Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart

Journal of Immunology

Volumn 176, Issue 11, 2006, Pages 6568-6575

  Cai, Yi Hong ^a   Alvarez, Angeles ^a   Alcaide, Pilar ^a   Duramad, Paurene ^a   Lim, Yaw Chin ^b   Jarolim, Petr ^a   Lowe, John B ^c   Luscinskas, Francis W ^a   Lichtman, Andrew H ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; ALPHA 1,3 FUCOSYLTRANSFERASE; ANTIGEN; CD8 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; LIGAND; OVALBUMIN; PADGEM PROTEIN; SELECTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CARDIAC GRAFT REJECTION; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL SPECIFICITY; CONTROLLED STUDY; DISEASE SEVERITY; HEART MUSCLE INJURY; IN VITRO STUDY; MOUSE; MYOCARDITIS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

EID: 33646885328     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.11.6568     Document Type: Article

References (32)

1. Binah, O. 2002. Cytotoxic lymphocytes and cardiac electrophysiology. J. Mol. Cell. Cardiol. 34: 1147-1161.
2. Ley, K., and G. S. Kansas. 2004. Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat. Rev. Immunol. 4: 325-335.
3. Knibbs, R. N., R. A. Craig, P. Maĺy, P. L. Smith, F. M. Wolber, N. E. Faulkner, J. B. Lowe, and L. M. Stoolman. 1998. α(1,3)- Fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts. J. Immunol. 161: 6305-6315.
4. Smithson, G., C. E. Rogers, P. L. Smith, E. P. Scheidegger, B. Petryniak, J. T. Myers, D. S. L. Kim, J. W. Homeister, and J. B. Lowe. 2001. Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes. J. Exp. Med. 194: 601-614.
5. + T cell effectors that cause myocarditis. J. Clin. Invest. 111: 671-680.
6. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
7. Carbone, F. R., and M. J. Bevan. 1989. Induction of ovalbumin-specinc cytotoxic T cells by in vivo peptide immunization. J. Exp. Med. 169: 603-612.
8. Homeister, J. W., A. D. Thall, B. Petryniak, P. Maĺy, C. E. Rogers, P. L. Smith, R. J. Kelly, K. M. Gersten, S. W. Askari, G. Cheng, et al. 2001. The α(1,3)fucosyl-transferases FucT-IV and FucT-IV exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 15: 115-126.
9. + T cell responses in the heart. Am. J. Pathol. 163: 2413-2420.
10. Buono, C., C. E. Come, G. Stavrakis, G. F. Maguire, P. W. Connelly, and A. H. Lichtman. 2003. Influence of interferon-γ on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 23: 454-460.
11. + T cell core 2 β-1,6-N-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J. Immunol. 167: 4476-4484.
12. Lim, Y. C., L. Henault, A. J. Wagers, G. S. Kansas, F. W. Luscinskas, and A. H. Lichtman. 1999. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J. Immunol. 162: 3193-3201.
13. Nolte, M. A., A. Hamann, G. Kraal, and R. E. Mebius. 2002. The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors. Immunology 106: 299-307.
14. + T cell migration into the skin, but normal extravasation into visceral organs. J. Immunol. 168: 2139-2146.
15. Lefer, A. M. 1995. Role of selectins in myocardial ischemia-reperfusion injury. Ann. Thorac. Surg. 60: 773-777.
16. Wang, Y., M. Afanasyeva, S. L. Hill, and N. R. Rose. 1999. Characterization of murine autoimmune myocarditis induced by self and foreign cardiac myosin. Autoimmunity 31: 151-162.
17. Lácha, J., A. Bushell, K. Smetana, P. Rossmann, P. Pøibylová, K. Wood, and P. Malý. 2002. Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse models. J. Leukocyte Biol. 71: 311-318.
18. Renkonen, R., M. N. Fukuda, L. Petrov, T. Paavonen, J. Renkonen, P. Hayry, and M. Fukuda. 2002. A peptide mimic of selectin ligands abolishes in vivo inflammation but has no effect on the rat heart allograft survival 1. Transplantation 74: 2-6.
19. Austrup, F., D. Vestweber, E. Borges, M. Löhning, R. Brauer, U. Herz, H. Renz, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 385: 81-83.
20. Bullard, D., E. Kunkel, H. Kubo, M. Hicks, I. Lorenzo, N. Doyle, C. Doerschuk, K. Ley, and A. Beaudet. 1996. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 183: 2329-2336.
21. Frenette, P. S., T. N. Mayadas, H. Rayburn, R. O. Hynes, and D. D. Wagner. 1996. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 84: 563-574.
22. + T lymphocytes into inflamed skin. J. Immunol. 169: 4307-4313.
23. Staite, N., J. Justen, L. Sly, A. Beaudet, and D. Bullard. 1996. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood 88: 2973-2979.
24. Subramaniam, M., S. Saflaripour, S. Watson, T. Mayadas, R. Hynes, and D. Wagner. 1995. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. J. Exp. Med. 181: 2277-2282.
25. + T cells migrate into inflamed skin only if they express ligands for E- and P-selectin. J. Immunol. 161: 963-970.
26. + T cells. J. Exp. Med. 189: 1765-1776.
27. Engelhardt, B., D. Vestweber, R. Hallmann, and M. Schulz. 1997. E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis. Blood 90: 4459-4472.
28. + T lymphocytes to sites of viral infection does not require endothelial selectins. Blood 95: 1362-1369.
29. Taqueti, V., R. N. Mitchell, and A. H. Lichtman. 2006. Protecting the pump: controlling myocardial inflammatory responses. Annu. Rev. Physiol. 68: 67-95.
30. Chong, B. F., J.-E. Murphy, T. S. Kupper, and R. C. Fuhlbrigge. 2004. E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. J. Immunol. 172: 1575-1581.
31. Maksymowicz, M., B. Lukomska, A. Ziolkowska, S. Janczewska, E. Cybulska, and W. L. Olszewski. 1998. Cyclosporin A decreases lymphocyte migration to the heart allograft through suppression of their L-selectin expression. Ann. Transplant. 3: 34-36.
32. Toppila, S., T. Paavonen, M. S. Nieminen, P. Hayry, and R. Renkonen. 1999. Endothelial L-selectin ligands are likely to recruit lymphocytes into rejecting human heart transplants. Am. J. Pathol. 155: 1303-1310.