NMR and molecular modelling studies of the binding of amicetin antibiotic to conserved secondary structural motifs of 23S ribosomal RNAs

Journal of Antibiotics

Volumn 59, Issue 3, 2006, Pages 177-183

  Donarski, James ^a   Shammas, Christos ^a   Banks, Ryan ^a   Ramesh, Vasudevan ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Amicetin; CD spectroscopy; Escherichia coli 23S ribosomal RNA; Halobacterium halobium 23S ribosomal RNA; Molecular modelling; NMR spectroscopy; Peptidyl transferase centre

Indexed keywords

AMICETIN; ANTIBIOTIC AGENT; ENZYME INHIBITOR; PEPTIDYLTRANSFERASE; PROTON; RIBOSOME RNA; SINGLE STRANDED RNA; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CONFORMATION; CONTROLLED STUDY; DRUG BINDING; ESCHERICHIA COLI; HALOBACTERIUM SALINARUM; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; RNA BINDING; RNA STABILITY; RNA STRUCTURE; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; TITRIMETRY;

ANTI-BACTERIAL AGENTS; CIRCULAR DICHROISM; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PYRIMIDINE NUCLEOSIDES; RNA, RIBOSOMAL, 23S;

ESCHERICHIA COLI; HALOBACTERIUM SALINARUM;

EID: 33646365637     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2006.25     Document Type: Article

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