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Volumn 14, Issue 5, 2000, Pages 501-514

Review article: The clinical role of anti-TNFα antibody treatment in Crohn's disease

Author keywords

[No Author keywords available]

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; AUTACOID; AUTOANTIBODY; AZATHIOPRINE; CYCLOSPORIN; DNA ANTIBODY; ETANERCEPT; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PENTOXIFYLLINE; PREDNISOLONE; STEROID; TACROLIMUS; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 0034062016     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2000.00777.x     Document Type: Review
Times cited : (67)

References (84)
  • 1
    • 0026418194 scopus 로고
    • Humanized antibodies for therapy
    • 1 Co MS, Queen C. Humanized antibodies for therapy. Nature 1991; 351: 501-2.
    • (1991) Nature , vol.351 , pp. 501-502
    • Co, M.S.1    Queen, C.2
  • 3
    • 0025904206 scopus 로고
    • Anti-Tac-H, a humanized antibody to the interleukin-2 receptor, prolongs primate cardiac allograft survival
    • 3 Brown PSJ, Parenteau GL, Dirbas FM, et al. Anti-Tac-H, a humanized antibody to the interleukin-2 receptor, prolongs primate cardiac allograft survival. Proc Natl Acad Sci USA 1991; 88: 2663-7.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2663-2667
    • Brown, P.S.J.1    Parenteau, G.L.2    Dirbas, F.M.3
  • 4
    • 0027361432 scopus 로고
    • Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
    • 4 Knight DM, Trinh H, Le J, et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 1993; 30: 1443-53.
    • (1993) Mol Immunol , vol.30 , pp. 1443-1453
    • Knight, D.M.1    Trinh, H.2    Le, J.3
  • 5
    • 0029004771 scopus 로고
    • Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions
    • 5 Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J. Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions. Cytokine 1995; 7: 251-9.
    • (1995) Cytokine , vol.7 , pp. 251-259
    • Scallon, B.J.1    Moore, M.A.2    Trinh, H.3    Knight, D.M.4    Ghrayeb, J.5
  • 6
    • 0000062952 scopus 로고    scopus 로고
    • Infliximab treatment benefits correlate with pharmacodynamic parameters in Crohn's disease patients
    • 6 Wagner C, Mace K, deWoody K, et al. Infliximab treatment benefits correlate with pharmacodynamic parameters in Crohn's disease patients. Digestion 1998; 59(Suppl. 3): 124-5.
    • (1998) Digestion , vol.59 , Issue.SUPPL. 3 , pp. 124-125
    • Wagner, C.1    Mace, K.2    DeWoody, K.3
  • 7
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
    • 7 Baert FJ, D'Haens GR, Peeters M, et al. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 1999; 116: 22-8.
    • (1999) Gastroenterology , vol.116 , pp. 22-28
    • Baert, F.J.1    D'Haens, G.R.2    Peeters, M.3
  • 8
    • 0031573593 scopus 로고    scopus 로고
    • A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease
    • 8 Plevy SE, Landers CJ, Prehn J, et al. A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J Immunol 1997; 159: 6276-82.
    • (1997) J Immunol , vol.159 , pp. 6276-6282
    • Plevy, S.E.1    Landers, C.J.2    Prehn, J.3
  • 9
    • 3543058090 scopus 로고    scopus 로고
    • Beneficial effect of treatment with a monoclonal anti-tumor necrosis factor-alpha antibody on markers of coagulation and fibrinolysis in patients with active Crohn's disease
    • 9 Hommes DW, van Dullemen HM, van der Levi MEA, Woody J, Tytgat GN, et al. Beneficial effect of treatment with a monoclonal anti-tumor necrosis factor-alpha antibody on markers of coagulation and fibrinolysis in patients with active Crohn's disease. Haemostasis 1998; 27: 269-77.
    • (1998) Haemostasis , vol.27 , pp. 269-277
    • Hommes, D.W.1    Van Dullemen, H.M.2    Van Der Levi, M.E.A.3    Woody, J.4    Tytgat, G.N.5
  • 10
    • 0029671297 scopus 로고    scopus 로고
    • In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis. Short term cellular and molecular effects
    • 10 Lorenz HM, Antoni C, Valerius T, et al. In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis. Short term cellular and molecular effects. J Immunol 1996; 156: 1646-53.
