On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 Å resolution

Acta Crystallographica Section D: Biological Crystallography

Volumn 62, Issue 5, 2006, Pages 489-497

  Dušková, Jarmila ^a   Dohnálek, Jan ^a   Skálová, Tereza ^a   Petroková, Hana ^a   Vondráčková, Eva ^a   Hradílek, Martin ^b   Konvalinka, Jan ^b   Souček, Milan ^b   Brynda, Jiří ^c   Fábry, Milan ^c   Sedláček, Juraj ^c   Hašek, Jindřich ^a  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

BOC PHE ((R) CH(OH)CH2NH) PHE GLU PHE NH2; BOC-PHE-((R)-CH(OH)CH2NH)-PHE-GLU-PHE-NH2; ETHANOLAMINE DERIVATIVE; OLIGOPEPTIDE; PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; METABOLISM; PROTEIN BINDING; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ETHANOLAMINES; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HYDROGEN BONDING; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; STEREOISOMERISM;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33646545688     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444906006718     Document Type: Article

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