Evaluation of the serotonin receptor blockers ketanserin and methiothepin on the pulmonary hypertensive responses of broilers to intravenously infused serotonin

Poultry Science

Volumn 85, Issue 4, 2006, Pages 777-786

  Chapman, M E ^a   Wideman Jr , R F ^a  

^a UNIVERSITY OF ARKANSAS   (United States)

Author keywords

Broiler; Ketanserin; Methiothepin; Pulmonary hypertension; Serotonin

Indexed keywords

BACTERIA (MICROORGANISMS);

15 HYDROXY 9ALPHA,11ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; KETANSERIN; METITEPINE; PROSTAGLANDIN ENDOPEROXIDE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN ANTAGONIST;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIRD DISEASE; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; CHICKEN; CLINICAL TRIAL; DRUG ANTAGONISM; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION;

ANIMALS; BLOOD PRESSURE; CHICKENS; HYPERTENSION, PULMONARY; INJECTIONS, INTRAVENOUS; KETANSERIN; MALE; METHIOTHEPIN; POULTRY DISEASES; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT2; SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 33646936059     PISSN: 00325791     EISSN: 15253171     Source Type: Journal    
DOI: 10.1093/ps/85.4.777     Document Type: Article

References (37)

1. Abenhaim, L., Y. Moride, F. Brenot, S. Rich, J. Benichou, X. Kurz, T. Higenbottam, C. Oakley, E. Wouters, M. Aubier, G. Simonneau, and B. Begaud. 1996. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N. Engl. J. Med. 335:609-616.
2. Barnes, N. M., and T. Sharp. 1999. A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152.
3. Besch, E. L., and H. Kadono. 1978. Cardiopulmonary responses to acute hypoxia in domestic fowl. Pages 71-78 in Respiratory Function in Birds Adult and Embryonic. J. Piiper, ed. Springer-Verlag, New York, NY.
4. Brenot, F., P. Herve, P. Petitpretz, F. Parent, P. Duroux, and G. Simmoneu. 1993. Primary pulmonary hypertension and fenfluramine use. Br. Heart J. 70:537-541.
5. Chapman, M. E., and R. F. Wideman, Jr. 2001. Pulmonary wedge pressures confirm pulmonary hypertension in broilers is initiated by an excessive pulmonary arterial (precapillary) resistance. Poult. Sci. 80:468-473.
6. Chapman, M. E., and R. F. Wideman, Jr. 2002. Hemodynamic responses of broiler pulmonary vasculature to intravenously infused serotonin. Poult. Sci. 81:231-238.
7. Choi, D. S., and L. Maroteaux. 1996. Immunohistochemical localisation of the serotonin 5-HT2B receptor in mouse gut, cardiovascular system, and brain. FEBS Lett 391:45-51.
8. Cox, C. P. 1985. Activation of washed chicken thrombocytes by 1-0-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphoryl choline (platelet activating factor). Comp. Biochem. Physiol. 82A:145-151.
9. Deuchar, G. A., M. N. Hicks, and M. R. MacLean. 2005. The role of 5-hydroxytryptamine in the control of pulmonary vascular tone in a rabbit model of pulmonary hypertension secondary to left ventricular dysfunction. Pulm. Pharmacol. Ther. 18:23-31.
10. Douglas, J. G., J. F. Munro, A. H. Kitchin, A. L. Muir, and A. T. Proudfoot. 1981. Pulmonary hypertension and fenfluramine. Br. Med. J. 283:881-883.
11. Eddahibi, S., N. Morrell, M. P. d'Ortho, R. Naeije, and S. Adnot. 2002. Pathobiology of pulmonary arterial hypertension. Eur. Respir. J. 20:1559-1572.
12. Engel, G., M. K. Gothert, D. Hoyer, E. Schlicker, and K. Hillebrand. 1986. Identity of inhibitory presynaptic 5-hydroxytryptamine autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch. Pharmacol. 357:1-7.
13. Fanburg, B. L., and S. L. Lee. 1997. A new role for an old molecule: Serotonin as a mitogen. Am. J. Physiol. 272:L795-L806.
14. Hervé, P., J. M. Launay, M. L. Scrobohaci, F. Brenot, G. Simonneau, P. Petitpretz, P. Poubeau, J. Cerrina, P. Duroux, and L. Drouet. 1995. Increased plasma serotonin in primary pulmonary hypertension. Am. J. Med. 99:249-254.
15. Julian, R. J. 1993. Ascites in poultry. Avian Pathol. 22:419-454.
16. Keegan, A., I. Morecroft, D. Smillie, M. N. Hicks, and M. R. MacLean. 2001. Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: Converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935. Circ. Res. 89:1231-1239.
