Ethanol exposure enhances cell death in the developing cerebral cortex: Role of brain-derived neurotrophic factor and its signaling pathways

Journal of Neuroscience Research

Volumn 68, Issue 2, 2002, Pages 213-225

  Climent, E ^a   Pascual, M ^b   Renau Piqueras, J ^a   Guerri, C ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Brain derived neurotrophic factor; Cell death; Cerebral cortex development; Fetal alcohol syndrome; TrkB receptors

Indexed keywords

ALCOHOL; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN INJURY; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; EXPOSURE; FEMALE; LACTATION; NONHUMAN; POSTNATAL DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYNAPSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGING; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CASPASES; CELL DEATH; CEREBRAL CORTEX; ENZYME ACTIVATION; ETHANOL; FEMALE; MITOGEN-ACTIVATED PROTEIN KINASES; NECROSIS; PEPTIDE FRAGMENTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; RECEPTOR, TRKB; SIGNAL TRANSDUCTION;

EID: 0036216238     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10208     Document Type: Article

References (58)

1. Regulation of neurotrophin receptors during the maturation of the mammalian visual system
2. Effect of tissue processing on colloidal gold cytochemistry
3. Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA
4. Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system
5. Cell survival promoted by the ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
6. A rapid an sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
7. Ethanol-induced neural crest cell apoptosis is coincident with their endogenous death, but is mechanistically distinct
8. Ethanol induces Fas/Apo [apoptosis]-1 mRNA and cell suicide in the developing cerebral cortex
9. Single step method of RNA isolation by acid guanidium thyocyanate-phenol-chloroform extraction
10. The fetal alcohol syndrome
11. Brain malformations related to prenatal exposure to ethanol
12. Sampling designs for stereology
13. p1B15: A cDNA clone of the rat mRNA encoding cyclophilin
14. In vivo activation and in situ BDNF-stimulated nuclear translocation of mitogen-activated/extracellular signal-regulated protein kinase is inhibited by ethanol in the developing rat hippocampus
15. Naturally occurring truncated TrkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling
16. Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derives neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y
17. CREB couples neurotrophin signals to survival messages
18. Developmental and mature expression of full-length and truncated TrkB receptors in the rat forebrain
19. Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo
20. Neuroanatomical and neurophysiological mechanisms involved in central nervous system dysfunctions induced by prenatal alcohol exposure
21. Alcohol, astroglia and brain development
22. Alcohol and acetaldehyde in rat's milk following ethanol administration
23. +-mediated cell survival
24. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway
25. Neurotrophic factor protection against ethanol toxicity in rat cerebellar granule cell cultures requires phosphatidylinositol 3-kinase activation
26. Ethanol-induced cell death in cultured rat astroglia
27. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome
28. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3′-kinase-protein kinase B signaling
29. Rgulated neurotrophin receptor responsiveness during neuronal migration and early differentiation
30. Evidence for large-scale astrocyte death in the developing crebellum
31. Temporal patterns of poly (ADP-ribose) polymerase activation in the cortex following experimental brain injury in the rat
32. Cleavage of poly (ADO-ribose) polymerase by a proteinase with properties like ICE
33. Cellular responses to DNA damage in the absence of poly(ADO-ribose) polymerase
34. Animal models of chronic ethanol toxicity
35. Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum
36. Spatiotemporal selective effects on brain-derived neurotrophic factor and trkB messenger RNA in rat hippocampus by electroconvulsive shock
37. The c-erbalfa protooncogene induces apoptosis in glial cells via a protein kinase C- and bcl-2-suppressible mechanism
38. Growth factor-mediated neural proliferation: Target of ethanol toxicity
39. A review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol
40. Glial-derived neurotrophic factor (GDNF) prevents ethanol-induced apoptosis and JUN kinase phophorylation
41. trkB, a neural receptor protein-tyrosine kinase: Evidence for a full-length and two truncated receptors
42. The effects of prenatal exposure to ethanol on cell proliferation and neuronal migration
43. Effect of pre- or postnatal exposure to ethanol on the total number of neurons in the principal sensory nucleus of the trigeminal nerve: Cell proliferation and neuronal death
44. Effects of prenatal exposure to ethanol on callosal projection neurons in rat somatosensory cortex
45. Alcohol exposure alters the expression pattern of neural cell adhesion molecules during brain development
46. Expression of bcl-2, bax, and caspase-3 in the brain of the developing rat
47. Effects of prenatal exposure to ethanol on the expression of bcl-2 bax and caspase 3 in the developing rat cerebral cortex thalamus
48. Cell death during development of the nervous system
49. Neurotrophins as synaptic modulators
50. Programmed cell death and the control of cell survival: Lessons from the nervous system
51. Mediation by a CPEB family transcription factor of NGF-dependent survival of sympathetic neurons
52. BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex
53. Liver necrosis: Cellular mechanisms and clinical implications
54. The effects of chronic alcohol consumption on pregnant rats and their offspring
55. Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells
56. Maternal drinking during pregnancy: Attention and shot-term memory in 14-year-old offspring a longitudinal prospective study
57. Prenatal exposure to ethanol induces changes in the nerve growth factor and its receptor in proliferating astrocytes in primary culture
58. Stereological techniques