Molecular basis for the cellular senescence program and its application to anticancer therapy

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 5, 2006, Pages 1076-1081

  Katakura, Yoshinori ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Oxidative stress; Senescence; Telomerase; TGF

Indexed keywords

CHEMOTHERAPY; ENZYMES; GROWTH KINETICS; MOLECULAR DYNAMICS; ONCOLOGY; PATIENT TREATMENT;

OXIDATIVE STRESS; SENESCENCE; TELOMERASE; TGF-Β;

CELLS;

TELOMERASE; TRANSFORMING GROWTH FACTOR BETA;

CELL AGING; GENETICS; HUMAN; LUNG TUMOR; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; REVIEW; TELOMERE; TUMOR SUPPRESSOR GENE;

CELL AGING; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG NEOPLASMS; OXIDATIVE STRESS; TELOMERASE; TELOMERE; TRANSFORMING GROWTH FACTOR BETA;

EID: 33646819354     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.70.1076     Document Type: Review

References (26)

1. Hayflick, L., The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res., 37, 614-636 (1965).
2. Harley, C. B., Telomere loss: mitotic clock or genetic time bomb? Mutat. Res., 256, 271-282 (1991).
3. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O., Peacocke, M., and Campisi, J., A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA, 92, 9363-9367 (1995).
4. Chen, Q., and Ames, B. N., Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci. USA, 91, 4130-4134 (1994).
5. Campisi, J., Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell, 120, 513-522 (2005).
6. Katakura, Y., Nakata, E., Miura, T., and Shirahata, S., Transforming growth factor β triggers two independent-senescence programs in cancer cells. Biochem. Biophys. Res. Commun., 255, 110-115 (1999).
7. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W., Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88, 593-602 (1997).
8. Sugrue, M. M., Shin, D. Y., Lee, S. W., and Aaronson, S. A., Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Natl. Acad. Sci. USA, 94, 9648-9653 (1997).
9. Xu, H.-J., Zhou, Y., Ji, W., Perng, G.-S., Kruzelock, R., Kong, C.-T., Bast, R. C., Mills, G. B., Li, J., and Hu, S.-X., Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene, 15, 2589-2596 (1997).
10. Iwasa, H., Han, J., and Ishikawa, F., Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells, 8, 131-144 (2003).
11. Wang, W., Chen, J. X., Liao, R., Deng, Q., Zhou, J. J., Huang, S., and Sun, P., Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol. Cell. Biol., 22, 3389-3403 (2002).
12. 2 stress triggers a release of transforming growth factor-β1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem., 276, 2531-2537 (2001).
13. Lin, H. K., Bergmann, S., and Pandolfi, P. P., Cytoplasmic PML function in TGF-β signalling. Nature, 431, 205-211 (2004).
14. Roninson, I. B., Tumor cell senescence in cancer treatment. Cancer Res., 63, 2705-2715 (2003).
15. Katakura, Y., Nakata, E., Tabira, Y., Miura, T., Teruya, K., Tsuchiya, T., and Shirahata, S., Decreased tumorigenicity in vivo when transforming growth factor β treatment causes cancer cell senescence. Biosci. Biotechnol. Biochem., 67, 815-821 (2003).
16. Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H., Schlegelberger, B., Stein, H., Dorken, B., Jenuwein, T., and Schmitt, C. A., Oncogene-induced senescence as an initial barrier in lymphoma development. Nature, 436, 660-665 (2005).
17. Chen, Z., Trotman, L. C., Shaffer, D., Lin, H. K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., Cordon-Cardo, C., and Pandolfi, P. P., Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature, 436, 725-730 (2005).
18. Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguria, A., Zaballos, A., Flores, J. M., Barbacid, M., Beach, D., and Serrano, M., Tumour biology: senescence in premalignant tumours. Nature, 436, 642 (2005).
19. Michaloglou, C., Vredeveld, L. C., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M., Majoor, D. M., Shay, J. W., Mooi, W. J., and Peeper, D. S., BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature, 436, 720-724 (2005).
20. Kawamoto, S., Inoue, Y., Shinozaki, Y., Katakura, Y., Tachibana, H., Shirahata, S., and Murakami, H., Impaired tumor phenotypes in class II major histocompatibility complex antigen-inducible cells originated from human lung adenocarcinoma. Biochem. Biophys. Res. Commun., 215, 280-285 (1995).
21. Katakura, Y., Yamamoto, K., Miyake, O., Yasuda, T., Uehara, N., Nakata, E., Kawamoto, S., and Shirahata, S., Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma. Biochem. Biophys. Res. Commun., 237, 313-317 (1997).
22. Katakura, Y., Yoshizaki, K., Yasuda, T., Tsunematsu, T., Uehara, N., Miura, T., Fujiki, T., and Shirahata, S., Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. Biochem. Biophys. Res. Commun., 334, 450-459 (2005).
23. Uehara, N., Katakura, Y., Miura, T., and Shirahata, S., Subtractive screening of genes involved in cellular senescence. Cytotechnol., 35, 35-42 (2001).
24. Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly, Y. M., Gidlof, S., Oldfors, A., Wibom, R., Tornell, J., Jacobs, H. T., and Larsson, N. G., Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature, 429, 417-423 (2004).
25. 2: senescence-like growth arrest or apoptosis? Cell Growth Differ., 8, 589-598 (1997).
26. 2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem. J., 332, 43-50 (1998).