-
1
-
-
0018322135
-
The metabolism of tamoxifen in humans
-
Adam, H. K., Douglas, E. J., Kemp, J. V. (1979). The metabolism of tamoxifen in humans. Biochem. Pharmacol. 27:145-147.
-
(1979)
Biochem. Pharmacol.
, vol.27
, pp. 145-147
-
-
Adam, H.K.1
Douglas, E.J.2
Kemp, J.V.3
-
2
-
-
0019132163
-
Evidence for the metabolic activation of non-steroidal antioestrogens: A study of structure-activity relationships
-
Allen, K. E., Clark, E. R., Jordan, V. C. (1980). Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships. Br J. Pharmacol 71:83-91.
-
(1980)
Br. J. Pharmacol.
, vol.71
, pp. 83-91
-
-
Allen, K.E.1
Clark, E.R.2
Jordan, V.C.3
-
3
-
-
0242526030
-
Distinct molecular conformations of the estrogen receptor alpha complex exploited by environmental estrogens
-
Bentrem, D., Fox, J. E., Pearce, S. T., Liu, H., Pappas, S., Kupfer, D., Zapf, J. W., Jordan, V. C. (2003). Distinct molecular conformations of the estrogen receptor alpha complex exploited by environmental estrogens. Cancer Res. 63:7490-7496.
-
(2003)
Cancer Res.
, vol.63
, pp. 7490-7496
-
-
Bentrem, D.1
Fox, J.E.2
Pearce, S.T.3
Liu, H.4
Pappas, S.5
Kupfer, D.6
Zapf, J.W.7
Jordan, V.C.8
-
4
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski, A. M., Pike, A. C., Dauter, Z., Hubbard, R. E., Bonn, T., Engstrom, O., Ohman, L., Greene, G. L., Gustaffson, J. A., Carlquist, M. (1997). Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389:753-758.
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
Hubbard, R.E.4
Bonn, T.5
Engstrom, O.6
Ohman, L.7
Greene, G.L.8
Gustaffson, J.A.9
Carlquist, M.10
-
5
-
-
0021987828
-
Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants
-
Bulger, W. H., Feil, V. J., Kupfer, D. (1985). Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants. Mol. Pharmacol. 27:115-124.
-
(1985)
Mol. Pharmacol.
, vol.27
, pp. 115-124
-
-
Bulger, W.H.1
Feil, V.J.2
Kupfer, D.3
-
6
-
-
0018099018
-
Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. I. Comparison with estradiol-17 beta activity
-
Bulger, W. H., Kupfer, D. (1978). Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. I. Comparison with estradiol-17 beta activity. Pest. Biochem. Physiol. 8:253-262.
-
(1978)
Pest. Biochem. Physiol.
, vol.8
, pp. 253-262
-
-
Bulger, W.H.1
Kupfer, D.2
-
7
-
-
0020964670
-
Estrogenic action of DDT analogs
-
Bulger, W. H., Kupfer, D. (1983). Estrogenic action of DDT analogs. Am. J. Ind. Med. 4:163-173.
-
(1983)
Am. J. Ind. Med.
, vol.4
, pp. 163-173
-
-
Bulger, W.H.1
Kupfer, D.2
-
8
-
-
0018015306
-
Interactions of chlorinated hydrocarbon pesticides with the 8S estrogen-binding protein in rat testes
-
Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978a). Interactions of chlorinated hydrocarbon pesticides with the 8S estrogen-binding protein in rat testes. Steroids 32.
-
(1978)
Steroids
, vol.32
-
-
Bulger, W.H.1
Muccitelli, R.M.2
Kupfer, D.3
-
9
-
-
0018009080
-
Interactions of methoxychlor, methoxychlor base-soluble contaminant, and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane with rat uterine estrogen receptor
-
Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978b). Interactions of methoxychlor, methoxychlor base-soluble contaminant, and 2,2-bis(p- hydroxyphenyl)-1,1,1-trichloroethane with rat uterine estrogen receptor. J. Toxicol. Environ. Health 4:881-893.
