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Volumn 19, Issue 2, 2006, Pages 145-150

Effects of antipsychotics on brain structure

Author keywords

Antipsychotics; Basal ganglia; Brain structure; Magnetic resonance imaging

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RISPERIDONE; ZIPRASIDONE;

EID: 33646828012     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.yco.0000214339.06507.d8     Document Type: Review
Times cited : (182)

References (36)
  • 3
    • 0031932403 scopus 로고    scopus 로고
    • Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies
    • Lawrie SM, Abukmeil SS. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 1998; 172:110-120.
    • (1998) Br J Psychiatry , vol.172 , pp. 110-120
    • Lawrie, S.M.1    Abukmeil, S.S.2
  • 4
    • 0030798020 scopus 로고    scopus 로고
    • Schizophrenia as a chronic active brain process: A study of progressive brain structural change subsequent to the onset of schizophrenia
    • DeLisi LE, Sakuma M, Tew W, et al. Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Res 1997; 74:129-140.
    • (1997) Psychiatry Res , vol.74 , pp. 129-140
    • DeLisi, L.E.1    Sakuma, M.2    Tew, W.3
  • 5
    • 0035869532 scopus 로고    scopus 로고
    • Longitudinal study of brain morphology in first episode schizophrenia
    • Lieberman J, Chakos M, Wu H, et al. Longitudinal study of brain morphology in first episode schizophrenia. Biol Psychiatry 2001; 49:487-499.
    • (2001) Biol Psychiatry , vol.49 , pp. 487-499
    • Lieberman, J.1    Chakos, M.2    Wu, H.3
  • 6
    • 0037977109 scopus 로고    scopus 로고
    • Progressive structural brain abnormalities and their relationship to clinical outcome: A longitudinal magnetic resonance imaging study early in schizophrenia
    • Ho BC, Andreasen NC, Nopoulos P, et al. Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Arch Gen Psychiatry 2003; 60:585-594.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 585-594
    • Ho, B.C.1    Andreasen, N.C.2    Nopoulos, P.3
  • 7
    • 0031734725 scopus 로고    scopus 로고
    • Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism
    • Woods BT. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry 1998; 155:1661-1670.
    • (1998) Am J Psychiatry , vol.155 , pp. 1661-1670
    • Woods, B.T.1
  • 8
    • 0032719083 scopus 로고    scopus 로고
    • The neuropathological effects of antipsychotic drugs
    • Harrison PJ. The neuropathological effects of antipsychotic drugs. Schizophr Res 1999; 40:87-99.
    • (1999) Schizophr Res , vol.40 , pp. 87-99
    • Harrison, P.J.1
  • 9
    • 0035890854 scopus 로고    scopus 로고
    • Antipsychotic drugs and neuroplasticity: Insights into the treatment and neurobiology of schizophrenia
    • Konradi C, Heckers S. Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia. Biol Psychiatry 2001; 50:729-742.
    • (2001) Biol Psychiatry , vol.50 , pp. 729-742
    • Konradi, C.1    Heckers, S.2
  • 10
    • 15244341948 scopus 로고    scopus 로고
    • Changes in brain structure caused by neuroleptic medication
    • Scherk H, Falkai P. Changes in brain structure caused by neuroleptic medication. Nervenarzt 2004; 75:1112-1117.
    • (2004) Nervenarzt , vol.75 , pp. 1112-1117
    • Scherk, H.1    Falkai, P.2
  • 11
    • 0028125229 scopus 로고
    • Cerebral morphometry and clozapine treatment in schizophrenia
    • Bilder RM, Wu H, Chakos MH, et al. Cerebral morphometry and clozapine treatment in schizophrenia. J Clin Psychiatry 1994; 55 (Suppl B):53-56.
    • (1994) J Clin Psychiatry , vol.55 , Issue.SUPPL. B , pp. 53-56
    • Bilder, R.M.1    Wu, H.2    Chakos, M.H.3
  • 12
    • 0031763361 scopus 로고    scopus 로고
    • Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia
    • Gur RE, Maany V, Mozley PD, et al. Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Am J Psychiatry 1998; 155:1711-1717.
    • (1998) Am J Psychiatry , vol.155 , pp. 1711-1717
    • Gur, R.E.1    Maany, V.2    Mozley, P.D.3
  • 13
    • 13444256341 scopus 로고    scopus 로고
    • Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure
    • Pressler M, Nopoulos P, Ho BC, Andreasen NC. Insular cortex abnormalities in schizophrenia: relationship to symptoms and typical neuroleptic exposure. Biol Psychiatry 2005; 57:394-398. This is the first study examining the effect of antipsychotic treatment on insular cortex.
    • (2005) Biol Psychiatry , vol.57 , pp. 394-398
    • Pressler, M.1    Nopoulos, P.2    Ho, B.C.3    Andreasen, N.C.4
  • 14
    • 20144365633 scopus 로고    scopus 로고
    • Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: The AESOP study