17. Lacoste-Eleaume, A. S., C. Bleux, P. Quere, F. Coudert, C. Corbel, and C. Kanellopoulos-Langevin. 1994. Biochemical and functional characterization of an avian homolog of the integrin GPIIb-IIIa present on chicken thrombocytes. Exp. Cell Res. 213:198-209.
18. Launay, J. M., P. Hervé, K. K. Peoc'h, C. Tournois, J. Callebert, C. G. Nebigil, N. Etienne, L. Drouet, M. Humbert, G. Simonneau, L. Maroteaux, 2002. Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nature Med. 8:1129-1135.
19. Lee, S. L., W. W. Wang, J. J. Lanzillo, and B. L. Fanburg. 1994. Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture. Am. J. Physiol. 266:146-152.
20. MacLean, M., P. Hervé, S. Eddahibi, and S. Adnot. 2000. 5-hydroxytryptamine and the pulmonary circulation: Receptors, transporters and relevance to pulmonary arterial hypertension. Br. J. Pharmacol. 131:161-168.
21. MacLean, M., R. G. Sweeney, M. Baird, K. M. McCulloch, M. Houslay, and I. Morecroft. 1996. 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Br. J. Pharmacol. 119:917-930.
22. McGoon, M. D., and P. M. Vanhoutte. 1984. Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. J. Clin. Invest. 74:828-833.
23. Meyer, D. C., and P. D. Sturkie. 1974. Distribution of serotonin among blood cells of the domestic fowl. Proc. Soc. Exp. Biol. Med. 147:382-386.
24. Miao, C. Y., H. H. Xie, H. Yu, Z. X. Chu, and D. F. Su. 2003. Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 30:189-193.
25. Morecroft, I., R. P. Heeley, H. M. Prentice, A. Kirk, and M. R. MacLean. 1999. 5-HT receptors mediating contraction in human small pulmonary arteries: Importance of the 5-HT1B receptor. Br. J. Pharmacol. 128:730-734.
26. Ni, W., M. W. Li, K. Thakali, G. D. Fink, and S. W. Watts. 2004. The fenfluramine metabolite (+)-norfenfluramine is vasoactive. J. Pharmacol. Exp. Ther. 309:845-852.
27. Peacock, A. J., C. Picket, K. Morris, and J. T. Reeves. 1989. The relationship between rapid growth and pulmonary hemodynamics in the fast-growing broiler chicken. Am. Rev. Respir. Dis. 139:1524-1530.
28. Pitt, B. R., W. Weng, A. R. Steve, R. D. Blakely, I. Reynolds, and P. Davies. 1994. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. Am. J. Physiol. 266:L178-L186.
29. Seiler, K. U., O. Wassermann, and H. Wensky. 1974. On the role of serotonin in the pathogenesis of pulmonary hypertension induced by anorectic drugs, an experimental study in the isolated perfused rat lung. Clin. Exp. Pharmacol. Physiol. 1:463-471.
30. Sturkie, P. D. 1986. Body fluids: Blood. Pages 102-109 in Avian Physiology. 4th ed. P. J. Sturkie, ed. Springer-Verlag, New York, NY.
31. Vanhoutte, P., A. Amery, W. Birkenhager, A. Breckenridge, F. Buhler, A. Distler, J. Dormandy, A. Doyle, E. Frohlich, and L. Hansson. 1988. Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin. Hypertension 11:111-133.
32. Wideman, R. F. 2000. Cardio-pulmonary hemodynamics and ascites in broiler chickens. Poult. Avian Biol. Rev. 11:1-23.
33. Wideman, R. F., and W. G. Bottje. 1993. Current understanding of the ascites syndrome and future research directions. Pages 1-20 in Nutritional and Technical Symposium Proceedings. Novus International Inc., St. Louis, MO.
34. Wideman, R. F., G. F. Erf, and M. E. Chapman. 2001. Intravenous endotoxin triggers pulmonary vasoconstriction and pulmonary hypertension in broiler chickens. Poult. Sci. 80:647-655.
35. Wideman, R. F., Y. K. Kirby, M. F. Forman, N. Marson, R. W. McNew, and R. L. Owen. 1998. The infusion rate dependant influence of metabolic acidosis on pulmonary vascular resistance in broilers. Poult. Sci. 77:309-321.
36. Wideman, R. F., Y. K. Kirby, C. D. Tacket, N. E. Marson, and R. W. McNew. 1996. Cardio-pulmonary function during acute unilateral occlusion of the pulmonary artery in broilers fed diets containing normal or high levels of arginine-HCl. Poult. Sci. 79:257-264.
37. Wideman, R. F., P. Maynard, and W. G. Bottje. 1999. Thromboxane mimics the pulmonary but not systemic vascular responses to bolus HCl injections in broiler chickens. Poult. Sci. 78:714-721.