Role of T-cell receptor V beta 8.3 peptide vaccine in the prevention of experimental autoimmune uveoretinitis

Chinese Medical Journal

Volumn 119, Issue 9, 2006, Pages 740-748

  Zhang, Rui ^a   Yang, Pei Zeng ^a   Wu, Chang You ^a   Jin, Hao Li ^b   Li, Bing ^a   Huang, Xiang Kun ^a   Zhou, Hong Yan ^a   Gao, Yang ^a   Zhu, Lian Xiang ^a   Kijlstra, Aize ^c,d,e  

^a SUN YAT SEN UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Autoimmune; Peptide vaccine; T cell receptor; Uveoretinitis

Indexed keywords

CD4 ANTIGEN; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 2; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; AQUEOUS HUMOR; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE INFLAMMATION; FEMALE; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; LYMPH NODE; LYMPHOCYTE PROLIFERATION; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SPLEEN; SUPERNATANT; TH1 CELL; TH2 CELL; UVEORETINITIS; VACCINATION;

EID: 33744459972     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200605010-00006     Document Type: Article

References (34)

1. Gery I, Mochizuki M, Nussenblatt RB. Retinal specific antigens and immunopathogenic processes they provoke. Retinal Res 1986;5:75-109.
2. Hu LH, Redmond TM, Sanui H, Kuwabara T, McAllister CG, Wiggert B, et al. Rat T-cell lines specific to a nonimmunodominant determinant of a retinal protein (IRBP) produce uveoretinitis and pinealitis. Cell Immunol 1989;122:251-261.
3. Sasamoto Y, Kotake S, Yoshikawa K, Wiggert B, Gery I, Matsuda H. Interphotoreceptor retinoid-binding protein derived peptide can induce experimental autoimmune uveoretinitis in various rat strains. Curr Eye Res 1994;13:845-849.
4. Caspi RR, Sun B, Agarwal RK, Silver PB, Rizzo LV, Chan CC, et al. T cell mechanisms in experimental autoimmune uveoretinitis: susceptibility is a function of the cytokine response profile. Eye 1997;11:209-212.
5. Offner H, Adlard K, Bebo BF Jr, Schuster J, Burrows GG, Buenafe AC, et al. Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. J Immunol 1998; 161: 2178-2186.
6. Howell MD, Winters ST, Olee T, Powell HC, Carlo DJ, Brostoff SW. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 1990;247:1167-1169.
7. Vandenbark AA, Chou YK, Whitham R, Bourdette DN, Offner H. Effects of vaccination with T cell receptor peptides: epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide. Immunol Cell Biol 1998;76:83-90.
8. Vandenbark AA, Hashim G, Offner H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 1989;341:541-544.
9. Egwuagu CE, Bahmanyar S, Mahdi RM, Nussenblatt RB, Gery I, Caspi RR. Predominant usage of V beta 8.3 T cell receptor in a T cell line that induces experimental autoimmune uveoretinitis (EAU). Clin Immunol Immunopathol 1992;65:152-160.
10. Abe T, Satoh N, Nakajima A, Koizumi T, Tamada M, Sakuragi S. Characterization of a Potent Uveito-pathogenic Site Derived from Rat Phosducin. Exp Eye Res 1997;65:703-710.
11. Inoki T, Yamagami S, Sakai R, Isobe M, Tsuru T, Kawashima H. Suppression of experimental autoimmune uveoretinitis by anti-alphabeta TCR monoclonal antibody. Jpn J Ophthalmol 2002;46:518-524.
12. Zhang J, Medaer R, Stinissen P, Hafler D, Raus J. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 1993;261:1451-1454.
13. Beraud E, Kotake S, Caspi RR, Oddo SM, Chan CC, Gery I, et al. Control of experimental autoimmune uveoretinitis by low dose T cell vaccination. Cell Immunol 1992;140:112-122.
14. Zhang J, Raus J. T-cell vaccination in autoimmune diseases. From laboratory to clinic. Hum Immunol 1993;38:87-96.
15. Chluba J, Steeg C, Becker A, Wekerle H, Epplen JT. T cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes. Eur J Immunol 1989;19:279-284.
16. Vandenbark AA, Morgan E, Bartholomew R, Bourdette D, Whitham R, Carlo D, et al. TCR peptide therapy in human autoimmune diseases. Neurochem Res 2001;26:713-730.
17. Bridges SL Jr, Moreland LW. T-cell receptor peptide vaccination in the treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998;24:641-650.
18. β17 peptides. Arthritis Rheum 1998;41:1919-1929.
19. Stevens DB, Karpus WJ, Gould KE, Swanborg RH. Studies of V beta 8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis. J Neuroimmunol 1992;37:123-129.
20. Offner H, Hashim GA, Vandenbark AA. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 1991;251:430-432.
21. Whitham RH, Kotzin BL, Buenafe AC. Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides. J Neurosci Res 1993;35:115-128.
22. Morgan EE, Nardo CJ, Diveley JP, Kunin J, Bartholomew RM, Moss RB, et al. Vaccination with a CDR2 BV6S2/6S5 peptide in adjuvant induces peptide-specific T-cell responses in patients with multiple sclerosis. J Neurosci Res 2001;64:298-301.
23. Gold DP, Shroeder K, Golding A, Brostoff SW, Wilson DB. T-cell receptor peptides as immunotherapy for autoimmune disease. Crit Rev Immunol 1997;17: 507-510.
24. Kumar V, Tabibiazar R, Geysen HM, Sercarz E. Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls murine experimental autoimmune encephalomyelitis. J Immunol 1995;154: 1941-1950.
25. Vandenbark AA, Hashim GA, Offner H. T cell receptor peptides in treatment of autoimmune disease: rationale and potential. J Neurosci Res 1996;43:391-402.
26. Matsumoto Y, Tsuchida M, Hanawa H, Abo T. T cell receptor peptide therapy for autoimmune encephalomyelitis: stronger immunization is necessary of effective vaccination. Cell Immunol 1994;153:468-478.
27. Bourdette DN, Chou YK, Whitham RH, Buckner J, Kwon HJ, Nepom GT, et al. Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T cell receptor BV genes. J Immunol 1998;161:1034-1044.
28. Bourdette DN, Whitham RH, Chou YK, Morrison WJ, Atherton J, Kenny C, et al. Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides. J Immunol 1994;152:2510-2519.
29. Gold DP, Smith RA, Golding AB, Morgan EE, Dafashy T, Nelson J, et al. Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCRV beta 6 CDR2 peptide. J Neuroimmunol 1997;76:29-38.
30. Takeuchi M, Yokoi H, Tsukahara R, Sakai J, Usui M. Differentiation of Th1 and Th2 cells in lymph nodes and spleens of mice during experimental autoimmune uveoretinitis. Jpn J Ophthalmol 2001;45:463-469.
31. Barton K, McLauchlan MT, Calder VL, Lightman S. The kinetics of cytokine mRNA expression in the retina during experimental autoimmune uveoretinitis. Cell Immunol 1995;164:133-140.
32. Chou YK, Weinberg AD, Buenafe A, Bourdette DN, Whitham R, Kaleeba JA, et al. MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides: comparison with myelin basic protein-specific T cells. J Neurosci Res 1996;45:838-851.
33. Kumar V, Maglione J, Thatte J, Pederson B, Sercarz E, Ward ES. Induction of a type 1 regulatory CD4 T cell response following V beta 8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis. Int Immunol 2001;13: 835-841.
34. + T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens. J Immunol 1993;151:1627-1636.