Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine

Human Gene Therapy

Volumn 17, Issue 5, 2006, Pages 518-530

  O'Brien, Tracey A ^a   Tuong, Dong T ^b   Basso, Lisa M ^b   Scott McIvor, R ^b,c   Orchard, Paul J ^b  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; CYTOSINE DEAMINASE; DRUG METABOLITE; FLUCYTOSINE; FLUOROURACIL; FLUOROURIDINE; NERVE GROWTH FACTOR RECEPTOR; RETROVIRUS VECTOR; URACIL PHOSPHORIBOSYLTRANSFERASE;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHIMERA; CONTROLLED STUDY; CYTOTOXICITY; DONOR; ENZYME ACTIVITY; FLOW CYTOMETRY; FUSION GENE; GENE CONSTRUCT; GENE EXPRESSION; GENETIC TRANSDUCTION; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; SACCHAROMYCES CEREVISIAE; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

CELL LINE; CELL PROLIFERATION; CYTOSINE DEAMINASE; ESCHERICHIA COLI; FLUCYTOSINE; GENES, TRANSGENIC, SUICIDE; GENETIC VECTORS; HUMANS; PENTOSYLTRANSFERASES; PYRIMIDINES; RECEPTOR, NERVE GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RETROELEMENTS; SACCHAROMYCES CEREVISIAE; T-LYMPHOCYTES; TRANSDUCTION, GENETIC;

SACCHAROMYCES CEREVISIAE; SIMPLEXVIRUS;

EID: 33646932934     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2006.17.518     Document Type: Article

References (37)