-
(1978)
J. Toxicol. Environ. Health
, vol.4
, pp. 881-893
-
-
Bulger, W.H.1
Muccitelli, R.M.2
Kupfer, D.3
-
10
-
-
0018078757
-
Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites: Role of hepatic mono-oxygenase in methoxychlor activation
-
Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978c). Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites: role of hepatic mono-oxygenase in methoxychlor activation. Biochem. Pharmacol. 27:2417-2423.
-
(1978)
Biochem. Pharmacol.
, vol.27
, pp. 2417-2423
-
-
Bulger, W.H.1
Muccitelli, R.M.2
Kupfer, D.3
-
11
-
-
0018102530
-
Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. II. Kinetic characteristics of omithine decarboxylase induced by DDT analogs and estradiol
-
Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978d). Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. II. Kinetic characteristics of omithine decarboxylase induced by DDT analogs and estradiol. Pest. Biochem. Physiol. 27:263-270.
-
(1978)
Pest. Biochem. Physiol.
, vol.27
, pp. 263-270
-
-
Bulger, W.H.1
Muccitelli, R.M.2
Kupfer, D.3
-
12
-
-
0020645907
-
Covalent binding of [14C]methoxychlor metabolite(s) to rat liver microsomal components
-
Bulger, W. H., Temple, J. E., Kupfer, D. (1983). Covalent binding of [14C]methoxychlor metabolite(s) to rat liver microsomal components. Toxicol. Appl. Pharmacol. 68:367-374.
-
(1983)
Toxicol. Appl. Pharmacol.
, vol.68
, pp. 367-374
-
-
Bulger, W.H.1
Temple, J.E.2
Kupfer, D.3
-
13
-
-
0015069359
-
A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI 46474
-
Cole, M. P., Jones, C. T., Todd, I. D. (1971). A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI 46474. Br. J. Cancer. 25:270-275.
-
(1971)
Br. J. Cancer.
, vol.25
, pp. 270-275
-
-
Cole, M.P.1
Jones, C.T.2
Todd, I.D.3
-
14
-
-
51149188436
-
Synthetic oestrogenic agents without the phenanthrene nucleus
-
Dodds, E. C., Lawson, W. (1936). Synthetic oestrogenic agents without the phenanthrene nucleus. Nature 137:996.
-
(1936)
Nature
, vol.137
, pp. 996
-
-
Dodds, E.C.1
Lawson, W.2
-
15
-
-
0024269590
-
Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women
-
EBCTCG. (1988). Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women. N. Engl. J. Med. 319:1681-1692.
-
(1988)
N. Engl. J. Med.
, vol.319
, pp. 1681-1692
-
-
-
16
-
-
0015748908
-
The metabolism of tamoxifen (ICI 46,474) Part II in femal patients
-
Fromson, J. M., Pearson, S., Bramah, S. (1973). The metabolism of tamoxifen (ICI 46,474) Part II in femal patients. Xenobiotica 3:711-713.
-
(1973)
Xenobiotica
, vol.3
, pp. 711-713
-
-
Fromson, J.M.1
Pearson, S.2
Bramah, S.3
-
17
-
-
0027201501
-
Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
-
Greaves, P., Goonetilleke, R., Nunn, G., Topham, J., Orton, T. (1993). Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res. 53:3919-3924.
-
(1993)
Cancer Res.
, vol.53
, pp. 3919-3924
-
-
Greaves, P.1
Goonetilleke, R.2
Nunn, G.3
Topham, J.4
Orton, T.5
-
18
-
-
0026606580
-
Induction of covalent DNA adducts in rodents by tamoxifen
-
Han, X. L., Liehr, J. G. (1992). Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Res. 52:1360-1363.
-
(1992)
Cancer Res.
