TrkA expression is associated with an elevated level of apoptosis in classic medulloblastomas

Neuropathology

Volumn 26, Issue 3, 2006, Pages 170-177

  Ohta, Takashi ^a   Watanabe, Takao ^a   Katayama, Yoichi ^a   Kurihara, Jun ^b   Yoshino, Atsuo ^a   Nishimoto, Hiroshi ^b   Kishimoto, Hiroshi ^b  

^a NIHON UNIVERSITY   (Japan)

^b SAITAMA CHILDREN'S MEDICAL CENTER   (Japan)

Author keywords

Apoptosis; Medulloblastoma; Neurotrophin; Prognosis; TrkA

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN S 100; PROTEIN TYROSINE KINASE A; SYNAPTOPHYSIN;

ADOLESCENT; APOPTOSIS; ARTICLE; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MEDULLOBLASTOMA; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; PROGNOSIS;

ADOLESCENT; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFANT; KI-67 ANTIGEN; MALE; MEDULLOBLASTOMA; PROGNOSIS; RECEPTOR, TRKA; RECEPTOR, TRKC; S100 PROTEINS; SURVIVAL ANALYSIS; SURVIVAL RATE; SYNAPTOPHYSIN; TUMOR MARKERS, BIOLOGICAL;

EID: 33646734858     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2006.00678.x     Document Type: Article

References (28)

1. Giangaspero F, Bigner SH, Kleihues P, Pietsch T, Trojanowski JQ. Medulloblastomas. In: Kleihues P, Cavenee WK (eds) Pathology, and Genetics of Tumours of the Nervous System: World Health Organization International Classification of Tumours. Lyon, France: International Agency for Research on Cancer, 2000 129 137.
2. Giordana MT, Schiffer P, Schiffer D. Prognostic factors in medulloblastoma. Childs Nerv Syst 1998 14: 256 262.
3. Zelter PM, Boyett JM, Finlay JL et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 1999 17: 832 845.
4. Jenkin D, Shabanah MA, Shail EA et al. Prognostic factors for medulloblastoma. Int J Radiat Oncol Biol Phys 2000 47: 573 584.
5. Silber JH, Radcliffe J, Peckham V et al. Whole-brain irradiation and decline in intelligence: the influence of dose and age on IQ score. J Clin Oncol 1992 10: 1390 1396.
6. Ris MD, Packer R, Goldwein J, Janes-Wallace D, Boyett JM. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a children's cancer group study. J Clin Oncol 2001 19: 3470 3476.
7. Ellison D. Classifying the medulloblastoma: insights from morphology and molecular genetics. Neuropathol Appl Neurobiol 2002 28: 257 282.
8. Woodburn RT, Azzarelli B, Montebello JF, Goss IE. Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. J Neuro-Oncol 2001 52: 57 62.
9. Giangaspero F, Perilongo G, Fondelli MP et al. Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neurosurg 1999 91: 971 977.
10. Barbacid M. Neurotrophic factors and their receptors. Curr Opin Cell Biol 1995 7: 148 155.
11. Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001 24: 677 736.
12. Nakagawa A, Arima-Nakagawara M, Scavarda NJ, Azar CG, Cantor AB, Brodeur GM. Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N Engl J Med 1993 328: 847 854.
13. Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL. Expression of the neurotorophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci USA 1994 91: 12867 12871.
14. Kim JYH, Sutton ME, Lu DJ et al. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res 1999 59: 711 719.
15. Grotzer MA, Janss AJ, Fung K-M et al. TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors. J Clin Oncol 2000 18: 1027 1035.
16. Haslam RHA, Lamborn KR, Becker LE, Israel MA. Tumor cell apoptosis present at diagnosis may predict treatment outcome for patients with medulloblastoma. J Pediatr Hematol Oncol 1998 20: 520 527.
17. Korshunov A, Savostikova M, Ozerov S. Immunohistochemical markers for prognosis of average-risk pediatric medulloblastomas: the effect of apoptotic index, TrkC, and c-myc expression. J Neuro-Oncol 2002 58: 271 279.
18. Muragaki Y, Chou TT, Kaplan DR, Trojanowski JQ, Lee VMY. Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors. J Neurosci 1997 17: 530 542.
19. Chou TT, Trojanowski JQ, Lee VMY. A novel apoptotic pathway induced by nerve growth factor-mediated TrkA activation in medulloblastoma. J Biol Chem 2000 275: 565 570.
20. Grotzer MA, Janss AJ, Fung KM et al. Abundance of apoptotic neoplastic cells in diagnostic biopsy samples is not a prognostic factor in childhood primitive neuroectodermal tumors of the central nervous system. J Pediatr Hematol Oncol 2001 23: 25 29.
21. Ray A, Ho M, Ma J et al. A clinicobiological model predicting survival in medulloblastoma. Clin Cancer Res 2004 10: 7613 7620.
22. Pizem J, Cör A, Zaletel LZ, Popovic M. Prognostic significance of apoptosis in medulloblastoma. Neurosci Lett 2005 381: 69 73.
23. Gajjar A, Hernan R, Kocak M et al. Clinical, histopathologic, and molecular markers of prognosis: towards a new disease risk stratification system for medulloblastoma. J Clin Oncol 2004 22: 984 993.
24. Eberhart CG, Kratz J, Wang Y et al. Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia. J Neuropathol Exp Neurol 2004 63: 441 449.
25. Washiyama K, Muragaki Y, Rorke LB et al. Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system. Am J Pathol 1996 148: 929 940.
26. Tajima Y, Molina RP Rorke LB et al. Neurotrophins and neuronal versus glial differentiation in medulloblastomas and other pediatric brain tumors. Acta Neuropathol 1998 95: 325 332.
27. Eberhart CG, Kaufman WE, Tihan T, Burger PC. Apoptosis, neuronal maturation, and neurotrophin expression within medulloblastoma nodules. J Neuropathol Exp Neurol 2001 60: 462 469.
28. Chiappa SA, Chin LS, Zurawel RH, Raffel C. Neurotrophin and Trk receptors in primitive neuroectodermal tumor cell lines. Neurosurgery 1999 45: 1148 1155.