Infarct-remodeled myocardium is receptive to protection by isoflurane postconditioning: Role of protein kinase B/Akt signaling

Anesthesiology

Volumn 104, Issue 5, 2006, Pages 1004-1014

  Feng, Jianhua ^a,b   Fischer, Gregor ^b   Lucchinetti, Eliana ^a,b   Zhu, Min ^a,b   Bestmann, Lukas ^c   Jegger, David ^d   Arras, Margarete ^b   Pasch, Thomas ^a   Perriard, Jean Claude ^e   Schaub, Marcus C ^b   Zaugg, Michael ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; ISOFLURANE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; S6 KINASE; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG ANTAGONISM; ENZYME PHOSPHORYLATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; HEART VENTRICLE REMODELING; IMMUNOHISTOCHEMISTRY; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANESTHETICS, INHALATION; ANIMALS; BLOTTING, WESTERN; CARDIOTONIC AGENTS; HEMODYNAMIC PROCESSES; ISOFLURANE; MALE; MYOCARDIUM; ONCOGENE PROTEIN V-AKT; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; VENTRICULAR REMODELING;

EID: 33646756156     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200605000-00017     Document Type: Article

References (49)

1. Mann DL: Mechanisms and models in heart failure: A combinatorial approach. Circulation 1999; 100:999-1008
2. Wilson EM, Diwan A, Spinale FG, Mann DL: Duality of innate stress responses in cardiac injury, repair, and remodeling. J Mol Cell Cardiol 2004; 37:801-11
3. Neubauer S, Horn M, Naumann A, Tian R, Hu K, Laser M, Friedrich J, Gaudron P, Schnackerz K, Ingwall JS, Ertl G: Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest 1995; 95:1092-100
4. Yang XM, Proctor JB, Cui L, Krieg T, Downey JM, Cohen MV: Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol 2004; 44:1103-10
5. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM: Postconditioning: A form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 2004; 95:230-2
6. Chiari PC, Bienengraeber MW, Pagel PS, Krolikowski JG, Kersten JR, Warltier DC: Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: Evidence for anesthetic-induced postconditioning in rabbits. ANESTHESIOLOGY 2005; 102:102-9
7. Feng J, Lucchinetti E, Ahuja P, Pasch T, Perriard JC, Zaugg M: Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3β. ANESTHESIOLOGY 2005; 103:987-95
8. Weihrauch D, Krolikowski JG, Bienengraeber M, Kersten JR, Warltier DC, Pagel PS: Morphine enhances isoflurane-induced postconditioning against myocardial infarction: The role of phosphatidylinositol-3-kinase and opioid receptors in rabbits. Anesth Analg 2005; 101:942-9
9. Perrault LP, Menasche P, Bel A, de Chaumaray T, Peynet J, Mondry A, Olivero P, Emanoil-Ravier R, Moalic JM: Ischemic preconditioning in cardiac surgery: A word of caution. J Thorac Cardiovasc Surg 1996; 112:1378-86
10. Malkowski MJ, Kramer CM, Parvizi ST, Dianzumba S, Marquez J, Reichek N, Magovern JA: Transient ischemia does not limit subsequent ischemic regional dysfunction in humans: A transesophageal echocardiographic study during minimally invasive coronary artery bypass surgery. J Am Coll Cardiol 1998; 31:1035-9
11. Ghosh S, Standen NB, Galinianes M: Failure to precondition pathological human myocardium. J Am Coll Cardiol 2001; 37:711-8
12. Hausenloy DJ, Tsang A, Mocanu MM, Yellon DM: Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol 2005; 288:H971-6
13. Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner RA, Braunwald E: Myocardial infarct size and ventricular function in rats. Circ Res 1979; 44:503-12
14. Gupta S, Prahash AJ, Anand IS: Myocyte contractile function is intact in the post-infarct remodeled rat heart despite molecular alterations. Cardiovasc Res 2000; 48:77-88
15. Uecker M, da Silva R, Grampp T, Pasch T, Schaub MC, Zaugg M: Translocation of protein kinase C isoforms to subcellular targets in ischemic and anesthetic preconditioning. ANESTHESIOLOGY 2003; 99:138-47
16. Rothermel BA, Berenji K, Tannous P, Kutschke W, Dey A, Nolan B, Yoo KD, Demetroulis E, Gimbel M, Cabuay B, Karimi M, Hill JA: Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure. Physiol Genomics 2005; 23:18-27
17. Miyamoto T, Takeishi Y, Takahashi H, Shishido T, Arimoto T, Tomoike H, Kubota I: Activation of distinct signal transduction pathways in hypertrophied hearts by pressure and volume overload. Basic Res Cardiol 2004; 99:328-37
18. Kacimi R, Gerdes AM: Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure. Hypertension 2003; 41:968-77
19. Jamnicki-Abegg M, Weihrauch D, Pagel PS, Kersten JR, Bosnjak ZJ, Warltier DC, Bienengraeber MW: Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. ANESTHESIOLOGY 2005; 103:1006-14
20. Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 2003; 285:H579-88
21. Vinten-Johansen J, Yellon DM, Opie LH: Postconditioning: A simple, clinically applicable procedure to improve revascularization in acute myocardial infarction. Circulation 2005; 112:2085-8
22. Warltier DC, al-Wathiqui MH, Kampine JP, Schmeling WT: Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane. ANESTHESIOLOGY 1988; 69:552-65
23. Vinten-Johansen J, Zhao ZQ, Zatta AJ, Kin H, Halkos ME, Kerendi F: Postconditioning: A new link in nature's armor against myocardial ischemia-reperfusion injury. Basic Res Cardiol 2005; 100:295-310
