-
1
-
-
19944427851
-
Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer
-
AMANN, J., KALYANKRISHNA, S., MASSION, P.P., OHM, J.E., GIRARD, L., SHIGEMATSU, H., PEYTON, M., JUROSKE, D., HUANG, Y., SALMON, J.S., et al. (2005). Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res. 65, 226-235.
-
(2005)
Cancer Res.
, vol.65
, pp. 226-235
-
-
Amann, J.1
Kalyankrishna, S.2
Massion, P.P.3
Ohm, J.E.4
Girard, L.5
Shigematsu, H.6
Peyton, M.7
Juroske, D.8
Huang, Y.9
Salmon, J.S.10
-
2
-
-
10844268011
-
Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474
-
ARAO, T., FUKUMOTO, H., TAKEDA, M., TAMURA, T., SAIJO, N., and NISHIO, K. (2004). Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474. Cancer Res. 64, 9101-9104.
-
(2004)
Cancer Res.
, vol.64
, pp. 9101-9104
-
-
Arao, T.1
Fukumoto, H.2
Takeda, M.3
Tamura, T.4
Saijo, N.5
Nishio, K.6
-
3
-
-
0037429728
-
Ligand-independent oncogenic signaling by the epidermal growth factor receptor: V-ErbB as a paradigm
-
BOERNER, J.L., DANIELSEN, A., and MAIHLE, N.J. (2003). Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm. Exp. Cell Res. 284, 111-121.
-
(2003)
Exp. Cell Res.
, vol.284
, pp. 111-121
-
-
Boerner, J.L.1
Danielsen, A.2
Maihle, N.J.3
-
4
-
-
0023663896
-
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells
-
DI FIORE, P.P., PIERCE, J.H., FLEMING, T.P., HAZAN, R., ULLRICH, A., KING, C.R., SCHLESSINGER, J., and AARONSON, S.A. (1987). Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell 51, 1063-1070.
-
(1987)
Cell
, vol.51
, pp. 1063-1070
-
-
Di Fiore, P.P.1
Pierce, J.H.2
Fleming, T.P.3
Hazan, R.4
Ullrich, A.5
King, C.R.6
Schlessinger, J.7
Aaronson, S.A.8
-
5
-
-
14844366111
-
Erb-B3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
-
ENGELMAN, J.A., JANNE, P.A., MERMEL, C., PEARLBERG, J., MUKOHARA, T., FLEET, C., CICHOWSKI, K., JOHNSON, B.E., and CANTLEY, L.C. (2005). Erb-B3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc. Natl. Acad. Sci. USA 102, 3788-3793.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3788-3793
-
-
Engelman, J.A.1
Janne, P.A.2
Mermel, C.3
Pearlberg, J.4
Mukohara, T.5
Fleet, C.6
Cichowski, K.7
Johnson, B.E.8
Cantley, L.C.9
-
6
-
-
0012381722
-
Multi-institutional randomised phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
FUKUOKA, M., YANO, S., GIACCONEi, G., TAMURA, T., NAKAGAWA, K., DOUILLARD, J.Y., NISHIWAKI, Y., VANSTEENKISTE, J., KUDOH, S., RISCHIN, D., et al. (2003). Multi-institutional randomised phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 21, 2237-2246.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giacconei, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
-
7
-
-
28444478439
-
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
-
GREULICH, H., CHEN, T.H., FENG, W., JANNE, P.A., ALVAREZ, J.V., ZAPPATERRA, M., BULMER, S.E., FRANK, D.A., HAHN, W.C., SELLERS, W.R., et al. (2005). Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2, e313.
-
(2005)
PLoS Med.
, vol.2
-
-
Greulich, H.1
Chen, T.H.2
Feng, W.3
Janne, P.A.4
Alvarez, J.V.5
Zappaterra, M.6
Bulmer, S.E.7
Frank, D.A.8
Hahn, W.C.9
Sellers, W.R.10
-
8
-
-
0037079003
-
Rules for making human tumor cells
-
HAHN, W.C., and WEINBERG, R.A. (2002). Rules for making human tumor cells. N. Engl. J. Med. 347, 1593-1603.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 1593-1603
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
9
-
-
0037674465
-
Epidermal growth factor family of receptors in preneoplasia and lung cancer: Perspectives for targeted therapies
-
HIRSCH, F.R., SCAGLIOTTI, G.V., LANGER, C.J., VARELLA-GARCIA, M., and FRANKLIN, W.A. (2003). Epidermal growth factor family of receptors in preneoplasia and lung cancer: Perspectives for targeted therapies. Lung Cancer 41, S29-S42.
-
(2003)
Lung Cancer
, vol.41
-
-
Hirsch, F.R.1
Scagliotti, G.V.2
Langer, C.J.3
Varella-Garcia, M.4
Franklin, W.A.5
-
10
-
-
0037429737
-
Epidermal growth factor receptor: Mechanisms of activation and signalling
-
JORISSEN, R.N., WALKER, F., POULIOT, N., GARRETT, T.P., WARD, C.W., and BURGESS, A.W. (2003). Epidermal growth factor receptor: Mechanisms of activation and signalling. Exp. Cell Res. 284, 31-53.
-
(2003)
Exp. Cell Res.
