The importance of pathologic complete response in rectal cancer patients treated by preoperative chemoradiotherapy;Preoperatif kemoradyoterapi uygulanan rektum kanserli olgularda patolojik tam yanitin önemi

UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi

Volumn 15, Issue 3, 2005, Pages 120-131

  Ünsal, Diclehan ^a,b   Tunç, Evrim ^a   Menteş, B Bülent ^a   Üner, Aytuǧ ^a   Pak, Yücel ^a  

^a GAZI UNIVERSITY   (Turkey)

^b Genel Cerrahi Anabilim Dali ^*  (Turkey)

Author keywords

Adjuvant treatment; Chemoradiotherapy; Pathologic complete response; Radiotherapy; Rectal cancer

Indexed keywords

ANTINEOPLASTIC AGENT;

ARTICLE; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; HUMAN; METASTASIS; PREOPERATIVE PERIOD; PROGNOSIS; RECTUM CANCER; TREATMENT RESPONSE;

EID: 33646453585     PISSN: 1306133X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. NIH Consensus Conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 264: 1444-1450, 1990.
2. Ünsal D, Akmansu M. Kolorektal kanserlerde adjuvant radyoterapi. Hematoloji Onkoloji Güncel Derleme Dergisi 5: 181-192, 2003.
3. Yildiz F. Rektum kanserlerinde preoperatif adjuvan tedavi. Hematoloji Onkoloji Güncel Derleme Dergisi 6: 99-103, 2004.
4. Minsky BD, Cohen AM, Kemeny N, et al. Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol 10: 79-87, 1992.
5. Chen ET, Mohiuddin M, Brodovsky H, et al. Downstaging of advanced rectal cancer following combined preoperative chemotherapy and high dose radiation. Int J Radiat Oncol Biol Phys 3: 169-175, 1994.
6. Minsky BD, Cohen AM, Enker WE, Paty P. Sphincter preservation with preoperative radiation therapy and coloanal anastomosis. Int J Radiat Oncol Biol Phys 31: 553-559, 1995.
7. Janjan NA, Khoo VS, Abbruzzese J, e al. Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: The M.D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 44: 1027-1038, 1999.
8. Minsky BD, Cohen AM, Enker WE, et al. Preoperative 5-FU, low-dose leucovorin, and radiation tharepy for locally advanced and unresectable rectal cancer. Int J Radiat Oncol Biol Phys 37: 289-295, 1997.
9. Kaminsky-Forrett MC, Conroy T, Luporsi E, et al. Prognostic implications of downstaging following preoperative radiation therapy for operable T3-T4 rectal cancer. Int J Radiat Oncol Biol Phys 42: 935-941, 1998.
10. Chan AK, Wong AO, Langevin J, et al. Preoperative chemotherapy and pelvic radiation for tethered or fixed rectal cancer: A phase II dose escalation study. Int J Radiat Oncol Biol Phys 48: 843-856, 2000.
11. Theodoropoulos G. Wise WE, Padmanabhan A, et al. T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 45: 895-903, 2002.
12. Rich TA, Skibber JM, Ajani J, et al. Preoperative infusional chemoradiation therapy for stage T3 rectal cancer. Int J Radiat Oncol Biol Phys 32: 1025-1029, 1995.
13. Chari RS, Tyler DS, Anscher MS, et al. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum. Ann Surg 221: 778-786, 1995.
14. Grann A, Minsky BD, Cohen AM, et al. Preliminary results of preoperative 5-fluorouracil, low-dose leucovorin and concurrent radiation therapy for clinically resectable T3 rectal cancer. Dis Colon Rectum 40: 515-522, 1997.
15. Valentini V, Coco C, Cellini N, et al. Preoperative chemoradiation for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response and sphincter preservation. Int J Radiat Oncol Biol Phys 40: 1067-1075, 1998.
16. Valentini V, Coco C. Pieciocchi A, et al. Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long term analysis of 165 patients. Int J Radiat Oncol Biol Phys 53: 664-674, 2002.
17. Wheeler JMD, Dodds E, Warren BF, et al. Preoperative chemoradiotherapy and total mesorectal excision surgery for locally advanced rectal cancer: Correlation with rectal cancer regression grade. Dis Colon Rectum 47: 2025-2031, 2004.
18. Glynne-Jones R. Colorectal cancer synchonous preoperative chemoradiation in rectal cancer. Colorectal Cancer 4: 29-35, 2000.
19. American Joint Committee on Cancer. AJCC Cancer Staging Handbook. 6th ed. Philadelphia, Lippincott Raven Publishers, 2002.
