Molecular cloning, expression, and function of osteoclastic calcineurin Aα

American Journal of Physiology - Renal Physiology

Volumn 284, Issue 3 53-3, 2003, Pages

  Sun, Li ^a,b   Moonga, Baljit S ^a,b   Lu, Min ^a,b   Zaidi, Neeha ^a,b   Iqbal, Jameel ^a,b   Blair, Harry C ^c   Epstein, Solomon ^a,b   Abe, Etsuko ^a,b   Troen, Bruce R ^a,b   Huang, Christopher L H ^d   Zaidi, Mone ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Calcium channel; Gene cloning; Osteoclast; Osteoporosis

Indexed keywords

CALCINEURIN; CALCINEURIN A ALPHA; CALCINEURIN A BETA; CALCIUM CHANNEL; CALCIUM ION; CALMODULIN; COMPLEMENTARY DNA; CYCLOSPORIN A; HYBRID PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; TACROLIMUS; UNCLASSIFIED DRUG; UREA;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL COUNT; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

EID: 0037369397     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00084.2002     Document Type: Article

References (50)

1. Abu-Amer Y, Dowdy SF, Ross FP, Clohisy JC, and Teitelbaum SL. TAT fusion proteins containing tyrosine 42-deleted IκBα arrest osteoclastogenesis. J Biol Chem 276: 30499-30503, 2001.
2. 2+ sensing in the regulation of osteoclastic bone resorption. J Cell Biol 142: 1347-1356, 1998.
3. Aramburu J, Rao O, and Klee CB. Calcineurin: from structure to function. Curr Top Cell Regul 36: 237-295, 2000.
4. Awumey EM, Moonga BS, Sodam BR, Koval AP, Adebanjo OA, Kumegawa M, Zaidi M, and Epstein S. Molecular and functional evidence for calcineurin-A alpha and beta isoforms in the osteoclast: novel insights into cyclosporin A action on bone resorption. Biochem Biophys Res Commun 254: 248-252, 1999.
5. 2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J 18: 522-533, 1999.
6. Boyde A, Bianco P, Portigliatti BM, and Ascenzi A. Collagen orientation in compact bone. I. A new method for the determination of the proportion of collagen parallel to the plane of compact bone sections. Metab Bone Dis Relat Res 5: 299-307, 1984.
7. Buchinsky FJ, Ma Y, Mann GN, Rucinski B, Bryer HP, Romero DF, Jee WS, and Epstein S. T lymphocytes play a critical role in the development of cyclosporin A-induced osteopenia. Endocrinology 137: 2278-2285, 1996.
8. Buttini M, Limonta S, Luyten M, and Boddeke H. Distribution of calcineurin A isoenzyme mRNAs in rat thymus and kidney. Histochem J 27: 291-299, 1995.
9. 2+ flux. Cell 83: 463-472, 1995.
10. Chambers TJ, Revell PA, Fuller K, and Athanasou NA. Resorption of bone by isolated rabbit osteoclasts. J Cell Sci 66: 383-399, 1984.
11. Chellaiah MA, Soga N, Swanson S, McAllister S, Alvarez U, Wang D, Dowdy SF, and Hruka KA. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem 275: 11993-12002, 2000.
12. Crabtree GR. Calcium, calcineurin, and the control of transcription. J Biol Chem 276: 2313-2316, 2001.
13. Dempster DW, Murrills RJ, Horbert WR, and Arnett TR. Biological activity of chicken calcitonin: effects on neonatal rat and embryonic chick osteoclasts. J Bone Miner Res 2: 443-448, 1987.
14. Frantz B, Nordby EC, Bren G, Steffan N, Paya CV, Kincaid RL, Tocci MJ, O'Keefe SJ, and O'Neill EA. Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B. EMBO J 13: 861-870, 1994.
15. Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, Estivill X, and de la Luna S. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 9: 1681-1690, 2000.
16. Giri PR, Marietta CA, Higuchi S, and Kincaid RL. Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes. DNA Cell Biol 11: 415-424, 1992.
17. Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, and Crabtree GR. L-Type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 401: 703-708, 1999.
18. Guerini D. Calcineurin: not just a simple protein phosphatase. Biochem Biophys Res Commun 235: 271-275, 1997.
19. Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, and Rao A. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365: 352-355, 1993.
20. Jayaraman T, Brillantes AM, Timerman AP, Fleischer S, Erdjiment-Bromaga H, Tempst P, and Marks AR. FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem 267: 9474-9477, 1992.
21. Kameda T, Mano H, Yamada Y, Takai H, Amizuka N, Kobori M, Izumi N, Kawashima H, Ozawa H, Ikeda K, Kameda Y, and Kumegawa M. Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells. Biochem Biophys Res Commun 245: 419-422, 1998.