1. BONINI, C., FERRARI, G., VERZELETTI, S., SERVIDA, P., ZAPPONE, E., RUGGIERI, L., PONZONI, M., ROSSINI, S., MAVILIO, F., TRAVERSARI, C., and BORDIGNON, C. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724.
2. CHENG, Y.C., GRILL, S.P., DUTSCHMAN, G.E., NAKAYAMA, K., and BASTOW, K.F. (1983). Metabolism of 9-(1,3-dihydroxy-2-propoxymethyOguanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells. J. Biol. Chem. 258, 12460-12464.
3. COHEN, J.L., BOYER, O., and KLATZMANN, D. (2001). Suicide gene therapy of graft-versus-host disease: Immune reconstitution with transplanted mature T cells. Blood 98, 2071-2076.
4. DAVIES, S.M., KHAN, S., WAGNER, J.E., ARTHUR, D.C., AUERBACH, A.D., RAMSAY, N.K., and WEISDORF, D.J. (1996). Un-related donor bone marrow transplantation for Fanconi anemia. Bone Marrow Transplant. 17, 43-47.
5. DAVIES, S.M., KOLLMAN, C., ANASETTI, C., ANTIN, J.H., GAJEWSKI, J., CASPER, J.T., NADEMANEE, A., NOREEN, H., KING, R., CONFER, D., and KERNAN, N.A. (2000). Engraftment and survival after unrelated-donor bone marrow transplantation: A report from the national marrow donor program. Blood 96, 4096-4102.
6. DIASIO, R.B. (1998). The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology [review]. Oncology 12, 23-27.
7. DONALD, R.G., and ROOS, D.S. (1995). Insertional mutagenesis and marker rescue in a protozoan parasite: Cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii. Proc. Natl. Acad. Sci. U.S.A. 92, 5749-5753.
8. ERBS, P., REGULIER, E., KINTZ, J., LEROY, P., POITEVIN, Y., EXINGER, F., JUND, R., and MEHTALI, M. (2000). In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene. Cancer Res. 60, 3813-3822.
9. FOLEY, G.E., LAZARUS, H., FARBER, S., UZMAN, B.C., BOONE, B.A., and MCCARTHY, R.E. (1965). Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia. Cancer 18, 522-529.
10. GARIN, M.I., GARRETT, E., TIBERGHIEN, P., APPERLEY, J.F., CHALMERS, D., MELO, J.V., and FERRAND, C. (2001). Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene. Blood 97, 122-129.
11. HAMSTRA, D.A., RICE, D.J., FAHMY, S., ROSS, B.D., and REHEMTULLA, A. (1999). Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase. Hum. Gene Ther. 10, 1993-2003.
12. HESDORFFER, C., WARD, M., MARKOWITZ, D., and BANK, A. (1990). Efficient gene transfer in live mice using a unique retroviral packaging line. DNA Cell Biol. 9, 717-723.
13. KERN, L., DE MONTIGNY, J., JUND, R., and LACROUTE, F. (1990). The FUR1 gene of Saccharomyces cerevisiae: Cloning, structure and expression of wild-type and mutant alleles. Gene 88, 149-157.
14. KERNAN, N.A., BARTSCH, G., ASH, R.C., BEATTY, P.G., CHAMPLIN, R., FILIPOVICH, A., GAJEWSKI, J., HANSEN, J.A., HENSLEE-DOWNEY, J., McCULLOUGH, J., McGLAVE, P., PERKINS, H.A., PHILLIPS, G.L., SANDERS, J., STRONCEK, G., THOMAS, E.D., and BLUME, K.G. (1993). Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N. Engl. J. Med. 328, 593-602.
15. LEWIS, V.A., BASSO, L., BLAKE, N., SALO, J., LUND, T.C., McIVOR, R.S., and ORCHARD, P.J. (2003). Human nerve growth factor receptor and cytosine deaminase fusion genes. Hum. Gene Ther. 14, 1009-1016.
16. LONGLEY, D.B., HARKIN, D.P., and JOHNSTON, P.G. (2003). 5-fluorouracil: Mechanisms of action and clinical strategies. Nat. Rev. Cancer 3, 330-338.
17. MARMONT, A.M., HOROWITZ, M.M., GALE, R.P., SOBOCINSKI, K., ASH, R.C., VAN BEKKUM, D.W., CHAMPLIN, R.E., DICKE, K.A., GOLDMAN, J.M., GOOD, R.A., HERZIG, R.H., HONG, R., MASAOKA, T., RIMM, A.A., RINGDEN, O., SPECK, B., WEINER, R.S., and BORTIN, M.M. (1991). T-cell depletion of HLA-identical transplants in leukemia. Blood 78, 2120-2130.
18. MARTIN, P.J., HANSEN, J.A., BUCKNER, C.D., SANDERS, J.E., DEEG, H.J., STEWART, P., APPELBAUM, F.R., CLIFT, R., FEFER, A., WITHERSPOON, R.P., KENNEDY, M.S., SULLIVAN, K.M., FLOURNOY, N., STORB, R., and THOMAS, E.D. (1985). Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Blood 66, 664-672.
