메뉴 건너뛰기




Volumn 38, Issue 1-2, 2006, Pages 117-127

Activated estrogens and antiestrogens: A 30-year journey with David Kupfer

Author keywords

Antiestrogens; DDT; Estrogen receptor; Insecticides; Methoxychlor; Tamoxifen

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; ANTIESTROGEN; ENDOCRINE DISRUPTOR; ESTROGEN; ESTROGEN RECEPTOR; INSECTICIDE; METHOXYCHLOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TAMOXIFEN CITRATE;

EID: 33646690059     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530600569893     Document Type: Review
Times cited : (1)

References (64)
  • 2
    • 0019132163 scopus 로고
    • Evidence for the metabolic activation of non-steroidal antioestrogens: A study of structure-activity relationships
    • Allen, K. E., Clark, E. R., Jordan, V. C. (1980). Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships. Br J. Pharmacol 71:83-91.
    • (1980) Br. J. Pharmacol. , vol.71 , pp. 83-91
    • Allen, K.E.1    Clark, E.R.2    Jordan, V.C.3
  • 3
    • 0242526030 scopus 로고    scopus 로고
    • Distinct molecular conformations of the estrogen receptor alpha complex exploited by environmental estrogens
    • Bentrem, D., Fox, J. E., Pearce, S. T., Liu, H., Pappas, S., Kupfer, D., Zapf, J. W., Jordan, V. C. (2003). Distinct molecular conformations of the estrogen receptor alpha complex exploited by environmental estrogens. Cancer Res. 63:7490-7496.
    • (2003) Cancer Res. , vol.63 , pp. 7490-7496
    • Bentrem, D.1    Fox, J.E.2    Pearce, S.T.3    Liu, H.4    Pappas, S.5    Kupfer, D.6    Zapf, J.W.7    Jordan, V.C.8
  • 5
    • 0021987828 scopus 로고
    • Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants
    • Bulger, W. H., Feil, V. J., Kupfer, D. (1985). Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants. Mol. Pharmacol. 27:115-124.
    • (1985) Mol. Pharmacol. , vol.27 , pp. 115-124
    • Bulger, W.H.1    Feil, V.J.2    Kupfer, D.3
  • 6
    • 0018099018 scopus 로고
    • Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. I. Comparison with estradiol-17 beta activity
    • Bulger, W. H., Kupfer, D. (1978). Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. I. Comparison with estradiol-17 beta activity. Pest. Biochem. Physiol. 8:253-262.
    • (1978) Pest. Biochem. Physiol. , vol.8 , pp. 253-262
    • Bulger, W.H.1    Kupfer, D.2
  • 7
    • 0020964670 scopus 로고
    • Estrogenic action of DDT analogs
    • Bulger, W. H., Kupfer, D. (1983). Estrogenic action of DDT analogs. Am. J. Ind. Med. 4:163-173.
    • (1983) Am. J. Ind. Med. , vol.4 , pp. 163-173
    • Bulger, W.H.1    Kupfer, D.2
  • 8
    • 0018015306 scopus 로고
    • Interactions of chlorinated hydrocarbon pesticides with the 8S estrogen-binding protein in rat testes
    • Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978a). Interactions of chlorinated hydrocarbon pesticides with the 8S estrogen-binding protein in rat testes. Steroids 32.
    • (1978) Steroids , vol.32
    • Bulger, W.H.1    Muccitelli, R.M.2    Kupfer, D.3
  • 9
    • 0018009080 scopus 로고
    • Interactions of methoxychlor, methoxychlor base-soluble contaminant, and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane with rat uterine estrogen receptor
    • Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978b). Interactions of methoxychlor, methoxychlor base-soluble contaminant, and 2,2-bis(p- hydroxyphenyl)-1,1,1-trichloroethane with rat uterine estrogen receptor. J. Toxicol. Environ. Health 4:881-893.
    • (1978) J. Toxicol. Environ. Health , vol.4 , pp. 881-893
    • Bulger, W.H.1    Muccitelli, R.M.2    Kupfer, D.3
  • 10
    • 0018078757 scopus 로고
    • Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites: Role of hepatic mono-oxygenase in methoxychlor activation
    • Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978c). Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites: role of hepatic mono-oxygenase in methoxychlor activation. Biochem. Pharmacol. 27:2417-2423.