, vol.52
, pp. 1360-1363
-
-
Han, X.L.1
Liehr, J.G.2
-
19
-
-
0027428568
-
Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Cr1:CD(BR) rats
-
Hard, G. C., Iatropoulos, M. J., Jordan, K., Radi, L., Kaltenberg, O. P., Imondi, A. R., Williams, G. M. (1993). Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Cr1:CD(BR) rats. Cancer Res. 53:4534-4541.
-
(1993)
Cancer Res.
, vol.53
, pp. 4534-4541
-
-
Hard, G.C.1
Iatropoulos, M.J.2
Jordan, K.3
Radi, L.4
Kaltenberg, O.P.5
Imondi, A.R.6
Williams, G.M.7
-
20
-
-
0014039539
-
Mode of action of I.C.I. 46,474 in preventing implantation in rats
-
Harper, M. J., Walpole, A. L. (1967a). Mode of action of I.C.I. 46,474 in preventing implantation in rats. J. Endocrinol. 37:83-92.
-
(1967)
J. Endocrinol.
, vol.37
, pp. 83-92
-
-
Harper, M.J.1
Walpole, A.L.2
-
21
-
-
0014053604
-
A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
-
Harper, M. J., Walpole, A. L. (1967b). A new derivative of triphenylethylene: effect on implantation and mode of action in rats. J. Reprod. Fertil. 13:101-119.
-
(1967)
J. Reprod. Fertil.
, vol.13
, pp. 101-119
-
-
Harper, M.J.1
Walpole, A.L.2
-
23
-
-
0016592723
-
Detection of the 8 S oestrogen-binding component in human uterine endometrium during the menstrual cycle
-
Hunter, R. E., Jordan, V. C. (1975). Detection of the 8 S oestrogen-binding component in human uterine endometrium during the menstrual cycle. J. Endocrinol. 65:457-458.
-
(1975)
J. Endocrinol.
, vol.65
, pp. 457-458
-
-
Hunter, R.E.1
Jordan, V.C.2
-
24
-
-
0018893540
-
Stimulaation of uterine deoxyribonucleic acid synthesis by 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane (o, p'DDT)
-
Ireland, J. S., Mukku, V. R., Robison, A. K., Stancel, G. M. (1980). Stimulaation of uterine deoxyribonucleic acid synthesis by 1,1,1-trichloro-2-(p- chlorophenyl)-2-(o-chlorophenyl)ethane (o, p'DDT). Biochem. Pharmacol. 29:1469-1474.
-
(1980)
Biochem. Pharmacol.
, vol.29
, pp. 1469-1474
-
-
Ireland, J.S.1
Mukku, V.R.2
Robison, A.K.3
Stancel, G.M.4
-
25
-
-
0015171224
-
Estrogen receptors and breast cancer response to adrenalectomy
-
Jensen, E. V., Block, G. E., Smith, K., DeSombre, E. R. (1971). Estrogen receptors and breast cancer response to adrenalectomy. Natl. Cancer Inst. Monogr. 34:55-70.
-
(1971)
Natl. Cancer Inst. Monogr.
, vol.34
, pp. 55-70
-
-
Jensen, E.V.1
Block, G.E.2
Smith, K.3
DeSombre, E.R.4
-
26
-
-
0001464486
-
Basic guides to the mechanism of estrogen action
-
Jensen, E. V., Jacobson, H. I. (1962). Basic guides to the mechanism of estrogen action. Recent Progr. Hormone Res. 18:387-414.
-
(1962)
Recent Progr. Hormone Res.
, vol.18
, pp. 387-414
-
-
Jensen, E.V.1
Jacobson, H.I.2
-
27
-
-
0026520381
-
Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor
-
Jiang, S. Y., Jordan, V. C. (1992). Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J. Natl. Cancer Inst. 84:580-591.
-
(1992)
J. Natl. Cancer Inst.
, vol.84
, pp. 580-591
-
-
Jiang, S.Y.1
Jordan, V.C.2
-
28
-
-
0016424339
-
Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse
-
Jordan, V. C. (1975). Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse. J. Reprod. Fertil. 42:251-258.