19. McIVOR, R.S., WOHLHUETER, R.M., and PLAGEMANN, P.G. (1983). Uracil phosphoribosyltransferase from Acholeplasma laid-lawü: Partial purification and kinetic properties. J. Bacteriol. 156, 192-197.
20. McIVOR, R.S., WOHLHUETER, R.M., and PLAGEMANN, P.P. (1985). Uridine phosphorylase from Novikoff rat hepatoma cells: Purification, kinetic properties, and its role in uracil anabolism. J. Cell. Physiol. 122, 397-404.
21. MILANO, G., ETIENNE, M.C., PIERREFITE, V., BARBERI-HEYOB, M., DEPORTE-FETY, R., and RENEE, N. (1999). Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity. Br. J. Cancer 79, 627-630.
22. MILLER, A.D., GARCIA, J.V., VON SUHR, N., LYNCH, C.M., WILSON, C., and EIDEN, M.V. (1991). Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J. Virol. 65, 2220-2224.
23. ORCHARD, P.J., BLAZAR, B.R., BURGER, S., LEVINE, B., BASSO, L., NELSON, D.M., GORDON, K., McIVOR, R.S., WAGNER, J.E., and MILLER, J.S. (2002). Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor. Hum. Gene Ther. 13, 979-988.
24. PAWELEC, G., BOROWITZ, A., KRAMMER, P.H., and WERNET, P. (1982). Constitutive interleukin 2 production by the JURKAT human leukemic T cell line. Eur. J. Immunol. 12, 387-392.
25. RAMNARAINE, M., PAN, W., GOBLIRSCH, M., LYNCH, C., LEWIS, V., ORCHARD, P., MANTYH, P., and CLOHISY, D.R. (2003). Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Res. 63, 6847-6854.
26. RIDDELL, S.R., ELLIOTT, M., LEWINSOHN, D.A., GILBERT, M.J., WILSON, L., MANLEY, S.A., LUPTON, S.D., OVERELL, R.W., REYNOLDS, T.C., COREY, L., and GREENBERG, P.D. (1996). T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat. Med. 2, 216-223.
27. SCHWARTZ, P.M., MOIR, R.D., HYDE, C.M., TUREK, P.J., and HANDSCHUMACHER, R.E. (1985). Role of uridine phosphorylase in the anabolism of 5-fluorouracil. Biochem. Pharmacol. 34, 3585-3589.
28. SENTER, P.D., SU, P.C., KATSURAGI, T., SAKAI, T., COSAND, W.L., HELLSTROM, I., and HELLSTROM, K.E. (1991). Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibodycytosine deaminase conjugates. Bioconjug. Chem. 2, 447-451.
29. +-enriched peripheral blood progenitor cells. Cancer Gene Ther. 8, 966-973.
30. THOMAS, D.M., and ZALCBERG, J.R. (1998). 5-fluorouracil: A pharmacological paradigm in the use of cytotoxics. Clin. Exp. Pharmacol. Physiol. 25, 887-895.
31. THOMAS-VASLIN, V., BELLIER, B., COHEN, J.L., BOYER, O., RAYNAL-RASCHILAS, N., GLOTZ, D., and KLATZMANN, D. (2000). Prolonged allograft survival through conditional and specific ablation of alloreactive T cells expressing a suicide gene. Transplantation 69, 2154-2161.
32. TIBERGHIEN, P. (2001). Use of suicide gene-expressing donor T-cells to control alloreactivity after haematopoietic stem cell transplantation. J. Intern. Med. 249, 369-377.
33. TIBERGHIEN, P., FERRAND, C., LIOURE, B., MILPIED, N., ANGONIN, R., DECONINCK, E., CERTOUX, J.M., ROBINET, E., SAAS, P., PETRACCA, B., JUTTNER, C., REYNOLDS, C.W., LONGO, D.L., HERVE, P., and CAHN, J.Y. (2001). Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97, 63-72.
34. VERZELETTI, S., BONINI, C., MARKTEL, S., NOBILI, N., CICERI, F., TRAVERSARI, C., and BORDIGNON, C. (1998). Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus- leukemia: Clinical follow-up and improved new vectors. Hum. Gene Ther. 9, 2243-2251.
35. VON KALLE, C., KIEM, H.P., GOEHLE, S., DAROVSKY, B., HEIMFELD, S., TOROK-STORB, B., STORB, R., and SCHUENING, F.G. (1994). Increased gene transfer into human hematopoietic progenitor cells by extended in vitro exposure to a pseudotyped retroviral vector. Blood 84, 2890-2897.
36. WALLACE, P.M., MACMASTER, J.F., SMITH, V.F., KERR, D.E., SENTER, P.D., and COSAND, W.L. (1994). Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res. 54, 2719-2723.
37. WOHLHUETER, R.M., McIVOR, R.S., and PLAGEMANN, P.G. (1980). Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells. J. Cell. Physiol. 104, 309-319.