메뉴 건너뛰기




Volumn 21, Issue 5, 2006, Pages 805-813

Effect of chronic dietary ethanol in the promotion of N- nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats

Author keywords

Chronic alcohol consumption; CYP2E1; Esophageal cancer; N nitrosomethylbenzylamine; Squamous cell carcinoma

Indexed keywords

ALCOHOL; CYTOCHROME P450 2E1; N BENZYL N METHYLNITROSAMINE;

EID: 33646928461     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2005.04040.x     Document Type: Article
Times cited : (12)

References (51)
  • 1
    • 0042835508 scopus 로고    scopus 로고
    • The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: An overview
    • Rehm J Room R Graham K Monteiro M Gmel G Sempos CT The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview Addiction 2003 98 1209 28
    • (2003) Addiction , vol.98 , pp. 1209-1228
    • Rehm, J.1    Room, R.2    Graham, K.3    Monteiro, M.4    Gmel, G.5    Sempos, C.T.6
  • 2
    • 0037505866 scopus 로고    scopus 로고
    • Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers
    • Yokoyama A Omori T Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers Jpn JClinOncol 2003 33 111 21
    • (2003) Jpn JClinOncol , vol.33 , pp. 111-121
    • Yokoyama A1    Omori, T.2
  • 3
    • 0028678071 scopus 로고
    • Ethanol metabolism in the gastrointestinal tract and its possible consequences
    • Seitz HK Gartner U Egerer G Simanowski UA Ethanol metabolism in the gastrointestinal tract and its possible consequences Alcohol AlcoholSuppl 1994 2 157 62
    • (1994) Alcohol AlcoholSuppl , vol.2 , pp. 157-162
    • Seitz H, K.1    Gartner, U.2    Egerer, G.3    Simanowski, U.A.4
  • 4
    • 0026328763 scopus 로고
    • Epidemiology and clinical aspects of esophageal cancer
    • Van Cutsem E Vantrappen G Epidemiology and clinical aspects of esophageal cancer JBelge Radiol 1991 74 365 8
    • (1991) JBelge Radiol , vol.74 , pp. 365-368
    • Van Cutsem, E.1    Vantrappen, G.2
  • 5
    • 1842763195 scopus 로고    scopus 로고
    • Risk factors for esophageal cancer in Coimbatore, southern India: A hospital-based case-control study
    • Chitra S Ashok L Anand L Srinivasan V Jayanthi V Risk factors for esophageal cancer in Coimbatore, southern India: a hospital-based case-control study Indian JGastroenterol 2004 23 19 21
    • (2004) Indian JGastroenterol , vol.23 , pp. 19-21
    • Chitra S1    Ashok, L.2    Anand, L.3    Srinivasan, V.4    Jayanthi, V.5
  • 7
    • 0027015818 scopus 로고
    • Alcohol acts to promote incidence of tumors
    • Mufti SI Alcohol acts to promote incidence of tumors Cancer DetectPrev 1992 16 157 62
    • (1992) Cancer DetectPrev , vol.16 , pp. 157-162
    • Mufti S, I.1
  • 8
    • 0002127550 scopus 로고
    • Alcohol and cancers of the esophagus and liver
    • In*Yirmiya R. *Tayler A.N. CRC Press Boca Raton eds
    • Mufti SI Alcohol and cancers of the esophagus and liver In Yirmiya R Tayler AN eds Alcohol, Immunity and Cancer Boca Raton CRC Press 1992 159 86
    • (1992) Alcohol, Immunity and Cancer , pp. 159-186
    • Mufti S, I.1
  • 9
    • 0018890929 scopus 로고
    • The proportion of cancer attributable to alcohol consumption
    • Rothman K The proportion of cancer attributable to alcohol consumption PrevMed 1980 9 174 9
    • (1980) PrevMed , vol.9 , pp. 174-179
    • Rothman K1
  • 10
    • 4244217529 scopus 로고
    • Alcohol and hepatic carcinogenesis
    • In*Yirmiya R. *Tayler A.N. CRC Press Boca Raton eds
    • Takada A Takase S Tsutsumi M Alcohol and hepatic carcinogenesis In Yirmiya R Tayler AN eds Alcohol, Immunity and Cancer Boca Raton CRC Press 1992 187 209
    • (1992) Alcohol, Immunity and Cancer , pp. 187-209
    • Takada A1    Takase, S.2    Tsutsumi, M.3
  • 11
    • 1842409036 scopus 로고    scopus 로고
    • Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases
    • Lieber CS Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases AdvPharmacol 1997 38 601 28
    • (1997) AdvPharmacol , vol.38 , pp. 601-628
    • Lieber C, S.1
  • 12
    • 0024586569 scopus 로고
    • Chemiluminescence from acetaldehyde oxidation by xanthine oxidase involves generation of and interactions with hydroxyl radicals
    • Puntarulo S Cederbaum AI Chemiluminescence from acetaldehyde oxidation by xanthine oxidase involves generation of and interactions with hydroxyl radicals AlcoholClinExpRes 1989 13 84 90
    • (1989) AlcoholClinExpRes , vol.13 , pp. 84-90
    • Puntarulo S1    Cederbaum, A.I.2
  • 13
    • 0029071258 scopus 로고
    • Early biochemical markers of effects: Enzyme induction, oncogene activation and markers of oxidative damage
    • Poulsen HE Loft S Early biochemical markers of effects: enzyme induction, oncogene activation and markers of oxidative damage Toxicology 1995 101 55 64
    • (1995) Toxicology , vol.101 , pp. 55-64
    • Poulsen H, E.1    Loft, S.2
  • 14
    • 2442679411 scopus 로고    scopus 로고
    • Expression of cytochrome P450 in tumor tissues and its association with cancer development
    • Oyama T Kagawa N Kunugita N et al. Expression of cytochrome P450 in tumor tissues and its association with cancer development FrontBiosci 2004 9 1967 76
    • (2004) FrontBiosci , vol.9 , pp. 1967-1976
    • Oyama T1    Kagawa, N.2    Kunugita, N.3
  • 15
    • 0038740798 scopus 로고    scopus 로고
    • Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans
    • Ryu SD Chung WG Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans Food ChemToxicol 2003 41 861 6
    • (2003) Food ChemToxicol , vol.41 , pp. 861-866
    • Ryu S, D.1    Chung, W.G.2
  • 16
    • 0027731547 scopus 로고
    • Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease
    • Ingelman-Sundberg M Johansson I Yin H et al. Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease Alcohol 1993 10 447 52
    • (1993) Alcohol , vol.10 , pp. 447-452
    • Ingelman-Sundberg M1    Johansson, I.2    Yin, H.3
  • 17
    • 0024244103 scopus 로고
    • Human ethanol-inducible P450IIE1: Complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression
    • Umeno M McBride OW Yang CS Gelboin HV Gonzalez FJ Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression Biochemistry 1988 27 9006 13
    • (1988) Biochemistry , vol.27 , pp. 9006-9013
    • Umeno M1    McBride, O.W.2    Yang, C.S.3    Gelboin, H.V.4    Gonzalez, F.J.5
  • 18
    • 0023160650 scopus 로고
    • The microsomal ethanol oxidizing system and its interaction with other drugs, carcinogens, and vitamins
    • Lieber CS Lasker JM Alderman J Leo MA The microsomal ethanol oxidizing system and its interaction with other drugs, carcinogens, and vitamins AnnNYAcadSci 1987 492 11 24
    • (1987) AnnNYAcadSci , vol.492 , pp. 11-24
    • Lieber C, S.1    Lasker, J.M.2    Alderman, J.3    Leo, M.A.4
  • 20
    • 0026567713 scopus 로고
    • Oxidative and reactive metabolism by cytochrome P4502E1
    • Koop DR Oxidative and reactive metabolism by cytochrome P4502E1 FASEB J 1992 6 724 30
    • (1992) FASEB J , vol.6 , pp. 724-730
    • Koop D, R.1
  • 21
    • 0026484237 scopus 로고
    • Catalytic properties of the human cytochrome P4502E1 produced by cDNA expression in mammalian cells
    • Patten CJ Ishizaki H Aoyama T et al. Catalytic properties of the human cytochrome P4502E1 produced by cDNA expression in mammalian cells ArchBiochemBiophys 1992 299 163 71
    • (1992) ArchBiochemBiophys , vol.299 , pp. 163-171
    • Patten C, J.1    Ishizaki, H.2    Aoyama, T.3
  • 22
    • 0025048632 scopus 로고
    • Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract
