'Ground truth' for selection on CCR5-Δ32

Trends in Genetics

Volumn 22, Issue 6, 2006, Pages 293-296

  Hedrick, Philip W ^a   Verrelli, Brian C ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CLINICAL OBSERVATION; GENE DELETION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC RESISTANCE; GENETIC SELECTION; GENETIC VARIABILITY; GENOME; HETEROZYGOSITY; HUMAN; MEDICAL EXAMINATION; PLAGUE; POPULATION; PRIORITY JOURNAL; SAMPLE; SHORT SURVEY; SMALLPOX;

ALLELES; EVOLUTION, MOLECULAR; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOME, HUMAN; GERMANY; HIV INFECTIONS; HUMANS; LINKAGE DISEQUILIBRIUM; PALEONTOLOGY; PLAGUE; RECEPTORS, CCR5; SEQUENCE DELETION; SMALLPOX;

VARIOLA VIRUS;

EID: 33646900243     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2006.04.007     Document Type: Short Survey

References (24)

1. Stephens J.C., et al. Dating the origin of the CCR5-Δ32 AIDS-resistance allele by the coalescence of haplotypes. Am. J. Hum. Genet. 62 (1998) 1507-1515
2. Galvani A.P., and Slatkin M. Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 15276-15279
3. Hummel S., et al. Detection of the CCR5-Δ32 HIV resistance gene in Bronze Age skeletons. Genes Immun. 6 (2005) 371-374
4. Sabeti P.C., et al. The case for selection at CCR5-Δ32. PLoS Biol. 3 (2005) 1963-1969
5. Novembre J., et al. The geographic spread of the CCR5 Δ32 HIV-resistance allele. PLoS Biol. 3 (2005) 1954-1962
6. McCarroll S.A., et al. Common deletion polymorphisms in the human genome. Nat. Genet. 38 (2006) 86-92
7. Garrigan D., and Hedrick P.W. Perspective: Detecting adaptive molecular evolution, lessons from the MHC. Evolution 57 (2003) 1707-1722
8. Galvani A.P., and Novembre J. The evolutionary history of the CCR5-Δ32 HIV-resistance mutation. Microbes Infect. 7 (2005) 302-309
9. Carrington M., et al. Novel alleles of the chemokine-receptor gene CCR5. Am. J. Hum. Genet. 61 (1997) 1261-1267
10. Bamshad M.J., et al. A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 10539-10544
11. Wang X., et al. Gene losses during human origins. PLoS Biol. 4 (2006) 366-377
12. Chen Z., et al. Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus. J. Exp. Med. 188 (1998) 2057-2065
13. Veazey R., et al. Decrease CCR5 expression on CD4+ T cells of SIV-infected sooty mangabeys. AIDS Res. Hum. Retroviruses 19 (2003) 227-233
14. Verrelli B.C., et al. Evidence for balancing selection from nucleotide sequence analyses of human G6PD. Am. J. Hum. Genet. 71 (2002) 1112-1128
15. de Silva E., and Stumpf M.P.H. HIV and the CCR5-Δ32 resistance allele. FEMS Microbiol. Lett. 241 (2004) 1-12
16. Berger E.A., et al. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17 (1999) 657-700
17. Benkirane M., et al. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by CCR5Δ32. J. Biol. Chem. 272 (1997) 30603-30606
18. Libert F., et al. The Δccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. Hum. Mol. Genet. 7 (1998) 399-406
19. O'Brien S.J., and Nelson G.W. Human genes that limit AIDS. Nat. Genet. 36 (2004) 565-574
20. Przeworski M. The signature of positive selection at randomly chosen loci. Genetics 160 (2002) 1179-1189
21. Bersaglieri T., et al. Genetic signatures of strong recent positive selection at the lactase gene. Am. J. Hum. Genet. 74 (2004) 1111-1120
22. Myers S., et al. A fine-scale map of recombination rates and hotspots across the human genome. Science 310 (2005) 321-324
23. Kreitman M., and Hudson R.R. Inferring the evolutionary histories of the Adh and Adh-dup loci in Drosophila melanogaster from patterns of polymorphism and divergence. Genetics 127 (1991) 565-582
24. Begun D.J., et al. Is the fast/slow allozyme variation at the Adh locus of Drosophila melanogaster an ancient balanced polymorphism?. Mol. Biol. Evol. 16 (1999) 1816-1819