-
(1975)
J. Reprod. Fertil.
, vol.42
, pp. 251-258
-
-
Jordan, V.C.1
-
29
-
-
0037364074
-
Tamoxifen: A most unlikely pioneering medicine
-
Jordan, V. C. (2003a). Tamoxifen: a most unlikely pioneering medicine. Nature Reviews Drug Discovery 2:205-213.
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, pp. 205-213
-
-
Jordan, V.C.1
-
30
-
-
0037621719
-
Antiestrogens and selective estrogen receptor modulators as multifunctional medicines Part II: Clinical Considerations and New Agents
-
Jordan, V. C. (2003b). Antiestrogens and selective estrogen receptor modulators as multifunctional medicines Part II: Clinical Considerations and New Agents. J. Med. Chem. 46:1082-1111.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1082-1111
-
-
Jordan, V.C.1
-
31
-
-
0017665570
-
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
-
Jordan, V. C., Collins, M. M., Rowsby, L., Prestwich, G. (1977). A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J. Endocrinol. 75:305-316.
-
(1977)
J. Endocrinol.
, vol.75
, pp. 305-316
-
-
Jordan, V.C.1
Collins, M.M.2
Rowsby, L.3
Prestwich, G.4
-
32
-
-
0016425439
-
Inhibition of oestradiol binding to mouse uterine and vaginal oestrogen receptors by triphenylethylenes
-
Jordan, V. C., Koerner, S. (1975a). Inhibition of oestradiol binding to mouse uterine and vaginal oestrogen receptors by triphenylethylenes. J. Endocrinol. 64:193-194.
-
(1975)
J. Endocrinol.
, vol.64
, pp. 193-194
-
-
Jordan, V.C.1
Koerner, S.2
-
33
-
-
0016638259
-
Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor
-
Jordan, V. C., Koerner, S. (1975b). Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor. Eur. J. Cancer 11:205-206.
-
(1975)
Eur. J. Cancer
, vol.11
, pp. 205-206
-
-
Jordan, V.C.1
Koerner, S.2
-
34
-
-
0035884114
-
Molecular classification of estrogens
-
Jordan, V. C., Schafer, J. M., Levenson, A. S., Liu, H., Pease, K. M., Simons, L. A., Zapf, J. W. (2001). Molecular classification of estrogens. Cancer Res. 61:6619-6623.
-
(2001)
Cancer Res.
, vol.61
, pp. 6619-6623
-
-
Jordan, V.C.1
Schafer, J.M.2
Levenson, A.S.3
Liu, H.4
Pease, K.M.5
Simons, L.A.6
Zapf, J.W.7
-
35
-
-
0025220695
-
Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrane treated rats
-
Juedes, M. J., Kupfer, D. (1990). Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrane treated rats. Drug Metab. Dispos. 18:131-137.
-
(1990)
Drug Metab. Dispos.
, vol.18
, pp. 131-137
-
-
Juedes, M.J.1
Kupfer, D.2
-
36
-
-
0013829730
-
Hormone therapy for advanced breast cancer
-
Kennedy, B. J. (1965). Hormone therapy for advanced breast cancer. Cancer 18:1551-1557.
-
(1965)
Cancer
, vol.18
, pp. 1551-1557
-
-
Kennedy, B.J.1
-
37
-
-
0016562704
-
Effects of pesticides and related compounds on steroid metabolism and function
-
Kupfer, D. (1975). Effects of pesticides and related compounds on steroid metabolism and function. CRC Crit. Rev. Toxicol. 4:83-124.
-
(1975)
CRC Crit. Rev. Toxicol.
, vol.4
, pp. 83-124
-
-
Kupfer, D.1
-
38
-
-
0017028095
-
Interactions of chlorinated hydrocarbons with steroid hormones
-
Kupfer, D. (1976). Interactions of chlorinated hydrocarbons with steroid hormones. Fed. Proc. 35:2603-2608.
