Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls

Schizophrenia Research

Volumn 83, Issue 2-3, 2006, Pages 173-177

  Kozlovsky, Nitsan ^a   Scarr, Elizabeth ^b   Dean, Brian ^b   Agam, Galila ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

Calcineurin; Postmortem brain; Protein levels; Schizophrenia

Indexed keywords

ANTIBODY; CALCINEURIN;

ADULT; ARTICLE; AUTOPSY; BRAIN REGION; CONTROLLED STUDY; ENZYME SUBUNIT; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; SEX; TISSUE; WESTERN BLOTTING;

ADULT; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CALCINEURIN; CASE-CONTROL STUDIES; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; POSTMORTEM CHANGES; PREFRONTAL CORTEX; SCHIZOPHRENIA;

EID: 33646492849     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2005.12.843     Document Type: Article

References (27)

1. Aramburu J., Rao A., and Klee C.B. Calcineurin: from structure to function. Curr. Top. Cell. Regul. 36 (2000) 237-295
2. Carlsson A., Waters N., Holm-Waters S., Tedroff J., Nilsson M., and Carlsson M.L. Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 237-260
3. Coghlan V.M., Perrino B.A., Howard M., Langeberg L.K., Hicks J.B., Gallatin W.M., and Scott J.D. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science 267 (1995) 108-111
4. Coyle J.T., and Tsai G. NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia. Int. Rev. Neurobiol. 59 (2004) 491-515
5. Eastwood S.L., Burnet P.W., and Harrison P.J. Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. Biol. Psychiatry 57 (2005) 702-710
6. Gerber D.J., Hall D., Miyakawa T., Demars S., Gogos J.A., Karayiorgou M., and Tonegawa S. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 8993-8998 (Electronic publication 2003 Jul 8998)
7. Greengard P. The neurobiology of slow synaptic transmission. Science 294 (2001) 1024-1030
8. Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D., Haroutunian V., and Fienberg A.A. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 4746-4751
9. Hill C., Keks N., Roberts S., Opeskin K., Dean B., MacKinnon A., and Copolov D. Problem of diagnosis in postmortem brain studies of schizophrenia. Am. J. Psychiatry 153 (1996) 533-537
10. Klee C.B., Crouch T.H., and Krinks M.H. Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 6270-6273
11. Kontkanen O., Toronen P., Lakso M., Wong G., and Castren E. Antipsychotic drug treatment induces differential gene expression in the rat cortex. J. Neurochem. 83 (2002) 1043-1053
12. Kozlovsky N., Belmaker R.H., and Agam G. Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients. Am. J. Psychiatry 157 (2000) 831-833
13. Lai M.M., Luo H.R., Burnett P.E., Hong J.J., and Snyder S.H. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. J. Biol. Chem. 275 (2000) 34017-34020
14. Liu J.P., Sim A.T., and Robinson P.J. Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization. Science 265 (1994) 970-973
15. Malenka R.C. Synaptic plasticity in the hippocampus: LTP and LTD. Cell 78 (1994) 535-538
16. Miyakawa T., Leiter L.M., Gerber D.J., Gainetdinov R.R., Sotnikova T.D., Zeng H., Caron M.G., and Tonegawa S. Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 8987-8992 (Electronic publication 2003 Jul 8988)
17. Motulsky H. Intuitive Biostatistics (1995), Oxford university Press, New-York
18. Roberts S.B., Hill C.A., Dean B., Keks N.A., Opeskin K., and Copolov D.L. Confirmation of the diagnosis of schizophrenia after death using DSM-IV: a Victorian experience. Aust. N. Z. J. Psychiatry 32 (1998) 73-76
19. Rusnak F., and Mertz P. Calcineurin: form and function. Physiol. Rev. 80 (2000) 1483-1521
20. Rusnak F., Mertz P., Petter T., and Yu L. Regulation of protein phosphatase calcineurin by redox: implication for catalysis and signal transduction. In: Ferreira G.C., Moura J.J., and Franco R. (Eds). Iron Metabolosm: Inorganic Biochemistry and Regulatory Mechanisms (1999), Wiley-VCH, New-York 275-302
21. Seeman P. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1 (1987) 133-152
22. Steiner J.P., Dawson T.M., Fotuhi M., Glatt C.E., Snowman A.M., Cohen N., and Snyder S.H. High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature 358 (1992) 584-587
23. Sun L., Moonga B.S., Lu M., Zaidi N., Iqbal J., Blair H.C., Epstein S., Abe E., Troen B.R., Huang C.L., and Zaidi M. Molecular cloning, expression, and function of osteoclastic calcineurin A alpha. Am. J. Physiol. Renal. Physiol. 284 (2003) F575-F583 (Electronic publication 2002 Nov 2005)
24. Tsai G., and Coyle J.T. Glutamatergic mechanisms in schizophrenia. Annu. Rev. Pharmacol. Toxicol. 42 (2002) 165-179
25. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry 44 (1987) 660-669
26. Winder D.G., and Sweatt J.D. Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat. Rev. Neurosci. 2 (2001) 461-474
27. Zeng H., Chattarji S., Barbarosie M., Rondi-Reig L., Philpot B.D., Miyakawa T., Bear M.F., and Tonegawa S. Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory. Cell 107 (2001) 617-629