiles; Iron supplement; Proinflammatory cytokines

Indexed keywords

C REACTIVE PROTEIN; HEPCIDIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; IRON; IRON REGULATORY FACTOR; PROHEPCIDIN; RECOMBINANT ERYTHROPOIETIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ANEMIA; ARTICLE; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIESIS; FEMALE; HEMATOCRIT; HEMODIALYSIS; HORMONE DETERMINATION; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; ANTIMICROBIAL CATIONIC PEPTIDES; CHRONIC DISEASE; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIETIN; FEMALE; HEMATOCRIT; HUMANS; INFLAMMATION; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-6; IRON; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; RENAL DIALYSIS;

EID: 33744498373     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000091453     Document Type: Article

References (16)

1. National Kidney Foundation: K/DOQI Clinical Practice Guidelines for anemia of chronic kidney disease, 2000. Am J Kidney Dis 2001;37(suppl 1):S182-S283.
2. Locatelli F, Aljama P, Barany P, Canaud B, Carrera F, Eckardt KU, Horl WH, Macdougal IC, Macleod A, Wiecek A, Cameron S, European Best Practice Guidelines Working Group: Revised European Best Practice Guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant 2004;19(suppl 2):ii1-ii47.
3. Muirhead N, Hodsman AB: Occult infection and resistance of anaemia to rHuEPO therapy in renal failure. Nephrol Dial Transplant 1990;5:232-234.
4. Barany P, Divino-Filho JC, Bergstrom J: High C-reactive protein is a strong predictor of resistance to erythropoietin in hemodialysis patients. Am J Kidney Dis 1997;29:565-568.
5. Macdougall IC, Horl WH, Jacobs C, Valderrabano F, Parrondo I, Thompson K, Cremers S: European Best Practice Guidelines 6-8 assessing and optimizing iron stores. Nephrol Dial Transplant 2000;15(suppl 4):20-32.
6. Weiss G, Goodnough LT: Anemia of chronic disease. N Engl J Med 2005;352:1011-1023.
7. Park CH, Valore EV, Waring AJ, Ganz T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-7810.
8. Andrews NC: Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest 2004;113:1251-1253.
9. Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W: Prohepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anemia. Gut 2004;53:735-743.
10. Taes YE, Wuyts B, Boelaert JR, De Vriese AS, Delanghe JR: Prohepcidin accumulates in renal insufficiency. Clin Chem Lab Med 2004;42:387-389.
11. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S: The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-1044.
12. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T: IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-1276.
13. Lee P, Peng H, Gelbart T, Wang L, Beutler E: Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005;102:1906-1910.
14. Nicolas G, Viatte L, Bennoun M, Beaumont C, Kahn A, Vaulont S: Hepcidin, a new iron regulatory peptide. Blood Cells Mol Dis 2002;29:327-335.
15. Dallalio G, Fleury T, Means RT: Serum hepcidin in clinical specimens. Br J Hematol 2003;122:996-1000.
16. Brookes MJ, Sharma NK, Telesis C, Equal TH: Serum pro-hepcidin: measuring active hepcidin or a non-functional precursor? Gut 2004;53:735-743.