    • (1978) Biochem. Pharmacol. , vol.27 , pp. 2417-2423
    • Bulger, W.H.1    Muccitelli, R.M.2    Kupfer, D.3
  • 11
    • 0018102530 scopus 로고
    • Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. II. Kinetic characteristics of omithine decarboxylase induced by DDT analogs and estradiol
    • Bulger, W. H., Muccitelli, R. M., Kupfer, D. (1978d). Studies on the induction of rat uterine ornithine decarboxylase by DDT analogs. II. Kinetic characteristics of omithine decarboxylase induced by DDT analogs and estradiol. Pest. Biochem. Physiol. 27:263-270.
    • (1978) Pest. Biochem. Physiol. , vol.27 , pp. 263-270
    • Bulger, W.H.1    Muccitelli, R.M.2    Kupfer, D.3
  • 12
    • 0020645907 scopus 로고
    • Covalent binding of [14C]methoxychlor metabolite(s) to rat liver microsomal components
    • Bulger, W. H., Temple, J. E., Kupfer, D. (1983). Covalent binding of [14C]methoxychlor metabolite(s) to rat liver microsomal components. Toxicol. Appl. Pharmacol. 68:367-374.
    • (1983) Toxicol. Appl. Pharmacol. , vol.68 , pp. 367-374
    • Bulger, W.H.1    Temple, J.E.2    Kupfer, D.3
  • 13
    • 0015069359 scopus 로고
    • A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI 46474
    • Cole, M. P., Jones, C. T., Todd, I. D. (1971). A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI 46474. Br. J. Cancer. 25:270-275.
    • (1971) Br. J. Cancer. , vol.25 , pp. 270-275
    • Cole, M.P.1    Jones, C.T.2    Todd, I.D.3
  • 14
    • 51149188436 scopus 로고
    • Synthetic oestrogenic agents without the phenanthrene nucleus
    • Dodds, E. C., Lawson, W. (1936). Synthetic oestrogenic agents without the phenanthrene nucleus. Nature 137:996.
    • (1936) Nature , vol.137 , pp. 996
    • Dodds, E.C.1    Lawson, W.2
  • 15
    • 0024269590 scopus 로고
    • Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women
    • EBCTCG. (1988). Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women. N. Engl. J. Med. 319:1681-1692.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 1681-1692
  • 16
    • 0015748908 scopus 로고
    • The metabolism of tamoxifen (ICI 46,474) Part II in femal patients
    • Fromson, J. M., Pearson, S., Bramah, S. (1973). The metabolism of tamoxifen (ICI 46,474) Part II in femal patients. Xenobiotica 3:711-713.
    • (1973) Xenobiotica , vol.3 , pp. 711-713
    • Fromson, J.M.1    Pearson, S.2    Bramah, S.3
  • 17
    • 0027201501 scopus 로고
    • Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves, P., Goonetilleke, R., Nunn, G., Topham, J., Orton, T. (1993). Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res. 53:3919-3924.
    • (1993) Cancer Res. , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 18
    • 0026606580 scopus 로고
    • Induction of covalent DNA adducts in rodents by tamoxifen
    • Han, X. L., Liehr, J. G. (1992). Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Res. 52:1360-1363.
    • (1992) Cancer Res. , vol.52 , pp. 1360-1363
    • Han, X.L.1    Liehr, J.G.2
  • 19
    • 0027428568 scopus 로고
    • Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Cr1:CD(BR) rats
    • Hard, G. C., Iatropoulos, M. J., Jordan, K., Radi, L., Kaltenberg, O. P., Imondi, A. R., Williams, G. M. (1993). Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Cr1:CD(BR) rats. Cancer Res. 53:4534-4541.
    • (1993) Cancer Res. , vol.53 , pp. 4534-4541
    • Hard, G.C.1    Iatropoulos, M.J.2    Jordan, K.3    Radi, L.4    Kaltenberg, O.P.5    Imondi, A.R.6    Williams, G.M.7
  • 20
    • 0014039539 scopus 로고
    • Mode of action of I.C.I. 46,474 in preventing implantation in rats
    • Harper, M. J., Walpole, A. L. (1967a). Mode of action of I.C.I. 46,474 in preventing implantation in rats. J. Endocrinol. 37:83-92.