    • (1996) J Immunol , vol.156 , pp. 1646-1653
    • Lorenz, H.M.1    Antoni, C.2    Valerius, T.3
  • 11
    • 0030680171 scopus 로고    scopus 로고
    • Target effector role of vascular endothelium in the inflammatory response: Insights from the clinical trial of anti-TNF alpha antibody in rheumatoid arthritis
    • 11 Paleolog E. Target effector role of vascular endothelium in the inflammatory response: insights from the clinical trial of anti-TNF alpha antibody in rheumatoid arthritis. Mol Pathol 1997; 50: 225-33.
    • (1997) Mol Pathol , vol.50 , pp. 225-233
    • Paleolog, E.1
  • 12
    • 0030750272 scopus 로고    scopus 로고
    • Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy
    • 12 Brennan FM, Browne KA, Green PA, Jaspar JM, Maini RN, Feldmann M. Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy. Br J Rheumatol 1997; 36: 643-50.
    • (1997) Br J Rheumatol , vol.36 , pp. 643-650
    • Brennan, F.M.1    Browne, K.A.2    Green, P.A.3    Jaspar, J.M.4    Maini, R.N.5    Feldmann, M.6
  • 13
    • 0032522666 scopus 로고    scopus 로고
    • A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production
    • 13 Pender SL, Fell JM, Chamow SM, Ashkenazi A, MacDonald TT. A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production. J Immunol 1998; 160: 4098-103.
    • (1998) J Immunol , vol.160 , pp. 4098-4103
    • Pender, S.L.1    Fell, J.M.2    Chamow, S.M.3    Ashkenazi, A.4    MacDonald, T.T.5
  • 14
    • 0000288406 scopus 로고    scopus 로고
    • Anti-TNF antibody cA2 induces apoptosis in CD3/CD28 stimulated Jurkat cells: A potent immunomodulating mechanism
    • Abstract
    • 14 Hove T, van Deventer SJH. Anti-TNF antibody cA2 induces apoptosis in CD3/CD28 stimulated Jurkat cells: a potent immunomodulating mechanism. Gastroenterology 1999; 116: A739(Abstract).
    • (1999) Gastroenterology , vol.116
    • Hove, T.1    Van Deventer, S.J.H.2
  • 15
    • 85047676748 scopus 로고    scopus 로고
    • Chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
    • 15 Targan S, Schaible T. Chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. N Engl J Med 1998; 338: 333-4.
    • (1998) N Engl J Med , vol.338 , pp. 333-334
    • Targan, S.1    Schaible, T.2
  • 16
    • 0033125226 scopus 로고    scopus 로고
    • Antitumor necrosis factor therapy for inflammatory bowel disease: A review of agents, pharmacology, clinical results, and safety
    • 16 Sandborn WJ, Hanauer SB. Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety. Inflamm Bowel Dis 1999; 5: 119-33.
    • (1999) Inflamm Bowel Dis , vol.5 , pp. 119-133
    • Sandborn, W.J.1    Hanauer, S.B.2
  • 17
    • 0029853846 scopus 로고    scopus 로고
    • Endogenous modulators of TNF and IL-1 response are under partial control of TNF in baboon bacteremia
    • 17 Redl H, Schlag G. Paul E, et al. Endogenous modulators of TNF and IL-1 response are under partial control of TNF in baboon bacteremia. Am J Physiol 1996; 271: R1193-8.
    • (1996) Am J Physiol , vol.271
    • Redl, H.1    Schlag, G.2    Paul, E.3
  • 18
    • 0028153998 scopus 로고
    • Differential effect of isotype on efficacy of anti-tumor necrosis factor alpha chimeric antibodies in experimental septic shock
    • 18 Suitters AJ, Foulkes R, Opal SM, et al. Differential effect of isotype on efficacy of anti-tumor necrosis factor alpha chimeric antibodies in experimental septic shock. J Exp Med 1994; 179: 849-56.
