Can 29 kDa rhGM-CSF expressed by Silkworm pupae bioreactor bring into effect as active cytokine through orally administration?

European Journal of Pharmaceutical Sciences

Volumn 28, Issue 3, 2006, Pages 212-223

  Zhang, Yaozhou ^a   Chen, Jian ^a   Lv, Zhengbing ^a   Nie, Zuoming ^a   Zhang, Xiaoyan ^a   Wu, Xiangfu ^a,b  

^a ZHEJIANG SCI TECH UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Absorbable effect; BmNPV; Bombyx mori pupae; Expression; Oral administration; rhGM CSF

Indexed keywords

CYCLOPHOSPHAMIDE; GLYCOPROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IODINE 125; PROTEIN ANTIBODY; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BIOLOGICAL ACTIVITY; BIOREACTOR; BLOOD SAMPLING; BONE MARROW CELL; COLONY FORMATION; CONTROLLED STUDY; DEGLYCOSYLATION; DNA SYNTHESIS; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GAMMA RADIATION; HISTIOCYTE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INSECT; INTESTINE BRUSH BORDER; ISOTOPE LABELING; LEUKOCYTE COUNT; LEUKOPENIA; MACACA; MOUSE; MYOBLAST; NEUTROPHIL; NONHUMAN; PEPTIDE MAPPING; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYHEDROSIS VIRUS; PRIORITY JOURNAL; PROMYELOCYTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SILKWORM; SPLEEN; VIRUS RECOMBINANT; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; BLOOD; CELL CULTURE; CHEMISTRY; CLONOGENIC ASSAY; DISEASE MODEL; GENETICS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; INTESTINE; INTESTINE ABSORPTION; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; BIOREACTORS; BOMBYX; BONE MARROW CELLS; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTORS, RECOMBINANT; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HISTIOCYTES; HUMANS; INTESTINAL ABSORPTION; INTESTINES; LEUKOCYTE COUNT; LEUKOPENIA; MACACA; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PUPA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33646765803     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.02.014     Document Type: Article

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