    • Shimizu M Lasker JM Tsutsumi M Lieber CS Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract Gastroenterology 1990 99 1044 53
    • (1990) Gastroenterology , vol.99 , pp. 1044-1053
    • Shimizu M1    Lasker, J.M.2    Tsutsumi, M.3    Lieber, C.S.4
  • 23
    • 0032403096 scopus 로고    scopus 로고
    • Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine induced esophageal carcinogenesis in zinc-deficient rats: Effects on esophageal cell proliferation and apoptosis
    • Fong LY Pegg AE Magee PN Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine induced esophageal carcinogenesis in zinc-deficient rats: effects on esophageal cell proliferation and apoptosis Cancer Res 1998 58 5380 8
    • (1998) Cancer Res , vol.58 , pp. 5380-5388
    • Fong L, Y.1    Pegg, A.E.2    Magee, P.N.3
  • 24
    • 0031419679 scopus 로고    scopus 로고
    • Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): Analysis of cell proliferation, and mutations in H-ras and p53 genes
    • Fong LY Lau KM Huebner K Magee PN Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes Carcinogenesis 1997 18 1477 84
    • (1997) Carcinogenesis , vol.18 , pp. 1477-1484
    • Fong L, Y.1    Lau, K.M.2    Huebner, K.3    Magee, P.N.4
  • 25
    • 0027235830 scopus 로고
    • In vivo induction of hepatic P4502E1 by ethanol: Role of increased enzyme synthesis
    • Tsutsumi M Lasker JM Takahashi T Lieber CS In vivo induction of hepatic P4502E1 by ethanol: role of increased enzyme synthesis ArchBiochemBiophys 1993 304 209 18
    • (1993) ArchBiochemBiophys , vol.304 , pp. 209-218
    • Tsutsumi M1    Lasker, J.M.2    Takahashi, T.3    Lieber, C.S.4
  • 26
    • 0032898867 scopus 로고    scopus 로고
    • Ultra-sensitive method for determination of ethanol in whole blood by headspace capillary gas chromatography with cryogenic oven trapping
    • Watanabe-Suzuki K Seno H Ishii A Kumazawa T Suzuki O Ultra-sensitive method for determination of ethanol in whole blood by headspace capillary gas chromatography with cryogenic oven trapping JChromatogrBBiomedSciAppl 1999 727 89 94
    • (1999) JChromatogrBBiomedSciAppl , vol.727 , pp. 89-94
    • Watanabe-Suzuki K1    Seno, H.2    Ishii, A.3    Kumazawa, T.4    Suzuki, O.5
  • 27
    • 0024378451 scopus 로고
    • The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver
    • Tsutsumi M Lasker JM Shimizu M Rosman AS Lieber CS The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver Hepatology 1989 10 437 46
    • (1989) Hepatology , vol.10 , pp. 437-446
    • Tsutsumi M1    Lasker, J.M.2    Shimizu, M.3    Rosman, A.S.4    Lieber, C.S.5
  • 28
    • 0036525588 scopus 로고    scopus 로고
    • Epidemiologic trends in esophageal and gastric cancer in the United States
    • Brown LM Devesa SS Epidemiologic trends in esophageal and gastric cancer in the United States SurgOncolClinNorth Am 2002 11 235 56
    • (2002) SurgOncolClinNorth Am , vol.11 , pp. 235-256
    • Brown L, M.1    Devesa, S.S.2
  • 30
    • 0034060295 scopus 로고    scopus 로고
    • Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus
    • Franceschi S Bidoli E Negri E et al. Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus IntJCancer 2000 86 626 31
    • (2000) IntJCancer , vol.86 , pp. 626-631
    • Franceschi S1    Bidoli, E.2    Negri, E.3
  • 31
    • 0035092599 scopus 로고    scopus 로고
    • Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries
    • Carlton PS Kresty LA Siglin JC et al. Inhibition of N- nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries Carcinogenesis 2001 22 441 6
    • (2001) Carcinogenesis , vol.22 , pp. 441-446
    • Carlton P, S.1    Kresty, L.A.2    Siglin, J.C.3
  • 32
    • 0033779067 scopus 로고    scopus 로고