    • Dazzan P, Morgan KD, Orr K, et al. Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the AESOP study. Neuropsychopharmacology 2005; 30:765-774. In this study, the increased thalamic volume was positively associated with dose of olanzapine.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 765-774
    • Dazzan, P.1    Morgan, K.D.2    Orr, K.3
  • 15
    • 0035070250 scopus 로고    scopus 로고
    • Effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia
    • Scheepers FE, Gispen de Wied CC, Hulshoff Pol HE, Kahn RS. Effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia. Am J Psychiatry 2001; 158:644-646.
    • (2001) Am J Psychiatry , vol.158 , pp. 644-646
    • Scheepers, F.E.1    Gispen De Wied, C.C.2    Hulshoff Pol, H.E.3    Kahn, R.S.4
  • 16
    • 0344500596 scopus 로고    scopus 로고
    • Change in basal ganglia volume over 2 years in patients with schizophrenia: Typical versus atypical neuroleptics
    • Corson PW, Nopoulos P, Miller DD, et al. Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics. Am J Psychiatry 1999; 156:1200-1204.
    • (1999) Am J Psychiatry , vol.156 , pp. 1200-1204
    • Corson, P.W.1    Nopoulos, P.2    Miller, D.D.3
  • 17
    • 4744338973 scopus 로고    scopus 로고
    • Reduced basal ganglia volumes after switching to olanzapine in chronically treated patients with schizophrenia
    • Lang DJ, Kopala LC, Vandorpe RA, et al. Reduced basal ganglia volumes after switching to olanzapine in chronically treated patients with schizophrenia. Am J Psychiatry 2004; 161:1829-1836.
    • (2004) Am J Psychiatry , vol.161 , pp. 1829-1836
    • Lang, D.J.1    Kopala, L.C.2    Vandorpe, R.A.3
  • 18
    • 20144389942 scopus 로고    scopus 로고
    • Antipsychotic drug effects on brain morphology in first-episode psychosis
    • Lieberman JA, Tollefson GD, Charles C, et al. Antipsychotic drug effects on brain morphology in first-episode psychosis. Arch Gen Psychiatry 2005; 62:361-370. Owing to a large number of subjects and long-term examination, this is a very important study. Treatment with haloperidol lead to a decrease in grey matter volume and an increase in caudate volume.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 361-370
    • Lieberman, J.A.1    Tollefson, G.D.2    Charles, C.3
  • 19
    • 0028141509 scopus 로고
    • Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs
    • Chakos MH, Lieberman JA, Bilder RM, et al. Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. Am J Psychiatry 1994; 151:1430-1436.
    • (1994) Am J Psychiatry , vol.151 , pp. 1430-1436
    • Chakos, M.H.1    Lieberman, J.A.2    Bilder, R.M.3
  • 20
    • 0028104623 scopus 로고
    • Changes in caudate volume with neuroleptic treatment
    • Keshavan MS, Bagwell WW, Haas GL, et al. Changes in caudate volume with neuroleptic treatment. Lancet 1994; 344:1434.
    • (1994) Lancet , vol.344 , pp. 1434
    • Keshavan, M.S.1    Bagwell, W.W.2    Haas, G.L.3
  • 21
    • 0035070369 scopus 로고    scopus 로고
    • An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone
    • Lang DJ, Kopala LC, Vandorpe RA, et al. An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone. Am J Psychiatry 2001; 158:625-631.
    • (2001) Am J Psychiatry , vol.158 , pp. 625-631
    • Lang, D.J.1    Kopala, L.C.2    Vandorpe, R.A.3
  • 22
    • 0347416821 scopus 로고    scopus 로고
    • Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent
    • Heitmiller DR, Nopoulos PC, Andreasen NC. Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent. Schizophr Res 2004; 66:137-142.
    • (2004) Schizophr Res , vol.66 , pp. 137-142
    • Heitmiller, D.R.1    Nopoulos, P.C.2    Andreasen, N.C.3
  • 23
    • 20144379785 scopus 로고    scopus 로고
    • Volume changes in gray matter in first-episode neuroleptic-naive schizophrenic patients treated with risperidone
    • Massana G, Salgado-Pineda P, Junque C, et al. Volume changes in gray matter in first-episode neuroleptic-naive schizophrenic patients treated with risperidone. J Clin Psychopharmacol 2005; 25:111-117. In contrast to other findings, these authors observed an increased grey matter volume of caudate after exposition to risperidone.
    • (2005) J Clin Psychopharmacol , vol.25 , pp. 111-117
    • Massana, G.1    Salgado-Pineda, P.2    Junque, C.3
  • 24
    • 15544368726 scopus 로고    scopus 로고
    • Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosis
    • Tauscher-Wisniewski S, Tauscher J, Christensen BK, et al. Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosis. J Psychiatr Res 2005; 39:365-370. These authors could not observe effects of quetiapine on brain structure in neuroleptic-naïve patients.
    • (2005) J Psychiatr Res , vol.39 , pp. 365-370
    • Tauscher-Wisniewski, S.1    Tauscher, J.2    Christensen, B.K.3
  • 25
