Requirement of ELC1 for RNA polymerase II polyubiquitylation and degradation in response to DNA damage in Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 26, Issue 11, 2006, Pages 3999-4005

  Ribar, Balazs ^a   Prakash, Louise ^a   Prakash, Satya ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ELC1 PROTEIN; FUNGAL DNA; FUNGAL PROTEIN; GENE PRODUCT; NONTRANSCRIBED DNA; PROTEASOME; PROTEIN; RAD16 PROTEIN; RAD23 PROTEIN; RAD7 PROTEIN; RNA POLYMERASE II; RPB1 PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; DNA DAMAGE; DNA REPAIR; ELC1 GENE; ENZYME SUBUNIT; EXCISION REPAIR; FUNGAL GENE; GENOME; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RNA DEGRADATION; RNA METABOLISM; SACCHAROMYCES CEREVISIAE; UBIQUITINATION; ULTRAVIOLET RADIATION;

DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; EPISTASIS, GENETIC; GENES, FUNGAL; LYSINE; MUTATION; POLYUBIQUITIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS;

SACCHAROMYCES CEREVISIAE;

EID: 33646883307     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00293-06     Document Type: Article

References (39)

1. Alani, E., L. Cao, and N. Kleckner. 1987. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted genes. Genetics 116:541-545.
2. Aso, T., and M. N. Conrad. 1997. Molecular cloning of DNAs encoding the regulatory subunits of elongin from Saccahromyces cerevisiae and Drosophila melanogaster. Biochem. Biophys. Res. Commun. 241:334-340.
3. Aso, T., W. S. Lane, J.W. Conaway, and R. C. Conaway. 1995. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Science 269: 1439-1443.
4. Beaudenon, S. L., M. R. Huacani, G. Wang, D. P. McDonnell, and J. M. Huibregtse. 1999. Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:6972-6979.
5. Bradsher, J. N., K. W. Jackson, R. C. Conaway, and J. W. Conaway. 1993. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. J. Biol. Chem. 268:25587-25593.
6. Bradsher, J. N., S. Tan, H. J. McLaury, J. W. Conaway, and R. C. Conaway. 1993. RNA polymerase II transcription factor SIII. II. Functional properties and role in RNA chain elongation. J. Biol. Chem. 268:25594-25603.
7. Bregman, D. B., R. Halaban, A. J. van Gool, K. A. Henning, E. C. Friedberg, and S. L. Warren. 1996. UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells. Proc. Natl. Acad. Sci. USA 93:11586-11590.
8. Duan, D. R., A. Pause, W. H. Burgess, T. Aso, D. Y. Chen, K. P. Garrett, R. C. Conaway, J. W. Conaway, W. M. Linehan, and R. D. Klausner. 1995. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269:1402-1406.
9. Guzder, S. N., V. Bailly, P. Sung, L. Prakash, and S. Prakash. 1995. Yeast DNA repair protein RAD23 promotes complex formation between transcription factor TF11H and DNA damage recognition factor RAD14. J. Biol. Chem. 270:8385-8388.
10. Guzder, S. N., Y. Habraken, P. Sung, L. Prakash, and S. Prakash. 1995. Reconstitution of yeast nucleotide excision repair with purified Rad proteins, replication protein A, and transcription factor TF11H. J. Biol. Chem. 270: 12973-12976.
11. Guzder, S. N., P. Sung, L. Prakash, and S. Prakash. 1998. Affinity of yeast nucleotide excision repair factor 2, consisting of the Rad4 and Rad23 proteins, for ultraviolet damaged DNA. J. Biol. Chem. 273:31541-31546.
12. Guzder, S. N., P. Sung, L. Prakash, and S. Prakash. 1998. The DNA-dependent ATPase activity of yeast nuclcotide excision repair factor 4 and its role in DNA damage recognition. J. Biol. Chem. 273:6292-6296.
13. Guzder, S. N., P. Sung, L. Prakash, and S. Prakash. 1997. Yeast Rad7-Radl6 complex specific for the nucleotide excision repair of the nontranscribed DNA strand, is an ATP-dependent DNA damage sensor. J. Biol. Chem. 272:21665-21668.
14. Hochstrasser, M., M. J. Ellison, V. Chau, and A. Varshavsky. 1991. The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo. Proc. Natl. Acad. Sci. USA 88:4606-4610.
15. Jansen, L. E. T., R. A. Verhage, and J. Brouwer. 1998. Preferential binding of yeast Rad4-Rad23 complex to damaged DNA. J. Biol. Chem. 273:33111-33114.