    • Chemopreventive effect of curcumin on N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats
    • Ushida J Sugie S Kawabata K et al. Chemopreventive effect of curcumin on N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats Jpn JCancer Res 2000 91 893 8
    • (2000) Jpn JCancer Res , vol.91 , pp. 893-898
    • Ushida J1    Sugie, S.2    Kawabata, K.3
  • 33
    • 0018178388 scopus 로고
    • Pathology of esophageal neoplasms and associated proliferative lesions in rats by N-methyl-N-benzylnitrosamine
    • Stinson SF Squire RA Sporn MB Pathology of esophageal neoplasms and associated proliferative lesions in rats by N-methyl-N-benzylnitrosamine JNatl Cancer Inst 1978 61 1471 5
    • (1978) JNatl Cancer Inst , vol.61 , pp. 1471-1475
    • Stinson S, F.1    Squire, R.A.2    Sporn, M.B.3
  • 34
    • 0023006249 scopus 로고
    • Nitrosamines and nitrosamine precursors in foods from Linxian, China, a high incidence area for esophageal cancer
    • Singer GM Chuan J Roman J Min-Hsin L Lijinsky W Nitrosamines and nitrosamine precursors in foods from Linxian, China, a high incidence area for esophageal cancer Carcinogenesis 1986 7 733 6
    • (1986) Carcinogenesis , vol.7 , pp. 733-736
    • Singer G, M.1    Chuan, J.2    Roman, J.3    Min-Hsin, L.4    Lijinsky, W.5
  • 35
    • 0019271591 scopus 로고
    • Recent progress in research on esophageal cancer in China
    • Li MH Li P Li PJ Recent progress in research on esophageal cancer in China AdvCancer Res 1980 33 173 249
    • (1980) AdvCancer Res , vol.33 , pp. 173-249
    • Li M, H.1    Li, P.2    Li, P.J.3
  • 36
    • 0036128317 scopus 로고    scopus 로고
    • Dynamics of cytochrome P4502E1 activity in man: Induction by ethanol and disappearance during withdrawal phase
    • Oneta CM Lieber CS Li J et al. Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase JHepatol 2002 36 47 52
    • (2002) JHepatol , vol.36 , pp. 47-52
    • Oneta C, M.1    Lieber, C.S.2    Li, J.3
  • 37
    • 0035162101 scopus 로고    scopus 로고
    • Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1
    • Liu C Russell RM Seitz HK Wang XD Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1 Gastroenterology 2001 120 179 89
    • (2001) Gastroenterology , vol.120 , pp. 179-189
    • Liu C1    Russell, R.M.2    Seitz, H.K.3    Wang, X.D.4
  • 38
    • 0029618909 scopus 로고
    • Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1
    • 32 5
    • Roberts BJ Song BJ Soh Y Park SS Shoaf SE Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1 JBiolChem 1995 270 29 32 5
    • (1995) JBiolChem , vol.270 , pp. 29
    • Roberts B, J.1    Song, B.J.2    Soh, Y.3    Park, S.S.4    Shoaf, S.E.5
  • 39
    • 0032929455 scopus 로고    scopus 로고
    • Expression of cytochrome P450 2A3 in rat esophagus: Relevance to N-nitrosobenzylmethylamine
    • Gopalakrishnan R Morse MA Lu J et al. Expression of cytochrome P450 2A3 in rat esophagus: relevance to N-nitrosobenzylmethylamine Carcinogenesis 1999 20 885 91
    • (1999) Carcinogenesis , vol.20 , pp. 885-891
    • Gopalakrishnan R1    Morse, M.A.2    Lu, J.3
  • 40
    • 0026484237 scopus 로고
    • Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells
    • Patten CJ Ishizaki H Aoyama T et al. Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells ArchBiochemBiophys 1992 299 163 71
    • (1992) ArchBiochemBiophys , vol.299 , pp. 163-171
    • Patten C, J.1    Ishizaki, H.2    Aoyama, T.3
  • 41
    • 0029741969 scopus 로고    scopus 로고
    • Mechanisms of nitrosamine bioactivation and carcinogenesis
    • Yang CS Smith TJ Mechanisms of nitrosamine bioactivation and carcinogenesis AdvExpMedBiol 1996 387 385 94
    • (1996) AdvExpMedBiol , vol.387 , pp. 385-394
    • Yang C, S.1    Smith, T.J.2
  • 42