20. Garcia-Aguilar J, Pollack J, Lee SH, et al. Endorectal ultrasonography in preoperative staging of rectal tumors. Dis Colon Rectum 45: 10-15, 2002.
21. Adams DR, Blatchford GJ, Lin KM, et al. Use of preoperative ultrasound staging for treatment of rectal cancer. Dis Colon Rectum 42: 159-166, 1999.
22. Pucciarelli S, Toppan P, Friso ML, et al. Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for a better outcome. Dis Colon Rectum 47: 1798-1807, 2004.
23. Chan AKP, Wong A, Jenken D. et al. Posttreatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys 61: 665-677, 2005.
24. Berger C, De Muret A, Garaud P, et al. Preoperative radiotherapy (RT) for rectal cancer: Predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications. Int J Radiat Oncol Biol Phys 37: 619-627, 1997.
25. Bosset JF, Magnin V, Maingon P, et al. Preoperative radiochemotherapy in rectal cancer: Long-term results of a phase II trial. Int J Radiat Oncol Biol Phys 46: 323-327, 2000.
26. Garcia-Aguilar J, Anda EH, Sirivongs OP, et al. A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision. Dis Colon Rectum 46: 298-304, 2003.
27. Kodner IJ, Shemesh EI, Fry RD, et al. Preoperative irradiation for rectal cancer: Improved local control and long-term survival. Ann Surg 209: 194-199, 1989.
28. Janjan NA, Abbruzzese J, Pazdur R, et al. Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer. Radiother Oncol 51: 153-160, 1999.
29. Ahmad NR, Nagle D. Long-term results of preoperative radiation therapy alone for stage T3 and T4 rectal cancer. Br J Surg 84: 1445-1448, 1997.
30. Giralt J, Eraso A, Armengo M, et al. Epidermal growth factor receptor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperative radiotherapy. Int J Radiat Oncol Biol Phys 54: 1460-1465, 2002.
31. Unsal D, Uner A, Akyurek N, et al. MMP-9 expression as a predictor of tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy. Proc Am Soc Clin Oncol 2005;23: abstract 9606.
32. Papillon J, Berard F. Endocavitary irradiation in the conservative treatment of adenocarcinoma of the low rectum. World J Surg 16: 451-457, 1992.
33. Habr-Gama A, de Souza PM, Riberio U Jr, et al. Low rectal cancer: Impact of radiation and chemotherapy on surgical treatment. Dis Colon Rectum 41: 1087-1096, 1998.
34. Mohiuddin M, Regine WF, John WJ, et al. Preoperative chemoradiation in fixed distal rectal cancer: Dose time factors for pathological complete response. Int J Radiat Oncol Biol Phys 46: 883-888, 2000.
35. Janjan NA, Crane CN, Feig BW, et al. Prospective trial of preoperative concomitant boost radiotherapy with continuous 5-fluorouracil for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 47: 713-718, 2000.
36. Myerson RJ, Valentini V, Birbbaum EH, et al. A joint U.S.-Italian phase I/II trial of three dimensionally planned concurrent boost radiotherapy and protracted venous infusion of 5-FU chemotherapy for locally advanced rectal carcinoma: Response to treatment. Int J Radiat Oncol Biol Phys 50: 1299-1308, 2001.
37. Gambacorta MA, Valentini V, Moganti AG, et al. Chemoradiation with raltitrexed (tomudex) in preoperative treatment of stage II-III resectable rectal cancer: A phase II study. Int J Radiat Oncol Biol Phys 60: 130-138, 2004.
38. Uzcudun AE, Batlle JF, Velasco JC, et al. Efficacy of preoperative radiation therapy for resectable rectal adenocarcinoma when combined with oral tegafur-uracil modulated with leucovorin. Dis Colon Rectum 45: 1349-1358, 2002.
39. Mehta VK, Cho C, Ford JM, et al. Phase II trial of preoperative 3D conformal radiotherapy protracted venous infusion 5-fluorouracil, and weekly CPT 11, followed by surgery for ultrasound staged T3 rectal cancer. Int J Radiat Oncol Biol Phys 55: 132-137, 2003.
40. Kim JS, Kim JS, Cho MJ, et al. Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 54: 403-408, 2002.
41. Gambacorta MA, Valentini V, Coco C, et al. Chemoradiation with raltitrexed and oxaliplatin in preoperative treatment of stage II-III resectable rectal cancer: Phase I and II studies. Int J Radiat Oncol Biol Phys 60: 139-148, 2004.