    • 21344436172 scopus 로고    scopus 로고
    • Cerebral cortical gray expansion associated with two second-generation antipsychotics
    • Garver DL, Holcomb JA, Christensen JD. Cerebral cortical gray expansion associated with two second-generation antipsychotics. Biol Psychiatry 2005; 58:62-66. This VBM examination revealed increased cortical grey matter volume following atypical but not typical treatment.
    • (2005) Biol Psychiatry , vol.58 , pp. 62-66
    • Garver, D.L.1    Holcomb, J.A.2    Christensen, J.D.3
  • 26
    • 0036277310 scopus 로고    scopus 로고
    • Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: What is happening in the schizophrenic brain?
    • Weinberger DR, McClure RK. Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain? Arch Gen Psychiatry 2002; 59:553-558.
    • (2002) Arch Gen Psychiatry , vol.59 , pp. 553-558
    • Weinberger, D.R.1    McClure, R.K.2
  • 27
    • 0030776430 scopus 로고    scopus 로고
    • Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography
    • Miller DD, Andreasen NC, O'Leary DS, et al. Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography. Neuropsychopharmacology 1997; 17:230-240.
    • (1997) Neuropsychopharmacology , vol.17 , pp. 230-240
    • Miller, D.D.1    Andreasen, N.C.2    O'Leary, D.S.3
  • 28
    • 18744420100 scopus 로고    scopus 로고
    • Striatal enlargement in rats chronically treated with neuroleptic
    • Chakos MH, Shirakawa O, Lieberman J, et al. Striatal enlargement in rats chronically treated with neuroleptic. Biol Psychiatry 1998; 44:675-684.
    • (1998) Biol Psychiatry , vol.44 , pp. 675-684
    • Chakos, M.H.1    Shirakawa, O.2    Lieberman, J.3
  • 29
    • 0021988597 scopus 로고
    • The effects of haloperidol on synaptic patterns in the rat striatum
    • Benes FM, Paskevich PA, Davidson J, Domesick VB. The effects of haloperidol on synaptic patterns in the rat striatum. Brain Res 1985; 329:265-273.
    • (1985) Brain Res , vol.329 , pp. 265-273
    • Benes, F.M.1    Paskevich, P.A.2    Davidson, J.3    Domesick, V.B.4
  • 30
    • 9644281929 scopus 로고    scopus 로고
    • Etiopathogenetic mechanisms in long-term course of schizophrenia
    • Falkai P, Tepest R, Schulze TG, et al. Etiopathogenetic mechanisms in long-term course of schizophrenia. Pharmacopsychiatry 2004; 37 (Suppl 2):S136-S140.
    • (2004) Pharmacopsychiatry , vol.37 , Issue.2 SUPPL.
    • Falkai, P.1    Tepest, R.2    Schulze, T.G.3
  • 31
    • 18044365379 scopus 로고    scopus 로고
    • Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: Role of 5-HT1A receptor activation
    • Cosi C, Waget A, Rollet K, et al. Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation. Brain Res 2005; 1043:32-41.
    • (2005) Brain Res , vol.1043 , pp. 32-41
    • Cosi, C.1    Waget, A.2    Rollet, K.3
  • 32
    • 17744399498 scopus 로고    scopus 로고
    • N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: Novel insights and clinical perspectives
    • Berl
    • Millan MJ. N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives. Psychopharmacology (Berl) 2005; 179:30-53.
    • (2005) Psychopharmacology , vol.179 , pp. 30-53
    • Millan, M.J.1
  • 33
    • 4644252709 scopus 로고    scopus 로고
    • Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801
    • Fumagalli F, Molteni R, Bedogni F, et al. Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. Neuroreport 2004; 15:2109-2112.
    • (2004) Neuroreport , vol.15 , pp. 2109-2112
    • Fumagalli, F.1    Molteni, R.2    Bedogni, F.3
  • 34
    • 16844363642 scopus 로고    scopus 로고
    • Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain
    • Angelucci F, Aloe L, Iannitelli A, et al. Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain. Eur Neuropsychopharmacol 2005; 15:311-317.
    • (2005) Eur Neuropsychopharmacol , vol.15 , pp. 311-317
    • Angelucci, F.1    Aloe, L.2    Iannitelli, A.3
  • 35
    • 2442691413 scopus 로고    scopus 로고
    • Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus
    • Halim ND, Weickert CS, McClintock BW, et al. Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus. Neuropsychopharmacology 2004; 29:1063-1069.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1063-1069
    • Halim, N.D.1    Weickert, C.S.2    McClintock, B.W.3
  • 36
    • 2942679455 scopus 로고    scopus 로고
    • Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat
    • Wang HD, Dunnavant FD, Jarman T, Deutch AY. Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat. Neuropsychopharmacology 2004; 29:1230-1238.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1230-1238
    • Wang, H.D.1    Dunnavant, F.D.2    Jarman, T.3    Deutch, A.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.