    • (1994) J Exp Med , vol.179 , pp. 849-856
    • Suitters, A.J.1    Foulkes, R.2    Opal, S.M.3
  • 19
    • 0031043778 scopus 로고    scopus 로고
    • Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease
    • 19 Stack WA, Mann SD, Roy AJ, et al. Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease [see comments]. Lancet 1997; 349: 521-4.
    • (1997) Lancet , vol.349 , pp. 521-524
    • Stack, W.A.1    Mann, S.D.2    Roy, A.J.3
  • 20
    • 0001349673 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, multi-centre trial of the engineered human antibody to TNF (CDP571) for the induction and maintenance of clinical improvement in patients with moderate to severely active Crohn's disease
    • Abstract
    • 20 Sandborn WJ, Targan S, Wolf SB, et al. A randomized, double-blind, placebo-controlled, multi-centre trial of the engineered human antibody to TNF (CDP571) for the induction and maintenance of clinical improvement in patients with moderate to severely active Crohn's disease. Gut 1999; 4(Suppl. V): A133(Abstract).
    • (1999) Gut , vol.4 , Issue.SUPPL. V
    • Sandborn, W.J.1    Targan, S.2    Wolf, S.B.3
  • 21
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
    • 21 van Dullemen HM, van Deventer SJ, Hommes DW, et al. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 1995; 109: 129-35.
    • (1995) Gastroenterology , vol.109 , pp. 129-135
    • Van Dullemen, H.M.1    Van Deventer, S.J.2    Hommes, D.W.3
  • 22
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
    • Crohn's Disease cA2 Study Group
    • 22 Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997; 337: 1029-35.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    Van Deventer, S.J.3
  • 23
    • 0032833517 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (Infliximab) to maintain remission in Crohn's disease
    • 23 Rutgeerts P, D'Haens G, Targan S, et al. Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (Infliximab) to maintain remission in Crohn's disease [in process citation]. Gastroenterology 1999; 117: 761-9.
    • (1999) Gastroenterology , vol.117 , pp. 761-769
    • Rutgeerts, P.1    D'Haens, G.2    Targan, S.3
  • 24
    • 0003118148 scopus 로고    scopus 로고
    • Magnitude of response to remicade correlates with marker antibody expression
    • Abstract
    • 24 Kam L, Vasiliauskas EA, Landers CJ, Targan S. magnitude of response to remicade correlates with marker antibody expression. Gastroenterology 1999; 116: A744(Abstract).
    • (1999) Gastroenterology , vol.116
    • Kam, L.1    Vasiliauskas, E.A.2    Landers, C.J.3    Targan, S.4
  • 25
    • 0032913394 scopus 로고    scopus 로고
    • Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
    • 25 D'Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial. Gastroenterology 1999; 116: 1029-34.
    • (1999) Gastroenterology , vol.116 , pp. 1029-1034
    • D'Haens, G.1    Van Deventer, S.2    Van Hogezand, R.3
  • 27
    • 0027160429 scopus 로고
    • Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporin A
    • 27 Hanauer SB, Smith MB. Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporin A [see comments]. Am J Gastroenterol 1993; 88: 646-9.
    • (1993) Am J Gastroenterol , vol.88 , pp. 646-649
    • Hanauer, S.B.1    Smith, M.B.2
  • 28
    • 0030968698 scopus 로고    scopus 로고
    • Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease
    • 28 Sandborn WJ. Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. Am J Gastroenterol 1997; 92: 876-9.
    • (1997) Am J Gastroenterol , vol.92 , pp. 876-879
    • Sandborn, W.J.1
  • 30
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • 30 Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340: 1398-405.
    • (1999) N Engl J Med , vol.340 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 31
    • 4243242986 scopus 로고    scopus 로고
    • Repeated infusions of anti TNF alpha chimeric antibody (cA2) maintain remission in refractory Crohn's disease
    • Abstract
    • 31 D'Haens G, Rutgeerts PJ, van Deventer SJH, et al. Repeated infusions of anti TNF alpha chimeric antibody (cA2) maintain remission in refractory Crohn's disease. Gut 1997; 41(Suppl. 3): A68-A69(Abstract).
    • (1997) Gut , vol.41 , Issue.SUPPL. 3
    • D'Haens, G.1    Rutgeerts, P.J.2    Van Deventer, S.J.H.3
  • 32
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • 32 Maini RN, Breedveld FC, Kalden JR, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis [see comments]. Arthritis Rheum 1998; 41: 1552-63.
