Dermal fibroblasts sustain proliferation of activated T cells via membrane-bound interleukin-15 upon long-term stimulation with tumor necrosis factor-α

Journal of Investigative Dermatology

Volumn 116, Issue 1, 2001, Pages 102-109

  Rappl, G ^a   Kapsokefalou, A ^a   Heuser, C ^a   Rossler M ^a   Ugurel, S ^a   Tilgen, W ^a   Reinhold, U ^a   Abken, H ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cell to cell interactions; Human fibroblasts; Inflammation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CELL SURFACE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DERMIS; DISCOID LUPUS ERYTHEMATOSUS; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTER; GROWTH STIMULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0035138935     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.00239.x     Document Type: Article

References (35)

1. Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis
2. Adhesion molecules in cutaneous inflammation
3. Human dermal fibroblasts express eotaxin: Molecular cloning, mRNA expression, and identification of eotaxin sequence variants
4. Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines
5. Lymphocyte-fibroblast adhesion: A useful model for analysis of the interaction of the leucocyte integrin LFA-1 with ICAM-1
6. Expression and role of IL-15 in post-burn hypertrophic scars
7. Macrophage-derived cytokine and nuclear factor κB p 65 expression in synovial membrane and skin of patients with psoriatic arthritis
8. Up-regulation of NK cytotoxic activity via IL-15 induction by different viruses: A comparative study
9. Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms
10. Expression of VCAM-1 and VLA-4 dependent T-lymphocyte adhesion to dermal fibroblasts stimulated with proinflammatory cytokines
11. Interleukin-15 is not a constitutive cytokine in the epidermis, but is inducible in culture or inflammatory conditions
12. Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis
13. Identification of a membrane-associated interleukin 1 in macrophages
14. The long signale peptide isoform and its alternative processing direct the intracellular trafficking of IL-15
15. IL-15 promotes survival but not effector function differentiation of CD8+ TCRαβ+ intestinal intraepithelial lymphocytes
16. Evidence for the existence of two forms of membrane tumor necrosis factor: An integral protein and a molecule attached to its receptor
17. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
18. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
19. Mast cells induce T-cell adhesion to human fibroblasts by regulating intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression
20. Tumor necrosis factor-alpha but not interleukin-1 induces polymorphonuclear leucocyte migration through fibroblast layers by a fibroblast-dependent mechanism
21. Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells
22. Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-upregulated interleukin-15
23. Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo
24. Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-α-stimulated dermal fibroblasts
25. Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms
26. IL-15 induces the expression of chemokines and their receptors in T lymphocytes
27. Intestinal epithelial cells both express and respond to interleukin-15
28. Intercellular adhesion molecule-1 in the inflammatory response
29. Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues
30. Cytokine interactions in human immunodeficiency virus-infected individuals: Roles of interleuken (IL)-2, IL-12 and IL-15
31. Detection of the chemokine RANTES in cytokine-stimilated human dermal fibroblast
32. Generation of secretable and nonsecretable interleuken-15 isoforms through alternate usage of signal pepsides
33. Interleuken-1 and transforming growth factor-alpha: Synergestic stimulation of metallloproteinases PGE 2, and proliferation in human fibroblast
34. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host responseto intracellular pahtogens
35. Chemoattraction of human blood T lymphocytes by interleuken-15