    • 0024494974 scopus 로고
    • Effect of chronic dietary ethanol consumption on the initiation and promotion of chemically-induced esophageal carcinogenesis in experimental rats
    • Mufti SI Becker G Spite IG Effect of chronic dietary ethanol consumption on the initiation and promotion of chemically-induced esophageal carcinogenesis in experimental rats Carcinogenesis 1989 10 303 9
    • (1989) Carcinogenesis , vol.10 , pp. 303-309
    • Mufti S, I.1    Becker, G.2    Spite, I.G.3
  • 43
    • 0036729009 scopus 로고    scopus 로고
    • Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis
    • Kaneko M Morimura K Nishikawa T et al. Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis OncolReport 2002 9 1069 73
    • (2002) OncolReport , vol.9 , pp. 1069-1073
    • Kaneko M1    Morimura, K.2    Nishikawa, T.3
  • 44
    • 0036001272 scopus 로고    scopus 로고
    • Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver
    • Mori Y Koide A Kobayashi Y Morimura K Kaneko M Fukushima S Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver Mutagenesis 2002 17 251 6
    • (2002) Mutagenesis , vol.17 , pp. 251-256
    • Mori Y1    Koide, A.2    Kobayashi, Y.3    Morimura, K.4    Kaneko, M.5    Fukushima, S.6
  • 45
    • 0037047562 scopus 로고    scopus 로고
    • Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus
    • Gopalakrishnan R Gupta A Carlton PS Morse MA Stoner GD Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus JToxicolEnvironHealth A 2002 65 1077 91
    • (2002) JToxicolEnvironHealth a , vol.65 , pp. 1077-1091
    • Gopalakrishnan R1    Gupta, A.2    Carlton, P.S.3    Morse, M.A.4    Stoner, G.D.5
  • 46
    • 0141563790 scopus 로고    scopus 로고
    • Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers
    • Yokoyama M Yokoyama A Yokoyama T et al. Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers AlcoholClinExpRes 2003 27 1395 401
    • (2003) AlcoholClinExpRes , vol.27 , pp. 1395-1401
    • Yokoyama M1    Yokoyama, A.2    Yokoyama, T.3
  • 47
    • 0033915067 scopus 로고    scopus 로고
    • Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients
    • Muto M Hitomi Y Ohtsu A Ebihara S Yoshida S Esumi H Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients Gut 2000 47 256 61
    • (2000) Gut , vol.47 , pp. 256-261
    • Muto M1    Hitomi, Y.2    Ohtsu, A.3    Ebihara, S.4    Yoshida, S.5    Esumi, H.6
  • 48
    • 0032744951 scopus 로고    scopus 로고
    • Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics
    • Yokoyama A Muramatsu T Omori T et al. Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics AlcoholClinExpRes 1999 23 1705 10
    • (1999) AlcoholClinExpRes , vol.23 , pp. 1705-1710
    • Yokoyama A1    Muramatsu, T.2    Omori, T.3
  • 49
    • 0031709015 scopus 로고    scopus 로고
    • Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics
    • Yokoyama A Muramatsu T Ohmori T et al. Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics Carcinogenesis 1998 19 1383 7
    • (1998) Carcinogenesis , vol.19 , pp. 1383-1387
    • Yokoyama A1    Muramatsu, T.2    Ohmori, T.3
  • 50
    • 0031045241 scopus 로고    scopus 로고
    • Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms
    • Coutelle C Ward PJ Fleury B et al. Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms HumGenet 1997 99 319 25
    • (1997) HumGenet , vol.99 , pp. 319-325
    • Coutelle C1    Ward, P.J.2    Fleury, B.3
  • 51
    • 0027200395 scopus 로고
    • Genetic factors in alcohol metabolism and alcoholism
    • Bosron WF Ehrig T Li TL Genetic factors in alcohol metabolism and alcoholism SeminLiver Dis 1993 13 126 35
    • (1993) SeminLiver Dis , vol.13 , pp. 126-135
    • Bosron W, F.1    Ehrig, T.2    Li, T.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.