In vivo pharmacologic profile of YM158, a new dual antagonist for leukotriene D4 and thromboxane A2 receptors

Japanese Journal of Pharmacology

Volumn 83, Issue 1, 2000, Pages 63-72

  Arakida, Yasuhito ^a   Ohga, Keiko ^a   Suwa, Kiyomi ^a   Okada, Yohei ^a   Morio, Hiroki ^a   Yokota, Masaki ^a   Miyata, Keiji ^a   Yamada, Toshimitsu ^a   Honda, Kazuo ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Asthma; Leukotriene D4; Receptor antagonist; Thromboxane A2; YM158

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; LEUKOTRIENE D4 RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PRANLUKAST; THROMBOXANE A2 RECEPTOR; ZAFIRLUKAST;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ARTICLE; BRONCHOSPASM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; GUINEA PIG; IN VIVO STUDY; MALE; NONHUMAN;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; AIRWAY RESISTANCE; ANIMALS; ANTI-ASTHMATIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE D4; MALE; RECEPTORS, THROMBOXANE; TETRAZOLES; THIAZOLES;

EID: 0034036545     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.83.63     Document Type: Article

References (38)

1. Samuelsson B: Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220, 568-575 (1983)
2. Henderson WR Jr: Eicosanoids and platelet-activating factor in allergic respiratory diseases. Am Rev Respir Dis 143, S86-S90 (1991)
3. Kaneko S, Ueda N, Tonai T, Maruyama T, Yoshimoto T and Yamamoto S: Arachidonate 5-lipoxygenase of porcine leukocytes studied by enzyme immunoassay using monoclonal antibodies. J Biol Chem 262, 6741-6745 (1987)
4. 4 in humans. Am Rev Respir Dis 141, 1441-1445 (1990)
5. 4, and histamine in asthmatics. Am Rev Respir Dis 146, 96-103 (1992)
6. 4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis 142, 112-119 (1990)
7. 2 biosynthesis in acute asthma and after antigen challenge. Am Rev Respir Dis 143, 119-125 (1991)
8. Busse WW: The role of leukotrienes in asthma and allergic rhinitis. Clin Exp Allergy 26, 868-879 (1996)
9. Nakagawa N, Obata T, Kobayashi T, Okada Y, Nambu F, Terawaki T and Aishita H: In vivo pharmacologic profile of ONO-1078: A potent, selective and orally active peptide leukotriene (LT) antagonist. Jpn J Pharmacol 60, 217-225 (1992)
10. Taniguchi Y, Tamura G, Honma M, Aizawa T, Maruyama N, Shirato K and Takishima T: The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects. J Allergy Clin Immunol 92, 507-512 (1993)
11. Krell RD, Aharony D, Buckner CK, Keith RA, Kusner EJ, Snyder DW, Bernstein PR, Matassa VG, Yee YK, Brown FJ, Hesp B and Giles RE: The preclinical pharmacology of ICI 204,219: A peptide leukotriene antagonist. Am Rev Respir Dis 141, 978-987 (1990)
12. Dahlén B, Zatterström O, Björck T and Dahlén SE: The leukotriene-amagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. Eur Respir J 7, 324-331 (1994)
13. 4 receptor antagonist, in subjects with bronchial asthma. J Respir Crit Care Med 150, 618-623 (1994)
14. Ashida Y, Matsumoto T, Kuriki H, Shiraishi M, Kato K and Terao S: A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38, 91-112 (1989)
15. 2 receptor antagonist (AA-2414) on bronchial hyperresponsiveness to methacholine in subjects with asthma. J Allergy Clin Immunol 87, 23-27 (1991)
16. 2 synthetase inhibitor (OKY-046) improves abnormal mucociliary transport in asthmatic patients. Ann Allergy 68, 53-56 (1992)
17. Dahlén SE, Hedqvist P, Hammarström S and Samuelsson B: Leukotrienes are potent constrictors of human bronchi. Nature 288, 484-486 (1980)
18. 4 in guinea pigs. Prostaglandins 23, 865-880 (1982)
19. 4 on the microvasculature of guinea-pig skin. Prostaglandins 21, 315-321 (1981)
20. Rinkema LE, Bemis KG and Fleisch JH: Production and antagonism of cutaneous vascular permeability in the guinea pig in response to histamine, leukotrienes and A23187. J Pharmacol Exp Ther 230, 550-557 (1984)
21. 4 increase the release of mucus from human airways in vitro. Am Rev Respir Dis 126, 449-451 (1982)
22. Jones GL, Saroea HG, Watson RM and O'byrne PM: Effect of an inhaled thromboxane mimetic (U46619) on airway function in human subjects. Am Rev Respir Dis 145, 1270-1274 (1992)
23. Minoguchi K, Adachi M, Kobayashi T and Takahashi T: The mechanism of airway hyperresponsiveness following immediate asthmatic response in ovalbumin-sensitized guinea-pigs. J Lipid Mediators 5, 169-172 (1992)
24. 2 inhibitors in guinea pigs. Biol Pharm Bull 16, 1099-1103 (1993)
25. 2 receptor antagonist, on U-46619-induced contraction of guinea pig and human tracheal strips in vitro and on bronchoconstriction in guinea pigs in vivo. Prostaglandins 41, 375-382 (1991)
26. 2-induced bronchoconstriction in the guinea-pig. Br J Pharmacol 104, 596-602 (1991)
27. 2 receptors. J Pharmacol Exp Ther 287, 633-639 (1998)
28. 2 and peptidoleukotrienes. Abst Pap Am Chem Soc 213 Meeting, 2, MEDI 075 (1997)
29. 4 receptor antagonist. Can J Pharmacol 73, 191-201 (1995)
30. Obata T, Okada Y, Motoishi M, Nakagawa N, Terawaki T and Aishita H: In vitro antagonism of ONO-1078, a newly developed anti-asthmatic agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol 60, 227-237 (1992)
31. 2 receptor antagonistic activity of phenol derivatives. J Med Chem 35, 2202-2209 (1992)
32. Anderson P and Bergstrand H: Antigen-induced bronchial anaphylaxis in actively sensitized guinea-pigs: Effect of long-term treatment with sodium cromoglycate and aminophylline. Br J Pharmacol 74, 601-609 (1981)
33. Levine BB, Chang H Jr and Vaz NM: The production of haptenspecific reaginic antibodies in the guinea pig. J Immunol 106, 29-33 (1971)
34. Arakida Y, Ohga K, Suwa K, Yokota M, Miyata K, Yamada T and Honda K: Effects of lipid mediator antagonists on predominant mediator controlled asthmatic reactions in passively sensitized guinea pigs. J Pharmacol Exp Ther 290, 1285-1291 (1999)
35. 4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. Prostaglandins Leukot Essent Fatty Acids 55, 437-440 (1996)
36. Arakawa HL, Pötvall J, Kawikova I, Löfdahl CG and Skoogh BE: Leukotriene D4-and prostaglandin F2α-induced airflow obstruction and airway plasma exudation in guinea-pig: role of thromboxane and its receptor. Br J Pharmacol 110, 127-132 (1993)
37. Sakurai T, Yamaguchi S, Iwama T and Nagai H: Pharmacological studies of platelet-activating factor (PAF)-induced augmentation of response to histamine in guinea-pigs. Prostaglandins Leukot Essent Fatty Acids 51, 95-99 (1994)
38. 2 receptor antagonists after porcine carotid bypass. Cardiovasc Surg 5, 92-98 (1997)