24. Yang XM, Philipp S, Downey JM, Cohen MV: Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation. Basic Res Cardiol 2005; 100:57-63
25. Murry CE, Jennings RB, Reimer KA: Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74:1124-36
26. Obal D, Scharbatke H, Barthel H, Preckel B, Mullenheim J, Schlack W: Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats. Can J Anaesth 2003; 50:940-5
27. Lucchinetti E, da Silva R, Pasch T, Schaub MC, Zaugg M: Anaesthetic preconditioning but not postconditioning prevents early activation of the deleterious cardiac remodelling programme: Evidence of opposing genomic responses in cardioprotection by pre- and postconditioning. Br J Anaesth 2005; 95:140-52
28. Schaper J, Froede R, Hein S, Buck A, Hashizume H, Speiser B, Friedl A, Bleese N: Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 1991; 83:504-14
29. Ehler E, Perriard JC: Cardiomyocyte cytoskeleton and myofibrillogenesis in healthy and diseased heart. Heart Fail Rev 2000; 5:259-69
30. Litwin SE, Litwin CM, Raya TE, Warner AL, Goldman S: Contractility and stiffness of noninfarcted myocardium after coronary ligation in rats: Effects of chronic angiotensin converting enzyme inhibition. Circulation 1991; 83:1028-37
31. Solomon SD, Anavekar NS, Greaves S, Rouleau JL, Hennekens C, Pfeffer MA: Angina pectoris prior to myocardial infarction protects against subsequent left ventricular remodeling. J Am Coll Cardiol 2004; 43:1511-4
32. Konstam MA: Reliability of ventricular remodeling as a surrogate for use in conjunction with clinical outcomes in heart failure. Am J Cardiol 2005; 96:867-71
33. Miki T, Miura T, Tsuchida A, Nakano A, Hasegawa T, Fukuma T, Shimamoto K: Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation. Circulation 2000; 102:458-63
34. Miki T, Miura T, Tanno M, Sakamoto J, Kuno A, Genda S, Matsumoto T, Ichikawa Y, Shimamoto K: Interruption of signal transduction between G protein and PKC-epsilon underlies the impaired myocardial response to ischemic preconditioning in postinfarct remodeled hearts. Mol Cell Biochem 2003; 247:185-93
35. Kehl F, Krolikowski JG, Weihrauch D, Pagel PS, Warltier DC, Kersten JR: N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. ANESTHESIOLOGY 2003; 98:1384-90
36. Sniecinski R, Liu H: Reduced efficacy of volatile anesthetic preconditioning with advanced age in isolated rat myocardium. ANESTHESIOLOGY 2004; 100:589-97
37. Zaugg M, Lucchinetti E, Garcia C, Pasch T, Spahn DR, Schaub MC: Anaesthetics and cardiac preconditioning: II. Clinical implications. Br J Anaesth 2003; 91:566-76
38. Hausenloy DJ, Tsang A, Yellon DM: The reperfusion injury salvage kinase pathway: A common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc Med 2005; 15:69-75
39. da Silva R, Grampp T, Pasch T, Schaub MC, Zaugg M: Differential activation of mitogen-activated protein kinases in ischemic and anesthetic preconditioning. ANESTHESIOLOGY 2004; 100:59-69
40. Darling CE, Jiang R, Maynard M, Whittaker P, Vinten-Johansen J, Przyklenk K: Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: Role of ERK1/2. Am J Physiol Heart Circ Physiol 2005; 289:H1618-26
41. Yang XM, Krieg T, Cui L, Downey JM, Cohen MV: NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. J Mol Cell Cardiol 2004; 36:411-21
42. ATP channels via multiple signaling pathways. ANESTHESIOLOGY 2002; 97:4-14
43. Obal D, Dettwiler S, Favoccia C, Scharbatke H, Preckel B, Schlack W: The influence of mitochondrial KATP-channels in the cardioprotection of preconditioning and postconditioning by sevoflurane in the rat in vivo. Anesth Analg 2005; 101:1252-60
44. Piriou V, Chiari P, Gateau-Roesch O, Argaud L, Muntean D, Salles D, Loufouat J, Gueugniaud PY, Lehot JJ, Ovize M: Desflurane-induced preconditioning alters calcium-induced mitochondrial permeability transition. ANESTHESIOLOGY 2004; 100:581-8
45. Julier K, da Silva R, Garcia C, Bestmann L, Frascarolo P, Zollinger A, Chassot PG, Schmid ER, Turina MI, von Segesser LK, Pasch T, Spahn DR, Zaugg M: Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: A double-blinded, placebo-controlled, multicenter study. ANESTHESIOLOGY 2003; 98:1315-27
46. Garcia C, Julier K, Bestmann L, Zollinger A, von Segesser LK, Pasch T, Spahn DR, Zaugg M: Preconditioning with sevoflurane decreases PECAM-1 expression and improves one-year cardiovascular outcome in coronary artery bypass graft surgery. Br J Anaesth 2005; 94:159-65
47. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit JF, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M: Postconditioning the human heart. Circulation 2005; 112:2143-8
48. De Hert SG, Van der Linden PJ, Cromheecke S, Meeus R, Nelis A, Van Reeth V, ten Broecke PW, De Blier IG, Stockman BA, Rodrigus IE: Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. ANESTHESIOLOGY 2004; 101:299-310
49. Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P: Mitochondrial PKCe and MAPK form signaling modules in the murine heart: Enhanced mitochondrial PKCε-MAPK interactions and differential MAPK activation in PKCε-induced cardioprotection. Circ Res 2002; 90:390-7