    • (1967) J. Endocrinol. , vol.37 , pp. 83-92
    • Harper, M.J.1    Walpole, A.L.2
  • 21
    • 0014053604 scopus 로고
    • A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
    • Harper, M. J., Walpole, A. L. (1967b). A new derivative of triphenylethylene: effect on implantation and mode of action in rats. J. Reprod. Fertil. 13:101-119.
    • (1967) J. Reprod. Fertil. , vol.13 , pp. 101-119
    • Harper, M.J.1    Walpole, A.L.2
  • 23
    • 0016592723 scopus 로고
    • Detection of the 8 S oestrogen-binding component in human uterine endometrium during the menstrual cycle
    • Hunter, R. E., Jordan, V. C. (1975). Detection of the 8 S oestrogen-binding component in human uterine endometrium during the menstrual cycle. J. Endocrinol. 65:457-458.
    • (1975) J. Endocrinol. , vol.65 , pp. 457-458
    • Hunter, R.E.1    Jordan, V.C.2
  • 24
    • 0018893540 scopus 로고
    • Stimulaation of uterine deoxyribonucleic acid synthesis by 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane (o, p'DDT)
    • Ireland, J. S., Mukku, V. R., Robison, A. K., Stancel, G. M. (1980). Stimulaation of uterine deoxyribonucleic acid synthesis by 1,1,1-trichloro-2-(p- chlorophenyl)-2-(o-chlorophenyl)ethane (o, p'DDT). Biochem. Pharmacol. 29:1469-1474.
    • (1980) Biochem. Pharmacol. , vol.29 , pp. 1469-1474
    • Ireland, J.S.1    Mukku, V.R.2    Robison, A.K.3    Stancel, G.M.4
  • 26
    • 0001464486 scopus 로고
    • Basic guides to the mechanism of estrogen action
    • Jensen, E. V., Jacobson, H. I. (1962). Basic guides to the mechanism of estrogen action. Recent Progr. Hormone Res. 18:387-414.
    • (1962) Recent Progr. Hormone Res. , vol.18 , pp. 387-414
    • Jensen, E.V.1    Jacobson, H.I.2
  • 27
    • 0026520381 scopus 로고
    • Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor
    • Jiang, S. Y., Jordan, V. C. (1992). Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J. Natl. Cancer Inst. 84:580-591.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 580-591
    • Jiang, S.Y.1    Jordan, V.C.2
  • 28
    • 0016424339 scopus 로고
    • Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse
    • Jordan, V. C. (1975). Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse. J. Reprod. Fertil. 42:251-258.
    • (1975) J. Reprod. Fertil. , vol.42 , pp. 251-258
    • Jordan, V.C.1
  • 29
    • 0037364074 scopus 로고    scopus 로고
    • Tamoxifen: A most unlikely pioneering medicine
    • Jordan, V. C. (2003a). Tamoxifen: a most unlikely pioneering medicine. Nature Reviews Drug Discovery 2:205-213.
    • (2003) Nature Reviews Drug Discovery , vol.2 , pp. 205-213
    • Jordan, V.C.1
  • 30
    • 0037621719 scopus 로고    scopus 로고
    • Antiestrogens and selective estrogen receptor modulators as multifunctional medicines Part II: Clinical Considerations and New Agents
    • Jordan, V. C. (2003b). Antiestrogens and selective estrogen receptor modulators as multifunctional medicines Part II: Clinical Considerations and New Agents. J. Med. Chem. 46:1082-1111.
    • (2003) J. Med. Chem. , vol.46 , pp. 1082-1111
    • Jordan, V.C.1
  • 31
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan, V. C., Collins, M. M., Rowsby, L., Prestwich, G. (1977). A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J. Endocrinol. 75:305-316.
    • (1977) J. Endocrinol. , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3    Prestwich, G.4
  • 32
    • 0016425439 scopus 로고
    • Inhibition of oestradiol binding to mouse uterine and vaginal oestrogen receptors by triphenylethylenes
    • Jordan, V. C., Koerner, S. (1975a). Inhibition of oestradiol binding to mouse uterine and vaginal oestrogen receptors by triphenylethylenes. J. Endocrinol. 64:193-194.