    • (1998) Arthritis Rheum , vol.41 , pp. 1552-1563
    • Maini, R.N.1    Breedveld, F.C.2    Kalden, J.R.3
  • 33
    • 0033021497 scopus 로고    scopus 로고
    • Anti-TNF strategies in Crohn's disease: Mechanisms, clinical effects, indications
    • 33 Baert FJ, Rutgeerts PR. Anti-TNF strategies in Crohn's disease: mechanisms, clinical effects, indications. Int J Colorectal Dis 1999; 14: 47-51.
    • (1999) Int J Colorectal Dis , vol.14 , pp. 47-51
    • Baert, F.J.1    Rutgeerts, P.R.2
  • 34
    • 0000200979 scopus 로고    scopus 로고
    • Delayed hypersenstivity to Infliximab (Remicade) re-infusion after a 2-4 year interval without treatment
    • Abstract
    • 34 Hanauer SB, Rutgeerts P, D'Haens G, et al. Delayed hypersenstivity to Infliximab (Remicade) re-infusion after a 2-4 year interval without treatment. Gastroenterology 1999; 116: A731(Abstract).
    • (1999) Gastroenterology , vol.116
    • Hanauer, S.B.1    Rutgeerts, P.2    D'Haens, G.3
  • 35
    • 85088602629 scopus 로고    scopus 로고
    • Do infliximab and methotrexate act synergistically in the treatment of rheumatoid arthritis? Comment on the article by Maini et al
    • 35 Rezaian MM. Do infliximab and methotrexate act synergistically in the treatment of rheumatoid arthritis? Comment on the article by Maini et al. [letter]. Arthritis Rheum 1999; 42: 1779-81.
    • (1999) Arthritis Rheum , vol.42 , pp. 1779-1781
    • Rezaian, M.M.1
  • 37
    • 0026565590 scopus 로고
    • Lymphoma in inflammatory bowel disease
    • 37 Greenstein AJ, Mullin GE, Strauchen JA, et al. Lymphoma in inflammatory bowel disease. Cancer 1992; 69: 1119-23.
    • (1992) Cancer , vol.69 , pp. 1119-1123
    • Greenstein, A.J.1    Mullin, G.E.2    Strauchen, J.A.3
  • 38
    • 0022410723 scopus 로고
    • Extraintestinal cancers in inflammatory bowel disease
    • 38 Greenstein AJ, Gennuso R, Sachar DB, et al. Extraintestinal cancers in inflammatory bowel disease. Cancer 1985; 56: 2914-21.
    • (1985) Cancer , vol.56 , pp. 2914-2921
    • Greenstein, A.J.1    Gennuso, R.2    Sachar, D.B.3
  • 40
    • 4243775835 scopus 로고    scopus 로고
    • Diagnoses of extraintestinal manifestations and cancers in IBD in large population based databases
    • Abstract
    • 40 Bernstein CN, Kliewer E, Rawsthorne P, Doig W, Balnchard JF. Diagnoses of extraintestinal manifestations and cancers in IBD in large population based databases. Gastroenterology 1998; 114: A930(Abstract).
    • (1998) Gastroenterology , vol.114
    • Bernstein, C.N.1    Kliewer, E.2    Rawsthorne, P.3    Doig, W.4    Balnchard, J.F.5
  • 41
    • 4243535326 scopus 로고    scopus 로고
    • The incidence of non-Hodgkin's lymphoma in hospitalised Crohn's disease patients in Virginia - An administrative database study
    • Abstract
    • 41 Arseneau KO, Stukenborg GJ, Connors AF, Cominelli F. The incidence of non-Hodgkin's lymphoma in hospitalised Crohn's disease patients in Virginia - an administrative database study. Gastroenterology 1999; 116: A664(Abstract).
    • (1999) Gastroenterology , vol.116
    • Arseneau, K.O.1    Stukenborg, G.J.2    Connors, A.F.3    Cominelli, F.4
  • 44
    • 0028790186 scopus 로고
    • A controlled double blind study of azathioprine in the management of Crohn's disease
    • 44 Candy S, Wright J, Gerber M, Adams G, Gerig M, Goodman R. A controlled double blind study of azathioprine in the management of Crohn's disease. Gut 1995; 37: 674-8.
