In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

European Journal of Pharmaceutical Sciences

Volumn 28, Issue 4, 2006, Pages 325-335

  Andersen, Rikke ^a   Nielsen, Carsten Uhd ^a   Begtrup, Mikael ^a   Jørgensen, Flemming Steen ^a   Brodin, Birger ^a   Frokjaer, Sven ^a   Steffansen, Bente ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

hPEPT1; N methyl amide isostere; PEPT1; Transepithelial transport; Tripeptides; Tripeptidomimetics

Indexed keywords

N METHYLAMIDE TRIPEPTIDOMIMETIC DERIVATIVE; PEPTIDE TRANSPORTER 1; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMIDES; CACO-2 CELLS; DRUG DESIGN; DRUG STABILITY; HUMANS; INTESTINAL MUCOSA; KINETICS; METHYLATION; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDE HYDROLASES; PRINCIPAL COMPONENT ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 33646853318     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.03.007     Document Type: Article

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