Chronic alcoholics without Wernicke-Korsakoff syndrome or cirrhosis do not lose serotonergic neurons in the dorsal raphe nucleus

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 1, 1996, Pages 61-66

  Baker, K G ^a   Halliday, G M ^a,b   Kril, J J ^c   Harper, C G ^a,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

Alcoholism; Brainstem; Neurotoxicity; Serotonin

Indexed keywords

SEROTONIN;

ADULT; AGED; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; BRAIN STEM; CLINICAL ARTICLE; DORSAL RAPHE NUCLEUS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; MALE; NEUROTOXICITY; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; WERNICKE KORSAKOFF SYNDROME;

AGED; ALCOHOL AMNESTIC DISORDER; ALCOHOLISM; CELL COUNT; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER CIRRHOSIS, ALCOHOLIC; MALE; MIDDLE AGED; NEURONS; RAPHE NUCLEI; SEROTONIN; WERNICKE ENCEPHALOPATHY;

EID: 0029926044     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01045.x     Document Type: Article

References (20)

1. 1A receptor binding in the human brain post-mortem: Effects of age and alcohol. Brain Res 554:56-64, 1991
2. Ulrichsen J: Alterations in serotonin receptor subtypes in ethanol-dependent rats. Alcohol Alcohol 26:567-573, 1991
3. Balldin J, Berggren U, Engel J, Eriksson M: Neuroendocrine evidence for reduced serotonergic neurotransmission during heavy drinking. Alcohol Clin Exp Res 18:822-825, 1994
4. Gottfries CH, Oreland L, Wiberg A, Winblad B: Lowered monoamine oxidase activity in brains from alcoholic suicides. J Neurochem 25:667-673, 1975
5. Oreland L, Wiberg A, Winblad B, Fowler CJ, Gottfries C-G, Kiianmaa K: The activity of monoamine oxidase -A and -B in brains from chronic alcoholics. J Neural Transm 56:73-83, 1983
6. Ballenger JC, Goodwin FK, Major LF, Brown GL: Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry 36:224-227, 1979
7. Tollefson GD: Serotonin and alcohol: Interrelationships. Psychopathology 22(Suppl. 1):37-48, 1989
8. Wong DT, Threlkeld PG, Lumeng L, Li T-K: Higher density of serotonin 1-A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats. Life Sci 46:231-235, 1990
9. Zhou FC, Pu CF, Lumeng L, Li T-K: Fewer number of immunostained serotonergic neurons in raphe of alcohol-preferring rats. Alcohol Clin Exp Res 15:315, 1991
10. Zhou FC, Pu CF, Murphy J, Lumeng L, Li T-K: Serotonergic neurons in the alcohol preferring rats. Alcohol 11:397-403, 1994
11. Naranjo CA, Bremner KE: Evaluation of the effects of serotonin uptake inhibitors in alcoholics: A review, in Naranjo CA, Sellers EM (eds): Novel Pharmacological Interventions for Alcoholism. New York, Springer-Verlag, 1992, pp 105-117
12. Fuller RW: Clinical applications of 5-HT uptake inhibitors, in Bradley PB, Handley SL, Cooper SJ, Key BJ, Barnes NM, Coote JH (eds): Serotonin, CNS Receptors and Brain Function. Oxford, Pergamon Press, 1992, pp 255-270
13. 1A antagonist ondansetron in alcohol abuse and dependence. Alcohol Clin Exp Res 18:879-885, 1994
14. Mayes AR, Meudell PR, Mann D, Pickering A: Location of lesions in Korsakoff's syndrome: Neuropsychological and neuropathological data on two patients. Cortex 24:367-388, 1988
15. Victor M, Adams RD, Collins GH: The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition. Philadelphia, FA Davies, 1989
16. McEntee W, Mair R: The Korsakoff syndrome: A neurochemical perspective. Trends Neurosci 13:340-344, 1990
17. Butterworth RF, Kril JJ, Harper CG: Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome. Alcohol Clin Exp Res 17:1084-1088, 1993
18. Savolainen VT, Liesto K, Männikkö, A Penttilä, Karhunen PJ: Alcohol consumption and alcoholic liver disease: Evidence of a threshold level of effects of ethanol. Alcohol Clin Exp Res 17:1112-1117, 1993
19. Tarter RE, Arria A, Van Thiel DH: Liver-brain interactions in alcoholism, in Hunt WA, Nixon SJ (eds): Alcohol-Induced Brain Damage. Rockville, MD, NIH Publication No. 93-3549, 1993, p 415
20. Butterworth RF: Brain damage and dysfunction resulting from alcoholic cirrhosis. Alcohol Clin Exp Res 18:7A, 1994