    • (1995) Gut , vol.37 , pp. 674-678
    • Candy, S.1    Wright, J.2    Gerber, M.3    Adams, G.4    Gerig, M.5    Goodman, R.6
  • 45
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis
    • 45 Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med 1995; 123: 132-42.
    • (1995) Ann Intern Med , vol.123 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3    Sutherland, L.R.4
  • 46
    • 0015220432 scopus 로고
    • Controlled trial of azathioprine in Crohn's disease
    • 46 Rhodes J, Bainton D, Beck P, Campbell H. Controlled trial of azathioprine in Crohn's disease. Lancet 1971; 2: 1273-6.
    • (1971) Lancet , vol.2 , pp. 1273-1276
    • Rhodes, J.1    Bainton, D.2    Beck, P.3    Campbell, H.4
  • 47
    • 0018290191 scopus 로고
    • National Cooperative Crohn's Disease Study: Results of drug treatment
    • 47 Summers RW, Switz DM, Sessions JT Jr. et al. National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology 1979; 77: 847-69.
    • (1979) Gastroenterology , vol.77 , pp. 847-869
    • Summers, R.W.1    Switz, D.M.2    Sessions J.T., Jr.3
  • 48
    • 0037717938 scopus 로고    scopus 로고
    • Azathioprine: State of the art in inflammatory bowel disease
    • 48 Sandborn WJ. Azathioprine: state of the art in inflammatory bowel disease. Scand J Gastroenterol Suppl 1998; 225: 92-9.
    • (1998) Scand J Gastroenterol Suppl , vol.225 , pp. 92-99
    • Sandborn, W.J.1
  • 49
    • 0030041584 scopus 로고    scopus 로고
    • Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
    • 49 Bouhnik Y, Lemann M, Mary JY, et al. Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine [see comments]. Lancet 1996; 347: 215-9.
    • (1996) Lancet , vol.347 , pp. 215-219
    • Bouhnik, Y.1    Lemann, M.2    Mary, J.Y.3
  • 50
    • 0030888894 scopus 로고    scopus 로고
    • Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease
    • 50 D'Haens G, Geboes K, Ponette E, Penninckx F, Rutgeerts P. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease [see comments]. Gastroenterology 1997; 112: 1475-81.
    • (1997) Gastroenterology , vol.112 , pp. 1475-1481
    • D'Haens, G.1    Geboes, K.2    Ponette, E.3    Penninckx, F.4    Rutgeerts, P.5
  • 51
    • 0000653571 scopus 로고    scopus 로고
    • Dose raising of azathioprine beyond 2.5 mg/kg/day in Crohn's disease patients who fail to improve with a standard dose
    • Abstract
    • 51 Barbe L, Marteau P, Lemann M, et al. Dose raising of azathioprine beyond 2.5 mg/kg/day in Crohn's disease patients who fail to improve with a standard dose. Gastroenterology 1998; 114: A925(Abstract).
    • (1998) Gastroenterology , vol.114
    • Barbe, L.1    Marteau, P.2    Lemann, M.3
  • 52
    • 0027164795 scopus 로고
    • Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years experience
    • 52 Connell WR, Kamm MA, Ritchie JK, Lennard-Jones JE. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years experience. Gut 1993; 34: 1081-5.
    • (1993) Gut , vol.34 , pp. 1081-1085
    • Connell, W.R.1    Kamm, M.A.2    Ritchie, J.K.3    Lennard-Jones, J.E.4
  • 53
    • 0015840007 scopus 로고
    • Risk of cancer in renal-transplant recipients
    • 53 Hoover R, Fraumeni JF Jr. Risk of cancer in renal-transplant recipients. Lancet 1973; 2: 55-7.
    • (1973) Lancet , vol.2 , pp. 55-57
    • Hoover, R.1    Fraumeni J.F., Jr.2
  • 54
    • 0028147042 scopus 로고
    • Reversible lymphoma in the setting of azathioprine therapy for Crohn's disease
    • 54 Larvol L, Soule JC, Le Tourneau A. Reversible lymphoma in the setting of azathioprine therapy for Crohn's disease [letter]. N Engl J Med 1994; 331: 883-4.