    • (1975) J. Endocrinol. , vol.64 , pp. 193-194
    • Jordan, V.C.1    Koerner, S.2
  • 33
    • 0016638259 scopus 로고
    • Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor
    • Jordan, V. C., Koerner, S. (1975b). Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor. Eur. J. Cancer 11:205-206.
    • (1975) Eur. J. Cancer , vol.11 , pp. 205-206
    • Jordan, V.C.1    Koerner, S.2
  • 35
    • 0025220695 scopus 로고
    • Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrane treated rats
    • Juedes, M. J., Kupfer, D. (1990). Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrane treated rats. Drug Metab. Dispos. 18:131-137.
    • (1990) Drug Metab. Dispos. , vol.18 , pp. 131-137
    • Juedes, M.J.1    Kupfer, D.2
  • 36
    • 0013829730 scopus 로고
    • Hormone therapy for advanced breast cancer
    • Kennedy, B. J. (1965). Hormone therapy for advanced breast cancer. Cancer 18:1551-1557.
    • (1965) Cancer , vol.18 , pp. 1551-1557
    • Kennedy, B.J.1
  • 37
    • 0016562704 scopus 로고
    • Effects of pesticides and related compounds on steroid metabolism and function
    • Kupfer, D. (1975). Effects of pesticides and related compounds on steroid metabolism and function. CRC Crit. Rev. Toxicol. 4:83-124.
    • (1975) CRC Crit. Rev. Toxicol. , vol.4 , pp. 83-124
    • Kupfer, D.1
  • 38
    • 0017028095 scopus 로고
    • Interactions of chlorinated hydrocarbons with steroid hormones
    • Kupfer, D. (1976). Interactions of chlorinated hydrocarbons with steroid hormones. Fed. Proc. 35:2603-2608.
    • (1976) Fed. Proc. , vol.35 , pp. 2603-2608
    • Kupfer, D.1
  • 39
    • 0017059441 scopus 로고
    • Studies on the mechanism of estrogenic actions of o, p'DDT: Interactions with the estrogen receptor
    • Kupfer, D., Bulger, W. H. (1976). Studies on the mechanism of estrogenic actions of o, p'DDT: interactions with the estrogen receptor. Pest. Biochem. Physiol. 6:567-570.
    • (1976) Pest. Biochem. Physiol. , vol.6 , pp. 567-570
    • Kupfer, D.1    Bulger, W.H.2
  • 40
    • 0017363573 scopus 로고
    • Interactions of o, p'DDT with the estrogen-binding protein (EBP) in human mammary and uterine tumors
    • Kupfer, D., Bulger, W. H. (1977). Interactions of o, p'DDT with the estrogen-binding protein (EBP) in human mammary and uterine tumors. Res. Commun. Chem. Pathol. Pharmacol. 16:451-462.
    • (1977) Res. Commun. Chem. Pathol. Pharmacol. , vol.16 , pp. 451-462
    • Kupfer, D.1    Bulger, W.H.2
  • 41
    • 0018667377 scopus 로고
    • A novel in vitro method for demonstrating proestrogens: Metabolism of methoxychlor and o, p'DDT by liver microsomes in the presence of uteri and effects of intracellular distribution of estrogen receptors
    • Kupfer, D., Bulger, W. H. (1979). A novel in vitro method for demonstrating proestrogens: metabolism of methoxychlor and o, p'DDT by liver microsomes in the presence of uteri and effects of intracellular distribution of estrogen receptors. Life Sci. 25:975-984.
    • (1979) Life Sci. , vol.25 , pp. 975-984
    • Kupfer, D.1    Bulger, W.H.2
  • 42
    • 0025004986 scopus 로고
    • Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE)
    • Kupfer, D., Bulger, W. H. (1990). Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). FEBS Lett. 261:59-62.
    • (1990) FEBS Lett. , vol.261 , pp. 59-62
    • Kupfer, D.1    Bulger, W.H.2
  • 43
    • 0031008040 scopus 로고    scopus 로고
    • Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor
    • Levenson, A. S., Catherine, W. M., Jordan, V. C. (1997). Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor. J. Steroid Biochem. Mol. Biol. 60:261-268.