-
(1976)
Fed. Proc.
, vol.35
, pp. 2603-2608
-
-
Kupfer, D.1
-
39
-
-
0017059441
-
Studies on the mechanism of estrogenic actions of o, p'DDT: Interactions with the estrogen receptor
-
Kupfer, D., Bulger, W. H. (1976). Studies on the mechanism of estrogenic actions of o, p'DDT: interactions with the estrogen receptor. Pest. Biochem. Physiol. 6:567-570.
-
(1976)
Pest. Biochem. Physiol.
, vol.6
, pp. 567-570
-
-
Kupfer, D.1
Bulger, W.H.2
-
40
-
-
0017363573
-
Interactions of o, p'DDT with the estrogen-binding protein (EBP) in human mammary and uterine tumors
-
Kupfer, D., Bulger, W. H. (1977). Interactions of o, p'DDT with the estrogen-binding protein (EBP) in human mammary and uterine tumors. Res. Commun. Chem. Pathol. Pharmacol. 16:451-462.
-
(1977)
Res. Commun. Chem. Pathol. Pharmacol.
, vol.16
, pp. 451-462
-
-
Kupfer, D.1
Bulger, W.H.2
-
41
-
-
0018667377
-
A novel in vitro method for demonstrating proestrogens: Metabolism of methoxychlor and o, p'DDT by liver microsomes in the presence of uteri and effects of intracellular distribution of estrogen receptors
-
Kupfer, D., Bulger, W. H. (1979). A novel in vitro method for demonstrating proestrogens: metabolism of methoxychlor and o, p'DDT by liver microsomes in the presence of uteri and effects of intracellular distribution of estrogen receptors. Life Sci. 25:975-984.
-
(1979)
Life Sci.
, vol.25
, pp. 975-984
-
-
Kupfer, D.1
Bulger, W.H.2
-
42
-
-
0025004986
-
Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE)
-
Kupfer, D., Bulger, W. H. (1990). Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). FEBS Lett. 261:59-62.
-
(1990)
FEBS Lett.
, vol.261
, pp. 59-62
-
-
Kupfer, D.1
Bulger, W.H.2
-
43
-
-
0031008040
-
Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor
-
Levenson, A. S., Catherine, W. M., Jordan, V. C. (1997). Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor. J. Steroid Biochem. Mol. Biol. 60:261-268.
-
(1997)
J. Steroid Biochem. Mol. Biol.
, vol.60
, pp. 261-268
-
-
Levenson, A.S.1
Catherine, W.M.2
Jordan, V.C.3
-
44
-
-
2642593030
-
The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor
-
Levenson, A. S., Jordan, V. C. (1998). The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor. Cancer Res. 58:1872-1875.
-
(1998)
Cancer Res.
, vol.58
, pp. 1872-1875
-
-
Levenson, A.S.1
Jordan, V.C.2
-
45
-
-
0027711850
-
Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human
-
Li, H. C., Mani, C., Kupfer, D. (1993). Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human. J. Biol. Chem. 8:195-206.
-
(1993)
J. Biol. Chem.
, vol.8
, pp. 195-206
-
-
Li, H.C.1
Mani, C.2
Kupfer, D.3
-
46
-
-
0020587401
-
An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro
-
Lieberman, M. E., Gorski, J., Jordan, V. C. (1983a). An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro. J. Biol. Chem. 258:4741-4745.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 4741-4745
-
-
Lieberman, M.E.1
Gorski, J.2
Jordan, V.C.3
-
47
-
-
0020585962
-
Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro
-
Lieberman, M. E., Jordan, V. C., Fritsch, M., Santos, M. A., Gorski, J. (1983b). Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro. J. Biol. Chem. 258:4734-4740.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 4734-4740
-
-
Lieberman, M.E.1
Jordan, V.C.2
Fritsch, M.3
Santos, M.A.4
Gorski, J.5
-
48
-
-
0022496053
-
National Institutes of Health Consensus Development Conference: Adjuvant chemotherapy and endocrine therapy for breast cancer. Editorial Overview
-
Lippman, M. E., Chabner, B. A. (1986). National Institutes of Health Consensus Development Conference: Adjuvant chemotherapy and endocrine therapy for breast cancer. Editorial Overview. NCI Monograph 1:5-10.