    • (1994) N Engl J Med , vol.331 , pp. 883-884
    • Larvol, L.1    Soule, J.C.2    Le Tourneau, A.3
  • 56
    • 0028899859 scopus 로고
    • Methotrexate for the treatment of Crohn's disease
    • The North American Crohn's Study Group Investigators [see comments]
    • 56 Feagan BG, Rochon J, Fedorak RN, et al. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators [see comments]. N Engl J Med 1995; 332: 292-7.
    • (1995) N Engl J Med , vol.332 , pp. 292-297
    • Feagan, B.G.1    Rochon, J.2    Fedorak, R.N.3
  • 57
    • 0030069646 scopus 로고    scopus 로고
    • Methotrexate for inflammatory bowel disease: Pharmacology and preliminary results
    • 57 Egan LJ, Sandborn WJ. Methotrexate for inflammatory bowel disease: pharmacology and preliminary results [see comments]. Mayo Clin Proc 1996; 71: 69-80.
    • (1996) Mayo Clin Proc , vol.71 , pp. 69-80
    • Egan, L.J.1    Sandborn, W.J.2
  • 58
    • 0028283781 scopus 로고
    • Methotrexate: Adverse reactions and major toxicities
    • 58 Goodman TA, Polisson RP. Methotrexate: adverse reactions and major toxicities. Rheum Dis Clin North Am 1994; 20: 513-28.
    • (1994) Rheum Dis Clin North Am , vol.20 , pp. 513-528
    • Goodman, T.A.1    Polisson, R.P.2
  • 60
    • 0028362206 scopus 로고
    • Low-dose cyclosporine for the treatment of Crohn's disease
    • The Canadian Crohn's Relapse Prevention Trial Investigators [see comments]
    • 60 Feagan BG, McDonald JW, Rochon J, et al. Low-dose cyclosporine for the treatment of Crohn's disease. The Canadian Crohn's Relapse Prevention Trial Investigators [see comments]. N Engl J Med 1994; 330: 1846-51.
    • (1994) N Engl J Med , vol.330 , pp. 1846-1851
    • Feagan, B.G.1    McDonald, J.W.2    Rochon, J.3
  • 61
    • 0024951546 scopus 로고
    • Cyclosporin for the treatment of severe inflammatory bowel disease
    • published erratum appears in Aliment Pharmacol Ther 1989; 3: 414
    • 61 Baker K, Jewell DP. Cyclosporin for the treatment of severe inflammatory bowel disease [published erratum appears in Aliment Pharmacol Ther 1989; 3: 414]. Aliment Pharmacol Ther 1989; 3: 143-9.
    • (1989) Aliment Pharmacol Ther , vol.3 , pp. 143-149
    • Baker, K.1    Jewell, D.P.2
  • 63
    • 0024955965 scopus 로고
    • Low-dose cyclosporin for Crohn's disease: Implications for clinical trials
    • 63 Brynskov J, Binder V, Riis P, et al. Low-dose cyclosporin for Crohn's disease: implications for clinical trials [see comments]. Aliment Pharmacol Ther 1989; 3: 135-42.
    • (1989) Aliment Pharmacol Ther , vol.3 , pp. 135-142
    • Brynskov, J.1    Binder, V.2    Riis, P.3
  • 64
    • 0025834538 scopus 로고
    • Final report on a placebo-controlled, double-blind, randomized, multicentre trial of cyclosporin treatment in active chronic Crohn's disease
    • 64 Brynskov J, Freund L, Norby RS, et al. Final report on a placebo-controlled, double-blind, randomized, multicentre trial of cyclosporin treatment in active chronic Crohn's disease. Scand J Gastroenterol 1991; 26: 689-95.
    • (1991) Scand J Gastroenterol , vol.26 , pp. 689-695
    • Brynskov, J.1    Freund, L.2    Norby, R.S.3
  • 65
    • 0026694617 scopus 로고
    • Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases
    • International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases [see comments]
    • 65 Feutren G, Mihatsch MJ. Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases [see comments]. N Engl J Med 1992; 326: 1654-60.