22. Klee CB, Crouch TH, and Krinks MH. Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc Natl Acad Sci USA 76: 6270-6273, 1980.
23. 2+-dependent phospholipid- (and membrane-) binding proteins. Biochemistry 27: 6645-6653, 1988.
24. Klee CB, Ren H, and Wang X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 273: 13367-13370, 1998.
25. Kincaid RL, Takayama H, Billingsley ML, and Sitkovsky MV. Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes. Nature 330: 176-178, 1987.
26. Lai MM, Hong JJ, Ruggiero AM, Burnett PE, Slepnev VI, De Camilli P, and Snyder SH. The calcineurin-dynamin 1 complex as a calcium sensor for synaptic vesicle endocytosis. J Biol Chem 274: 25963-25966, 1999.
27. 2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature 377: 75-79, 1995.
28. Liu J, Albers MW, Wandless TJ, Luan S, Alberg DG, Belshaw PJ, Cohen P, MacKintosh C, Klee CB, and Schreiber SL. Inhibition of T cell signaling by immunophilinligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry 31: 3896-3901, 1992.
29. Lu J, McKinsey TA, Nicil RL, and Olson EN. Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Proc Natl Acad Sci USA 97: 4070-4075, 2000.
30. Malgaroli A, Meldolesi J, Zallone AZ, and Teti A. Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitonin. J Biol Chem 264: 14342- 14347, 1989.
31. Moonga BS, Moss DW, Patchell A, and Zaidi M. Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption. J Physiol 429: 29-45, 1990.
32. Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevky SA, and Dowdy SF. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 4: 1449-1452, 1998.
33. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, and O'Neill EA. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692-694, 1992.
34. Pomies P, Frachet P, and Block MR. Control of the alpha 5 beta 1 integrin/fibronectin interaction in vitro by the serine/threonine protein phosphatase calcineurin. Biochemistry 34: 5104-5112, 1995.
35. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoev T, Mickanin C, Baldwin HS, and Glimcher LH. The transcription factor NF-ATc is essential for cardiac valve formation. Nature 392: 186-190, 1998.
36. Sambrook J, Fritsch EF, and Maniatis T. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory: Cold Spring Harbor, NY, 1989.
37. Schreiber SL and Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today 13: 136-142, 1992.
38. Shibasaki F, Price ER, Milan D, and McKeon F. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382: 370-373, 1996.
39. Shibasaki F, Hallin U, and Uchino H. Calcineurin as a multifunctional regulator. J Biochem (Tokyo) 131: 1-15, 2002.
40. Silver IA, Murrills RJ, and Etherington DJ. Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res 175: 266-276, 1988.
41. 2+- and calmodulin-dependent protein phosphatase: probable identity with calcineurin (CaM-BP80). FEBS Lett 137: 80-84, 1982.
42. Sugiura R, Sio SO, Shuntoh H, and Kuno T. Molecular genetic analysis of the calcineurin signaling pathways. Cell Mol Life Sci 58: 278-288, 2001.
43. Sun L, Adebanjo OA, Moonga BS, Corisdeo S, Anandatheerthavarada HK, Biswas G, Arakawa T, Hakeda Y, Koval A, Sodam B, Bevis PJR, Moser AJ, Lai FA, Epatein S, Troen BR, Kumegawa M, and Zaidi M. CD38/ADP-ribosyl; cyclase: a new role in the regulation of osteoclastic bone resorption. J Cell Biol 146: 1161-1171, 1999.
44. Tezuka K, Sato T, Kamioka H, Nijweide PJ, Tanaka K, Matsuo T, Ohta M, Kurihara N, Hakeda Y, and Kumegawa M. Identification of osteopontin in isolated rabbit osteoclasts. Biochem Biophys Res Commun 186: 911-917, 1992.
45. Tsurukai T, Udagawa N, Matsuzaki K, Takahashi N, and Suta T. Roles of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis. J Bone Miner Metab 18: 177-184, 2000.
46. Vocero-Akbani A, Chellaiah MA, Hruska KA, and Dowdy SF. Protein transduction: delivery of Tat-GTPase fusion proteins into mammalian cells. Methods Enzymol 332: 36-49, 2001.
47. Zaidi M, Moonga BS, Moss DW, and MacIntyre I. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochem Biophys Res Commun 159: 68-71, 1989.
48. Zaidi M, Alam AS, Shankar VS, Bax BE, Bax CM, Moomga BS, Bevis PJ, Stevens C, Blake DR, Pazianas M, and Huang C-LH. Cellular biology of bone resorption. Biol Rev Camb Philos Soc 68: 197-264, 1993.
49. 2+ sensing. J Clin Invest 96: 1582-1590, 1995.
50. Zaidi M, Adebanjo OA, Moonga BS, Sun L, and Huang CL. Emerging insights into the role of calcium ions in osteoclast regulation. J Bone Miner Res 14: 669-674, 1999.