Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen

Antiviral Research

Volumn 70, Issue 2, 2006, Pages 39-50

  Gu, Baohua ^a   Ouzunov, Serguey ^a   Wang, Liguan ^a   Mason, Peter ^b   Bourne, Nigel ^b   Cuconati, Andy ^c   Block, Timothy M ^a,c  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c Institute for Hepatitis and Viral Research   (United States)

Author keywords

High throughput screen (HTS); Small molecule inhibitor; West Nile virus

Indexed keywords

1 (4 CYCLOHEXYLBENZENESULFONYL) 3,5 DIMETHYLPIPERIDINE; 101 G7; 124 F3; 18 B3; 18 D2; 18 H5; 182 C2; 2 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID(4 CHLOROPHENYL)AMIDE; 2 H7; 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONIC ACID(2,5 DICHLOROPHENYL)AMIDE; 20 E7; 207 E5; 24 C10; 253 B10; 253 F11; 253 F8; 253 G8; 253 H8; 275 D9; 275 F9; 3 (4 CHLOROBENZENESULFONYL)PROPIONAMIDE; 3,4 DIETHOXY N [2 (4 METHOXYPHENYL) 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL]BENZAMIDE; 309 F6; 310 B3; 331 D11; 331 E11; 4 (PIPERIDINE 1 SULFONYL) N (2 3 TOLYL 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL)BENZAMIDE; 4 BENZYLAMINO 6 ETHOXY QUINOLINE 3 CARBOXYLIC ACID ETHYL ESTER; 4 ISOPROPOXY N [2 (4 METHOXYPHENYL) 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL]BENZAMIDE; 4 ZOLOTRAHYDROTHOPHENE DERIVATIVE; 42 E5; 50 A8; 52 F2; 6 (2 CHLOROBENZYL) 7 HYDROXY 5 METHYLPYRAZOLO[1,5 A]PYRIMIDINE 3 CARBOXYLIC ACID SEC BUTYLAMIDE; 6 (2 CHLOROBENZYL) 7 HYDROXY 5 METHYLPYRAZOLO[1,5 A]PYRIMIDINE 3 CARBOXYLIC ACID(2 CYCLOHEX 1 ENYL ETHYL)AMIDE; 6 (2 FLUOROBENZYL) 7 HYDROXY 5 METHYLPYRAZOLO[1,5 A]PYRIMIDINE 3 CARBOXYLIC ACID(2 4 TOLYL ETHYL)AMIDE; 6 (2 FLUOROBENZYL) 7 HYDROXY 5 METHYLPYRAZOLO[1,5 A]PYRIMIDINE 3 CARBOXYLIC ACID[2 (ETHYLPHENYLAMINO)ETHYL]AMIDE; 6 PHENYL 2 (4,6,8 TRIMETHYLQUINAZOLIN 2 YL) 5,6 DIHYDRO 3H PYRIMIDIN 4 ONE; 63 C10; ANTIVIRUS AGENT; BENZO[1,3]DIOXOLE 5 CARBOXYLIC ACID[2 (4 FLUOROPHENYL) 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL]AMIDE; BENZO[1,3]DIOXOLE 5 CARBOXYLIC ACID[2 (4 METHOXYPHENYL) 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL]AMIDE; CYCLOPROPANECARBOXYLIC ACID[2 (2,4 DIMETHYLPHENYL) 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL]AMIDE; LUCIFERASE; N (3 ETHYLPHENYL) 3 PHENYL 2 (THIOPHENE 2 SULFONYLAMINO)PROPIONAMIDE; N (5 METHYLISOXAZOL 3 YL) 4 (4 4 TOLYLTHIAZOL 2 YLAMINO)BENZENESULFONAMIDE; N [2 (3 CHLOROPHENYL) 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL] 3,5 DIMETHOXYBENZAMIDE; N [2 (4 METHOXYPHENYL) 2,6 DIHYDRO 4H THIENOL[3,4 C]PYRAZOL 3 YL] 4 (PIPERIDINE 1 SULFONYL)BENZAMIDE; N [4 (N HYDROXYCARBAMIMIDOYL)PHENYL] 2 (4 METHOXYPHENYL)ACETAMIDE; N [4 (N HYDROXYCARBAMIMIDOYL)PHENYL] 3 (4 METHOXYPHENYL)PROPIONAMIDE; PYROZOLOPYRIMIDINE DERIVATIVE; THIOPHENE 2 CARBOXYLIC ACID[2 (4 METHOXYPHENYL) 2,6 DIHYDRO 4H THIENO[3,4 C]PYRAZOL 3 YL]AMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOACCUMULATION; BIOASSAY; CELL CULTURE; CELL LINE; CELL STRAIN BHK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPLICON; RNA VIRUS; STRUCTURE ACTIVITY RELATION; VIRUS GENOME; VIRUS INFECTION; VIRUS REPLICATION; WEST NILE FLAVIVIRUS;

ANIMALS; ANTIVIRAL AGENTS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CRICETINAE; DRUG EVALUATION, PRECLINICAL; GENOME, VIRAL; INHIBITORY CONCENTRATION 50; LUCIFERASES; REPLICON; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION; WEST NILE VIRUS;

FLAVIVIRIDAE; INSECTA; MAMMALIA; RNA VIRUSES; WEST NILE VIRUS;

EID: 33646468995     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2006.01.005     Document Type: Article

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