    • (1992) N Engl J Med , vol.326 , pp. 1654-1660
    • Feutren, G.1    Mihatsch, M.J.2
  • 66
    • 0021207685 scopus 로고
    • Cyclosporin and steroids in renal transplantation: Risk of Pneumocystis carinii pneumonia?
    • 66 Ballardie FW, Winearls CG, Williams G. Cyclosporin and steroids in renal transplantation: risk of Pneumocystis carinii pneumonia? [Letter]. Lancet 1984; 2: 638-9.
    • (1984) Lancet , vol.2 , pp. 638-639
    • Ballardie, F.W.1    Winearls, C.G.2    Williams, G.3
  • 67
    • 0022430651 scopus 로고
    • Cyclosporin A and Pneumocystis pneumonia
    • 67 Markus MB. Cyclosporin A and Pneumocystis pneumonia [letter]. Med J Aust 1985; 143(2): 91.
    • (1985) Med J Aust , vol.143 , Issue.2 , pp. 91
    • Markus, M.B.1
  • 68
    • 0023794574 scopus 로고
    • Open study of cyclosporin A in patients with severe Crohn's disease refractory to conventional therapy
    • 68 Peltekian KM, Williams CN, MacDonald AS, et al. Open study of cyclosporin A in patients with severe Crohn's disease refractory to conventional therapy. Can J Gastroenterol 1988; 2: 5-11.
    • (1988) Can J Gastroenterol , vol.2 , pp. 5-11
    • Peltekian, K.M.1    Williams, C.N.2    MacDonald, A.S.3
  • 69
    • 0028292007 scopus 로고
    • Cyclosporine in severe ulcerative colitis refractory to steroid therapy
    • 69 Lichtiger S, Present DH, Kornbluth A, et al. Cyclosporine in severe ulcerative colitis refractory to steroid therapy [see comments]. N Engl J Med 1994; 330: 1841-5.
    • (1994) N Engl J Med , vol.330 , pp. 1841-1845
    • Lichtiger, S.1    Present, D.H.2    Kornbluth, A.3
  • 70
    • 0028197044 scopus 로고
    • Efficacy of cyclosporine in treatment of fistula of Crohn's disease
    • 70 Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig Dis Sci 1994; 39: 374-80.
    • (1994) Dig Dis Sci , vol.39 , pp. 374-380
    • Present, D.H.1    Lichtiger, S.2
  • 71
    • 4243658039 scopus 로고    scopus 로고
    • Mycophenolate mofetil inhibits growth and expression of extracellular matrix in human intestinal and rat colonic smooth muscle cells
    • Abstract
    • 71 Zeeh JM, Riley NE, Hoffmann P, Goebell H, Gerken G. Mycophenolate mofetil inhibits growth and expression of extracellular matrix in human intestinal and rat colonic smooth muscle cells. Gastroenterology 1999; 116: A948(Abstract).
    • (1999) Gastroenterology , vol.116
    • Zeeh, J.M.1    Riley, N.E.2    Hoffmann, P.3    Goebell, H.4    Gerken, G.5
  • 72
    • 0033003888 scopus 로고    scopus 로고
    • Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease
    • 72 Neurath MF, Wanitschke R, Peters M, Krummenauer F, Meyer zum Buschenfelde KH, Schlaak JF. Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease [see comments]. Gut 1999; 44: 625-8.
    • (1999) Gut , vol.44 , pp. 625-628
    • Neurath, M.F.1    Wanitschke, R.2    Peters, M.3    Krummenauer, F.4    Meyer Zum Buschenfelde, K.H.5    Schlaak, J.F.6
  • 73
    • 0033022146 scopus 로고    scopus 로고
    • Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort
    • 75 Silverstein MD, Loftus EV, Sandborn WJ, et al. Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort. Gastroenterology 1999; 117: 49-57.
    • (1999) Gastroenterology , vol.117 , pp. 49-57
    • Silverstein, M.D.1    Loftus, E.V.2    Sandborn, W.J.3
  • 74
    • 0027198002 scopus 로고
    • Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists
    • 74 Mohler KM, Torrance DS, Smith CA, et al. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol 1993; 151: 1548-61.