16. Kamura, T., D. M. Koepp, M. N. Conrad, D. Skowyra, R. J. Moreland, O. Iliopoulos, W. S. Lane, W. G. J. Kaelin, S. J. Elledge, R. C. Conaway, J. W. Harper, and J. W. Conaway. 1999. Rbx1, a component of the VHL tumor suppressor comples and SCF ubiquitin ligase. Science 284:657-661.
17. Kamura, T., S. Sato, K. Iwai, M. F. Czyzyk-Krzeska, R. C. Conaway, and J. W. Conaway. 2000. Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA 97:10430-10435.
18. Kibel, A., O. Iliopoulos, J. A. DeCaprio, and W. G. J. Kaelin. 1995. Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C. Science 269:1444-1446.
19. Kishida, T., T. M. Stackhouse, F. Chen, M. I. Lerman, and B. Zbar. 1995. Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer Res. 55:4544-4548.
20. Krsmanovic, T., and R. Rolling. 2004. The HECT E3 ubiquitin ligase Rsp5 is important for ubiquitin homeostasis in yeast. FEBS Lett. 577:215-219.
21. Li, S., and M. J. Smerdon. 2002. Rpb4 and Rpb9 mediate subpathways of transcription-coupled DNA repair in Saccharomyces cerevisiae. EMBO J. 21:5921-5929.
22. Lonergan, K. M., O. Iliopoulos, M. Ohh, T. Kamura, R. C. Conaway, J. W. Conaway, and W. G. J. Kaelin. 1998. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongs B/C and Cul2. Mol. Cell. Biol. 18:732-741.
23. Mellon, I., and P. C. Hanawalt. 1989. Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature 342:95-98.
24. Mellon, I., G. Spivak, and P. C. Hanawalt. 1987. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell 51:241-249.
25. Ortolan, T. G., L. Chen, P. Tongaonkar, and K. Madura. 2004. Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway. Nucleic Acids Res. 32:6490-6500.
26. Pause, A., S. Lee, R. A. Worrell, D. Y. Chen, W. H. Burgess, W. M. Linehan, and R. D. Klausner. 1997. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl. Acad. Sci. USA 94:2156-2161.
27. Prakash, S., and L. Prakash. 2000. Nucleotide excision repair in yeast. Mutat. Res. 451:13-24.
28. Ramsey, K. L., J. J. Smith, A. Dasgupta, N. Maqani, P. Grant, and D. T. Auble. 2004. The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair. Mol. Cell. Biol. 24:6362-6378.
29. Ratner, J. N., B. Balasubramanian, J. Corden, S. L. Warren, and D. B. Bregman. 1998. Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. J. Biol. Chem. 273: 5184-5189.
30. Russell, S. J., S. H. Reed, W. Huang, E. C. Friedberg, and S. A. Johnston. 1999. The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair. Mol. Cell 3:687-695.
31. Sancar, A. 1996. DNA excision repair. Annu. Rev. Biochem. 65:43-81.
32. Schauber, C., L. Chen, P. Tongaonkar, I. Vego, D. Lambertson, W. Potts, and K. Madura. 1998. Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature 391:715-718.
33. Smerdon, M., and F. Thoma. 1990. Site-specific DNA repair at the nucleosome level in a yeast minichromosome. Cell 61:675-684.
34. van Hoffen, A., A. T. Natarajan, L. V. Mayne, A. A. van Zeeland, L. H. F. Mullenders, and J. Venema. 1993. Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. Nucleic Acids Res. 21:5890-5895.
35. Venema, J., L. H. F. Mullenders, A. T. Natarajan, A. A. van Zeeland, and L. V. Mayne. 1990. The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. Proc. Natl. Acad. Sci. USA 87:4707-4711.
36. Verhage, R., A.-M. Zeeman, N. de Groot, F. Gleig, D. D. Gang, P. van de Putte, and J. Brouwer. 1994. The RAD7 and RAD16 genes, which are essential for pyrimidine dimer removal from the silent mating type loci, are also required for repair of the nontranscribed strand of an active gene in Saccharomyces cerevisiae. Mol. Cell. Biol. 14:6135-6142.
37. Verhage, R. A., A. J. van Gool, N. de Groot, J. H. J. Hoeijmakers, P. van de Putte, and J. Brouwer. 1996. Double mutants of Saccharomyces cerevisiae with alterations in global genome and transcription-coupled repair. Mol. Cell. Biol. 16:496-502.
38. Watkins, J. F., P. Sung, L. Prakash, and S. Prakash. 1993. The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function. Mol. Cell. Biol. 13:7757-7765.
39. Woudsra, E. C., C. Gilbert, J. Fellows, L. Jansen, J. Brouwer, H. Erdjument-Bromage, P. Tempst, and J. Q. Svejstrup. 2002. A Rad26-Dcf1 complex coordinates repair and RNA II proteolysis in response to DNA damage. Nature 415:929-933.