Differential role of cyclooxygenase 1 and 2 isoforms in the modulation of colonic neuromuscular function in experimental inflammation

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 3, 2006, Pages 938-945

  Fornai, Matteo ^a   Blandizzi, Corrado ^a   Antonioli, Luca ^a   Colucci, Rocchina ^a   Bernardini, Nunzia ^a   Segnani, Cristina ^a   De Ponti, Fabrizio ^b   Del Tacca, Mario ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROBENZENESULFONIC ACID; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 5,5 DIMETHYL 3 (3 FLUOROPHENYL) 4 (4 METHYLSULFONYL)PHENYL 2 (5H) FURANONE; ATROPINE; CARBACHOL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FURANONE DERIVATIVE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; S METHYLPSEUDOTHIOUREA; SULFONIC ACID DERIVATIVE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MOTILITY; COLITIS; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; GANGLION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICAL ASSESSMENT; MUSCLE CONTRACTION; NEUROMUSCULAR FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; COLITIS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DISEASE MODELS, ANIMAL; GASTROINTESTINAL MOTILITY; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYENTERIC PLEXUS; NEUROMUSCULAR JUNCTION; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33646814993     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.098350     Document Type: Article

References (28)

1. Afulukwe IF, Cohen RI, Zeballos GA, Iqbal M, and Scharf SM (2000) Selective NOS inhibition restores myocardial contractility in endotoxemic rats: however, myocardial NO content does not correlate with myocardial dysfunction. Am J Respir Crit Care Med 162:21-26.
2. Barbara G, Xing Z, Hogaboam CM, Gauldie J, and Collins SM (2000) Interleukin 10 gene transfer prevents experimental colitis in rats. Gut 46:344-349.
3. Bernardini N, Bianchi F, and Dolfi A (1999) Laminin and beta1 integrin distribution in the early stages of human kidney development. Nephron 81:289-295.
4. 2- adrenoceptors in the presence of experimental colitis. Br J Pharmacol 139:309-320.
5. Collins SM (1996) The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 111:1683-1699.
6. Costa M (2004) COX and the gut: now we see it now we don't. Neurogastroenterol Motil 16:693-695.
7. De Backer O, Leclere PG, and Lefebvre RA (2003) Pharmacological characterization of pre- and postsynaptic prostanoid receptors in pig gastric fundus. Neuropharmacology 45:684-690.
8. Dijkstra G, Moshage H, Van Dullemen HM, De Jager-Krikken A, Tiebosch ATMG, Kleibeuker JH, Jansen PLM, and Van Goor H (1998) Expression of nitric oxide synthase and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease. J Pathol 186:416-421.
9. Fornai M, Blandizzi C, Colucci R, Antonioli L, Bernardini N, Segnani C, Baragatti B, Barogi S, Berti P, Spisni R, et al. (2005a) Role of cyclooxygenase 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice. Gut 54:608-616.
10. Fornai M, Natale G, Colucci R, Tuccori M, Carazzina G, Antonioli L, Baldi S, Lubrano V, Abramo A, Blandizzi C, et al. (2005b) Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage. Naunyn- Schmiedeberg's Arch Pharmacol 372:79-87.
11. Fujimoto Y, Uno E, and Sakuma S (2004) Effects of reactive oxygen and nitrogen species on cyclooxygenase-1 and -2 activities. Prostaglandins Leukotrienes Essent Fatty Acids 71:335-340.
12. Kato M, Nishida S, Kitasato H, Sakata N, and Kawai S (2001) Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol 53:1679-1685.
13. Linden DR, Sharkey KA, Ho W, and Mawe GM (2004) Cyclooxygenase-2 contributes to dysmotility and enhance excitability of myenteric AH neurones in the inflamed guinea pig distal colon. J Physiol (Lond) 557:191-205.
14. Maihofner C, Tegeder I, Euchenhofer C, Dewitt D, Brune K, Bang R, Neuhuber W, and Geisslinger G (2000) Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord. Neuroscience 101:1093-1108.
15. 2 in guinea pig colonic myenteric ganglia. Am J Physiol 283:G1388-G1397.
16. Oz HS, Chen TS, McClain CJ, and de Villiers WJS (2005) Antioxidants as novel therapy in a murine model of colitis. J Nutr Biochem 16:297-304.
17. Porcher C, Horowitz B, Bayguinov O, Ward SM, and Sanders KM (2002) Constitutive expression and function of cyclooxygenase-2 in murine gastric muscle. Gastroenterology 122:1442-1454.
18. Porcher C, Horowitz B, Ward SM, and Sanders KM (2004) Constitutive expression and functional expression of cyclooxygenase 2 in the murine proximal colon. Neurogastroenterol Motil 16:785-799.
19. Riendeau D, Percival MD, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Falgueyret JP, Ford-Hutchinson AW, et al. (1997) Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol 121:105-117.
20. Roberts PJ, Morgan K, Miller R, Hunter JO, and Middleton SJ (2001) Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease. Gut 48:468-472.
21. Schwarz NT, Kalff JC, Turler A, Engel BM, Watkins SC, Billiar TR, and Bauer AG (2001) Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology 121:1354-1371.
22. Segui J, Gironella M, Sans M, Granell S, Gil F, Gimeno M, Coronel P, Pique JM, and Panes J (2004) Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression and leukocyte recruitment into the inflamed intestine. J Leukoc Biol 76:537-544.
23. Sharkey KA and Kroese ABA (2001) Consequences of intestinal inflammation on the enteric nervous system: neuronal activation induced by inflammatory mediators. Anat Rec 262:79-90.
24. Subbaramaiah K and Dannenberg AJ (2003) Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci 24:96-102.
25. Takeuchi T, Okuda M, and Yagasaki O (1991) The differential contribution of endogenous prostaglandins to the release of acetylcholine from the myenteric plexus of the guinea-pig ileum. Br J Pharmacol 102:381-385.
26. Tanaka A, Hase S, Miyazawa T, and Takeuchi K (2002) Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage. J Pharmacol Exp Ther 300:754-761.
27. Wallace JL and Devchand PR (2005) Emerging roles for cyclooxygenase-2 in gastrointestinal mucosa defense. Br J Pharmacol 145:275-282.
28. Wallace JL and Keenan CM (1990) An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis. Am J Physiol 258:G527-G534.