A novel dual antagonist of thromboxane A2 and leukotriene D 4 receptors: Synthesis and structure-activity relationships of chloroquinolylvinyl derivatives

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 5, 2006, Pages 603-610

  Okamoto, Yoshinori ^a   Yokota, Masaki ^a   Kawazoe, Soichiro ^a   Kubota, Hirokazu ^a   Nagaoka, Hitoshi ^a   Arakida, Yasuhito ^a   Takeuchi, Makoto ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Dual antagonist; Leukotriene D4; Structure activity relationship; Thromboxane A2

Indexed keywords

1 [[2 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]METHYLCYCLOPROPYLACETIC ACID; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3 [[2 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]PROPANOIC ACID; 4 [[2 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]3,3 DIMETHYLBUTYLIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO] 3,3 DIMETHYLBUTYLIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO]ACETIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO]BUTYLIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO]ETHYL]BENZOIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO]METHYL] 1 CYCLOPROPANACETIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO]METHYL]BENZOIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO]METHYL]PHENYLACETIC ACID; 4 [[3 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]PROPYL]THIO]PROPIONIC ACID; 4 [[[2 [4 BROMOPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]METHYL]BENZOIC ACID; 4 [[[2 [4 CHLOROPHENYLSULFONYLAMINO] 1 [3 [ 2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]METHYL]BENZOIC ACID; 4 [[[2 [4 FLUOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]METHYL]BENZOIC ACID; 4 [[[2 [4 NITROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]METHYL]BENZOIC ACID; 4 [[[2 [4CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]2 ETHYL]BENZOIC ACID; 4 [[[2 [4CHLOROPHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]METHYL]PHENYLACETIC ACID; 4 [[[2 [PHENYLSULFONYLAMINO] 1 [3 [2 (7 CHLORO 2 QUINOLYL)VINYL]PHENYL]ETHYL]THIO]METHYL]BENZOIC ACID; CHLOROQUINOLYLVINYL DERIVATIVE; DALTROBAN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; IC 50; THROMBOCYTE AGGREGATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; AIRWAY RESISTANCE; ANIMALS; CAPILLARY PERMEABILITY; CHLOROQUINOLINOLS; GUINEA PIGS; ILEUM; INDICATORS AND REAGENTS; MALE; MEMBRANE PROTEINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RECEPTORS, LEUKOTRIENE; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; VINYL COMPOUNDS;

EID: 33646433452     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.603     Document Type: Article

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