-
(1986)
NCI Monograph
, vol.1
, pp. 5-10
-
-
Lippman, M.E.1
Chabner, B.A.2
-
49
-
-
0035328727
-
Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor {{alpha}} complex
-
Liu, H., Lee, E.-S., Reyes, A. D. L., Zapf, J. W., Jordan, V. C. (2001). Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor {{alpha}} complex. Cancer Res. 61:3632-3639.
-
(2001)
Cancer Res.
, vol.61
, pp. 3632-3639
-
-
Liu, H.1
Lee, E.-S.2
Reyes, A.D.L.3
Zapf, J.W.4
Jordan, V.C.5
-
50
-
-
0034665358
-
Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351
-
MacGregor Schafer, J., Liu, H., Bentrem, D. J., Zapf, J. W., Jordan, V. C. (2000). Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351. Cancer Res. 60:5097-5105.
-
(2000)
Cancer Res.
, vol.60
, pp. 5097-5105
-
-
MacGregor Schafer, J.1
Liu, H.2
Bentrem, D.J.3
Zapf, J.W.4
Jordan, V.C.5
-
51
-
-
0027221052
-
Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-Demethylation and 4-Hydroxylation
-
Mani, C., Gelboin, H. V., Park, S. S., Pearce, R., Parkinson, A., Kupfer, D. (1993a). Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-Demethylation and 4-Hydroxylation. Drug Metab. Dispos. 21:645-656.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 645-656
-
-
Mani, C.1
Gelboin, H.V.2
Park, S.S.3
Pearce, R.4
Parkinson, A.5
Kupfer, D.6
-
52
-
-
0027198580
-
Metabolism of the antimammaary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-Oxidation
-
Mani, C., Hodgson, E., Kupfer, D. (1993b). Metabolism of the antimammaary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-Oxidation. Drug Metab. Dispos. 21:657-661.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 657-661
-
-
Mani, C.1
Hodgson, E.2
Kupfer, D.3
-
53
-
-
0026319776
-
Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: Possible involvement of flavin-containing monooxygenases in tamoxifen activation
-
Mani, C., Kupfer, D. (1991). Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation. Cancer Res. 51:6052-6058.
-
(1991)
Cancer Res.
, vol.51
, pp. 6052-6058
-
-
Mani, C.1
Kupfer, D.2
-
54
-
-
0028670421
-
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes
-
Mani, C., Pearce, R., Parkinson, A., Kupfer, D. (1994). Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis 15:2715-2720.
-
(1994)
Carcinogenesis
, vol.15
, pp. 2715-2720
-
-
Mani, C.1
Pearce, R.2
Parkinson, A.3
Kupfer, D.4
-
55
-
-
0025896783
-
Structure-activity relationships of nonisomerizable derivatives of tamoxifen: Importance of hydroxyl group and side chain positioning for biological activity
-
Murphy, C. S., Parker, C. J., McCague, R., Jordan, V. C. (1991). Structure-activity relationships of nonisomerizable derivatives of tamoxifen: importance of hydroxyl group and side chain positioning for biological activity. Mol. Pharmacol. 39:421-428.
-
(1991)
Mol. Pharmacol.
, vol.39
, pp. 421-428
-
-
Murphy, C.S.1
Parker, C.J.2
McCague, R.3
Jordan, V.C.4
-
56
-
-
0015968498
-
Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17beta-(3H) estradiol binding to rat uterine receptor
-
Nelson, J. A. (1974). Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17beta-(3H) estradiol binding to rat uterine receptor. Biochem. Pharmacol. 23:447-451.
