NicVAX™: Aid to smoking cessation nicotine vaccine

Drugs of the Future

Volumn 31, Issue 3, 2006, Pages 203-205

  Boyd, B ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DOPAMINE; DRUG ANTIBODY; NEUROTRANSMITTER; NICOTINE; NICOTINE DERIVATIVE; NICOTINE VACCINE; SODIUM CHLORIDE; TOBACCO SMOKE; UNCLASSIFIED DRUG; VACCINE;

CIGARETTE SMOKING; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; NONHUMAN; PASSIVE IMMUNIZATION; REVIEW; SEIZURE; SMOKING CESSATION; SMOKING HABIT; TOBACCO; VACCINATION; WORLD HEALTH ORGANIZATION;

EID: 33646758232     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2006.031.03.975527     Document Type: Review

References (17)

1. Prous Science Drug R&D Backgrounders: Nicotine Addiction (online publication). Updated February 13, 2006.
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3. NicVAX completes phase II dose-ranging study, set for proof-of-concept trial. DailyDrugNews.com (Daily Essentials) January 30, 2006.
4. NicVAX awarded fast track designation. DailyDrugNews.com (Daily Essentials) March 13, 2006.
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11. Pentel, P.R., Malin, D.H., Ennifar, S. et al. A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats. Pharmacol Biochem Behav 2000, 65: 191-8.
12. Malin, D.H., Alvarado, C.L., Woodhouse, K.S. et al. Passive immunization against nicotine attenuates nicotine discrimination. Life Sci 2002, 70: 2793-8.
13. Malin, D.H., Lake, J.R., Lin, A. et al. Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome. Pharmacol Biochem Behav 2001, 68: 87-92.
14. NicVAX nicotine vaccine completes preclinical safety testing. DailyDrugNews.com (Daily Essentials) November 20, 2001.
15. Preliminary phase I results for NicVAX. DailyDrugNews.com (Daily Essentials) October 9, 2002.
16. Positive phase I/II results for NicVax. DailyDrugNews.com (Daily Essentials) March 4, 2004.
17. Hatsukami, D.K., Rennard, S., Jorenby, D., Fiore, M., Koopmeiners, J., de Vos, A., Horwith, G., Pentel, P.R. Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin Pharmacol Ther 2005, 78: 456-67.