    • (1993) J Immunol , vol.151 , pp. 1548-1561
    • Mohler, K.M.1    Torrance, D.S.2    Smith, C.A.3
  • 75
    • 0028811230 scopus 로고
    • Effects of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration
    • 75 Suffredini AF, Reda D, Banks SM, Tropea M, Agosti JM, Miller R. Effects of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration. J Immunol 1995; 155: 5038-45.
    • (1995) J Immunol , vol.155 , pp. 5038-5045
    • Suffredini, A.F.1    Reda, D.2    Banks, S.M.3    Tropea, M.4    Agosti, J.M.5    Miller, R.6
  • 76
    • 0013511183 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
    • 76 Moreland LW, Baumgartner SW, Schiff MH, et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein [see comments]. N Engl J Med 1997; 337: 141-7.
    • (1997) N Engl J Med , vol.337 , pp. 141-147
    • Moreland, L.W.1    Baumgartner, S.W.2    Schiff, M.H.3
  • 77
    • 0033574147 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial
    • 77 Moreland LW, Schiff MH, Baumgartner SW, et al. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med 1999; 130: 478-86.
    • (1999) Ann Intern Med , vol.130 , pp. 478-486
    • Moreland, L.W.1    Schiff, M.H.2    Baumgartner, S.W.3
  • 78
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • 78 Weinblatt ME, Kremer JM, Bankhurst AD, et al. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate [see comments]. N Engl J Med 1999; 340: 253-9.
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 79
    • 0033018740 scopus 로고    scopus 로고
    • Therapeutic antibodies elicited by immunization against TNF-alpha
    • 79 Dalum I, Butler DM, Jensen MR, et al. Therapeutic antibodies elicited by immunization against TNF-alpha. Nat Biotechnol 1999; 17: 666-9.
    • (1999) Nat Biotechnol , vol.17 , pp. 666-669
    • Dalum, I.1    Butler, D.M.2    Jensen, M.R.3
  • 80
    • 0030925172 scopus 로고    scopus 로고
    • Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease
    • 80 Bauditz J, Haemling J, Ortner M, Lochs H, Raedler A, Schreiber S. Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease [see comments]. Gut 1997; 40: 470-4.
    • (1997) Gut , vol.40 , pp. 470-474
    • Bauditz, J.1    Haemling, J.2    Ortner, M.3    Lochs, H.4    Raedler, A.5    Schreiber, S.6
  • 81
    • 0025282043 scopus 로고
    • Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
    • 81 Han J, Thompson P, Beutler B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J Exp Med 1990; 172: 391-4.
    • (1990) J Exp Med , vol.172 , pp. 391-394
    • Han, J.1    Thompson, P.2    Beutler, B.3
  • 82
    • 0029758257 scopus 로고    scopus 로고
    • Rediscovering thalidomide: A review of its mechanism of action, side effects, and potential uses
    • 82 Tseng S, Pak G, Washenik K, Pomeranz MK, Shupack JL. Rediscovering thalidomide: a review of its mechanism of action, side effects, and potential uses. J Am Acad Dermatol 1996; 35: 969-79.
    • (1996) J Am Acad Dermatol , vol.35 , pp. 969-979
    • Tseng, S.1    Pak, G.2    Washenik, K.3    Pomeranz, M.K.4    Shupack, J.L.5
  • 83
    • 4243387494 scopus 로고    scopus 로고
    • Efficacy of Thalidomide in Crohn's Disease
    • Abstract
    • 83 Wedel S, Bauditz J, Suk A, Lochs H. Efficacy of Thalidomide in Crohn's Disease. Gastroenterology 1999; 116: 3665(Abstract).
    • (1999) Gastroenterology , vol.116 , pp. 3665
    • Wedel, S.1    Bauditz, J.2    Suk, A.3    Lochs, H.4
  • 84
    • 0032714405 scopus 로고    scopus 로고
    • An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease
    • 84 Vasiliauskas EA, Kam LY, Abreu-Martin MT, et al. An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease [see comments]. Gastroenterology 1999; 117: 1278-87.
    • (1999) Gastroenterology , vol.117 , pp. 1278-1287
    • Vasiliauskas, E.A.1    Kam, L.Y.2    Abreu-Martin, M.T.3


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