-
(1974)
Biochem. Pharmacol.
, vol.23
, pp. 447-451
-
-
Nelson, J.A.1
-
57
-
-
0019513409
-
Estrogenic activities of methoxychlor metabolites
-
Ousterhout, J. M., Struck, R. F., Nelson, J. A. (1981). Estrogenic activities of methoxychlor metabolites. Biochem. Pharmacol. 30:2869-2871.
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 2869-2871
-
-
Ousterhout, J.M.1
Struck, R.F.2
Nelson, J.A.3
-
58
-
-
0034989609
-
Understanding the genotoxicity of tamoxifen?
-
Phillips, D. H. (2001). Understanding the genotoxicity of tamoxifen? Carcinogenesis 22:839-849.
-
(2001)
Carcinogenesis
, vol.22
, pp. 839-849
-
-
Phillips, D.H.1
-
59
-
-
0029985407
-
Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: Comparisons between human, rat and mouse hepatocytes
-
Phillips, D. H., Carmichael, P. L., Hewer, A., Cole, K. J., Hardcastle, I. R., Poon, G. K., Keogh, A., Strain, A. J. (1996). Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes. Carcinogenesis 17:89-94.
-
(1996)
Carcinogenesis
, vol.17
, pp. 89-94
-
-
Phillips, D.H.1
Carmichael, P.L.2
Hewer, A.3
Cole, K.J.4
Hardcastle, I.R.5
Poon, G.K.6
Keogh, A.7
Strain, A.J.8
-
60
-
-
0024353118
-
A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer
-
Powles, T. J., Hardy, J. R., Ashley, S. E., Farrington, G. M., Cosgrove, D., Davey, J. B., Dowsett, M., McKinna, J. A., Nash, A. G., Sinnett, H. D. (1989). A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer. Br. J. Cancer 60:126-131.
-
(1989)
Br. J. Cancer
, vol.60
, pp. 126-131
-
-
Powles, T.J.1
Hardy, J.R.2
Ashley, S.E.3
Farrington, G.M.4
Cosgrove, D.5
Davey, J.B.6
Dowsett, M.7
McKinna, J.A.8
Nash, A.G.9
Sinnett, H.D.10
-
61
-
-
21144447743
-
Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: A prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen
-
Rouanet, P., Linares-Cruz, G., Dravet, F., Poujol, S., Gourgou, S., Simony-Lafontaine, J., Grenier, J., Kramar, A., Girault, J., Le Nestour, E., Maudelonde, T. (2005). Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: a prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen. J. Clin. Oncol. 23:2980-2984.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 2980-2984
-
-
Rouanet, P.1
Linares-Cruz, G.2
Dravet, F.3
Poujol, S.4
Gourgou, S.5
Simony-Lafontaine, J.6
Grenier, J.7
Kramar, A.8
Girault, J.9
Le Nestour, E.10
Maudelonde, T.11
-
62
-
-
0032446607
-
The structural basis of estrogen receptor/co-activator recognition and the antagonism of this interaction by tamoxifen
-
Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., Greene, G. L. (1998). The structural basis of estrogen receptor/co-activator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-937.
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
Cheng, L.4
Kushner, P.J.5
Agard, D.A.6
Greene, G.L.7
-
63
-
-
0027308685
-
The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat
-
Williams, G. M., Iatropoulos, M. J., Djordjevic, M. V., Kaltenberg, O. P. (1993). The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis 14:315-317.
-
(1993)
Carcinogenesis
, vol.14
, pp. 315-317
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Djordjevic, M.V.3
Kaltenberg, O.P.4
-
64
-
-
0028093565
-
The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain
-
Wolf, D.M., Jordan, V. C. (1994). The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain. Br. Cancer Res. Treat. 31:129-138.
-
(1994)
Br. Cancer Res. Treat.
, vol.31
, pp. 129-138
-
-
Wolf, D.M.1
Jordan, V.C.2
|