    • (1997) J. Steroid Biochem. Mol. Biol. , vol.60 , pp. 261-268
    • Levenson, A.S.1    Catherine, W.M.2    Jordan, V.C.3
  • 44
    • 2642593030 scopus 로고    scopus 로고
    • The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor
    • Levenson, A. S., Jordan, V. C. (1998). The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor. Cancer Res. 58:1872-1875.
    • (1998) Cancer Res. , vol.58 , pp. 1872-1875
    • Levenson, A.S.1    Jordan, V.C.2
  • 45
    • 0027711850 scopus 로고
    • Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human
    • Li, H. C., Mani, C., Kupfer, D. (1993). Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human. J. Biol. Chem. 8:195-206.
    • (1993) J. Biol. Chem. , vol.8 , pp. 195-206
    • Li, H.C.1    Mani, C.2    Kupfer, D.3
  • 46
    • 0020587401 scopus 로고
    • An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro
    • Lieberman, M. E., Gorski, J., Jordan, V. C. (1983a). An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro. J. Biol. Chem. 258:4741-4745.
    • (1983) J. Biol. Chem. , vol.258 , pp. 4741-4745
    • Lieberman, M.E.1    Gorski, J.2    Jordan, V.C.3
  • 47
    • 0020585962 scopus 로고
    • Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro
    • Lieberman, M. E., Jordan, V. C., Fritsch, M., Santos, M. A., Gorski, J. (1983b). Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro. J. Biol. Chem. 258:4734-4740.
    • (1983) J. Biol. Chem. , vol.258 , pp. 4734-4740
    • Lieberman, M.E.1    Jordan, V.C.2    Fritsch, M.3    Santos, M.A.4    Gorski, J.5
  • 48
    • 0022496053 scopus 로고
    • National Institutes of Health Consensus Development Conference: Adjuvant chemotherapy and endocrine therapy for breast cancer. Editorial Overview
    • Lippman, M. E., Chabner, B. A. (1986). National Institutes of Health Consensus Development Conference: Adjuvant chemotherapy and endocrine therapy for breast cancer. Editorial Overview. NCI Monograph 1:5-10.
    • (1986) NCI Monograph , vol.1 , pp. 5-10
    • Lippman, M.E.1    Chabner, B.A.2
  • 49
    • 0035328727 scopus 로고    scopus 로고
    • Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor {{alpha}} complex
    • Liu, H., Lee, E.-S., Reyes, A. D. L., Zapf, J. W., Jordan, V. C. (2001). Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor {{alpha}} complex. Cancer Res. 61:3632-3639.
    • (2001) Cancer Res. , vol.61 , pp. 3632-3639
    • Liu, H.1    Lee, E.-S.2    Reyes, A.D.L.3    Zapf, J.W.4    Jordan, V.C.5
  • 50
    • 0034665358 scopus 로고    scopus 로고
    • Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351
    • MacGregor Schafer, J., Liu, H., Bentrem, D. J., Zapf, J. W., Jordan, V. C. (2000). Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351. Cancer Res. 60:5097-5105.
    • (2000) Cancer Res. , vol.60 , pp. 5097-5105
    • MacGregor Schafer, J.1    Liu, H.2    Bentrem, D.J.3    Zapf, J.W.4    Jordan, V.C.5
  • 51
    • 0027221052 scopus 로고
    • Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-Demethylation and 4-Hydroxylation
    • Mani, C., Gelboin, H. V., Park, S. S., Pearce, R., Parkinson, A., Kupfer, D. (1993a). Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-Demethylation and 4-Hydroxylation. Drug Metab. Dispos. 21:645-656.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 645-656
    • Mani, C.1    Gelboin, H.V.2    Park, S.S.3    Pearce, R.4    Parkinson, A.5    Kupfer, D.6
  • 52
    • 0027198580 scopus 로고
    • Metabolism of the antimammaary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-Oxidation
    • Mani, C., Hodgson, E., Kupfer, D. (1993b). Metabolism of the antimammaary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-Oxidation. Drug Metab. Dispos. 21:657-661.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 657-661
    • Mani, C.1    Hodgson, E.2    Kupfer, D.3
  • 53
    • 0026319776 scopus 로고
    • Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: Possible involvement of flavin-containing monooxygenases in tamoxifen activation
    • Mani, C., Kupfer, D. (1991). Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation. Cancer Res. 51:6052-6058.
    • (1991) Cancer Res. , vol.51 , pp. 6052-6058
    • Mani, C.1    Kupfer, D.2
  • 54
    • 0028670421 scopus 로고
    • Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes
    • Mani, C., Pearce, R., Parkinson, A., Kupfer, D. (1994). Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis 15:2715-2720.
    • (1994) Carcinogenesis , vol.15 , pp. 2715-2720
    • Mani, C.1    Pearce, R.2    Parkinson, A.3    Kupfer, D.4
  • 55
    • 0025896783 scopus 로고
    • Structure-activity relationships of nonisomerizable derivatives of tamoxifen: Importance of hydroxyl group and side chain positioning for biological activity
    • Murphy, C. S., Parker, C. J., McCague, R., Jordan, V. C. (1991). Structure-activity relationships of nonisomerizable derivatives of tamoxifen: importance of hydroxyl group and side chain positioning for biological activity. Mol. Pharmacol. 39:421-428.
    • (1991) Mol. Pharmacol. , vol.39 , pp. 421-428
    • Murphy, C.S.1    Parker, C.J.2    McCague, R.3    Jordan, V.C.4
  • 56
    • 0015968498 scopus 로고
    • Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17beta-(3H) estradiol binding to rat uterine receptor
    • Nelson, J. A. (1974). Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17beta-(3H) estradiol binding to rat uterine receptor. Biochem. Pharmacol. 23:447-451.
    • (1974) Biochem. Pharmacol. , vol.23 , pp. 447-451
    • Nelson, J.A.1
  • 58
    • 0034989609 scopus 로고    scopus 로고
    • Understanding the genotoxicity of tamoxifen?
    • Phillips, D. H. (2001). Understanding the genotoxicity of tamoxifen? Carcinogenesis 22:839-849.
    • (2001) Carcinogenesis , vol.22 , pp. 839-849
    • Phillips, D.H.1
  • 59
    • 0029985407 scopus 로고    scopus 로고
    • Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: Comparisons between human, rat and mouse hepatocytes
    • Phillips, D. H., Carmichael, P. L., Hewer, A., Cole, K. J., Hardcastle, I. R., Poon, G. K., Keogh, A., Strain, A. J. (1996). Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes. Carcinogenesis 17:89-94.
    • (1996) Carcinogenesis , vol.17 , pp. 89-94
    • Phillips, D.H.1    Carmichael, P.L.2    Hewer, A.3    Cole, K.J.4    Hardcastle, I.R.5    Poon, G.K.6    Keogh, A.7    Strain, A.J.8
  • 61
    • 21144447743 scopus 로고    scopus 로고
    • Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: A prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen
    • Rouanet, P., Linares-Cruz, G., Dravet, F., Poujol, S., Gourgou, S., Simony-Lafontaine, J., Grenier, J., Kramar, A., Girault, J., Le Nestour, E., Maudelonde, T. (2005). Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: a prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen. J. Clin. Oncol. 23:2980-2984.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2980-2984
    • Rouanet, P.1    Linares-Cruz, G.2    Dravet, F.3    Poujol, S.4    Gourgou, S.5    Simony-Lafontaine, J.6    Grenier, J.7    Kramar, A.8    Girault, J.9    Le Nestour, E.10    Maudelonde, T.11
  • 62
    • 0032446607 scopus 로고    scopus 로고
    • The structural basis of estrogen receptor/co-activator recognition and the antagonism of this interaction by tamoxifen
    • Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., Greene, G. L. (1998). The structural basis of estrogen receptor/co-activator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-937.
    • (1998) Cell , vol.95 , pp. 927-937
    • Shiau, A.K.1    Barstad, D.2    Loria, P.M.3    Cheng, L.4    Kushner, P.J.5    Agard, D.A.6    Greene, G.L.7
  • 63
  • 64
    • 0028093565 scopus 로고
    • The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain
    • Wolf, D.M., Jordan, V. C. (1994). The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain. Br. Cancer Res. Treat. 31:129-138.
    • (1994) Br. Cancer Res. Treat. , vol.31 , pp. 129-138
    • Wolf, D.M.1    Jordan, V.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.