, vol.284
, pp. 31-53
-
-
Jorissen, R.N.1
Walker, F.2
Pouliot, N.3
Garrett, T.P.4
Ward, C.W.5
Burgess, A.W.6
-
11
-
-
0024395587
-
Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts
-
KOKAI, Y., MYERS, J.N., WADA, T., BROWN, V.I., LEVEA, C.M., DAVIS, J.G., DOBASHI, K., and GREENE, M.I. (1989). Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 58, 287-292.
-
(1989)
Cell
, vol.58
, pp. 287-292
-
-
Kokai, Y.1
Myers, J.N.2
Wada, T.3
Brown, V.I.4
Levea, C.M.5
Davis, J.G.6
Dobashi, K.7
Greene, M.I.8
-
12
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
KOSAKA, T., YATABE, Y., ENDOH, H., KUWANO, H., TAKAHASHI, T., and MITSUDOMI, T. (2004). Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications. Cancer Res. 64, 8919-8923.
-
(2004)
Cancer Res.
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Kuwano, H.4
Takahashi, T.5
Mitsudomi, T.6
-
14
-
-
2442482627
-
Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme
-
LEARN, C.A., HARTZELL, T.L., WIKSTRAND, C.J., ARCHER, G.E., RICH, J.N., FRIEDMAN, A.H., FRIEDMAN, H.S., BIGNER, D.D., and SAMPSON, J.H. (2004). Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. Clin. Cancer Res. 10, 3216-3224.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3216-3224
-
-
Learn, C.A.1
Hartzell, T.L.2
Wikstrand, C.J.3
Archer, G.E.4
Rich, J.N.5
Friedman, A.H.6
Friedman, H.S.7
Bigner, D.D.8
Sampson, J.H.9
-
15
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
LYNCH, T.J., BELL, D.W., SORDELLA, R., GURUBHAGAVATULA, S., OKIMOTO, R.A., BRANNIGAN, B.W., HARRIS, P.L., HASERLAT, S.M., SUPKO, J.G., HALUSKA, F.G., et al. (2004). Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
-
16
-
-
0029666423
-
Transformational and altered signal transduction by a naturally occurring mutant EGF receptor
-
MOSCATELLO, D.K., MONTGOMERY, R.B., SUNDARESHAN, P., MCDANEL, H., WONG, M.Y., and WONG, A.J. (1996). Transformational and altered signal transduction by a naturally occurring mutant EGF receptor. Oncogene 13, 85-96.
-
(1996)
Oncogene
, vol.13
, pp. 85-96
-
-
Moscatello, D.K.1
Montgomery, R.B.2
Sundareshan, P.3
McDanel, H.4
Wong, M.Y.5
Wong, A.J.6
-
17
-
-
0034778447
-
EGFR and cancer prognosis
-
NICHOLSON, R.I., GEE, J.M., and HARPER, M.E. (2001). EGFR and cancer prognosis. Eur. J. Cancer 37, S9-S15
-
(2001)
Eur. J. Cancer
, vol.37
-
-
Nicholson, R.I.1
Gee, J.M.2
Harper, M.E.3
-
18
-
-
0038324367
-
Expression of constitutively activated EGFRvIII in non-small cell lung cancer
-
OKAMOTO, I., KENYON, L.C., EMLET, D.R., MORI, T., SASAKI, J., HIROSAKO, S., ICHIKAWA, Y., KISHI, H., GODWIN, A.K., YOSHIOKA, M., et al. (2003). Expression of constitutively activated EGFRvIII in non-small cell lung cancer. Cancer Sci. 94, 50-56.
-
(2003)
Cancer Sci.
, vol.94
, pp. 50-56
-
-
Okamoto, I.1
Kenyon, L.C.2
Emlet, D.R.3
Mori, T.4
Sasaki, J.5
Hirosako, S.6
Ichikawa, Y.7
Kishi, H.8
Godwin, A.K.9
Yoshioka, M.10
-
19
-
-
0034600849
-
The ErbB signaling network: Receptor heterodimerization in development and cancer
-
OLAYIOYE, M.A., NEVE, R.M., LANE, H.A., and HYNES, N.E. (2000). The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J. 19, 3159-3167.
-
(2000)
EMBO J.
, vol.19
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
Lane, H.A.3
Hynes, N.E.4
-
20
-
-
15144341822
-
Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: Implications for subdomain contributions to receptor assembly
-
O'ROURKE, D.M., NUTE, E.J., DAVIS, J.G., WU, C., LEE, A., MURALI, R., ZHANG, H.T., QIAN, X., KAO, C.C., and GREENE, M.I. (1998). Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: Implications for subdomain contributions to receptor assembly. Oncogene 16, 1197-1207.
-
(1998)
Oncogene
, vol.16
, pp. 1197-1207
-
-
O'Rourke, D.M.1
Nute, E.J.2
Davis, J.G.3
Wu, C.4
Lee, A.5
Murali, R.6
Zhang, H.T.7
Qian, X.8
Kao, C.C.9
Greene, M.I.10
-
21
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
PAEZ, J.G., JANNE, P.A., LEE, J.C., TRACY, S., GREULICH, H., GABRIEL, S., HERMAN, P., KAYE, F.J., LINDEMAN, N., BOGGON, T.J., et al. (2004). EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304, 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
-
22
-
-
0027170451
-
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
-
PAGES, G., LENORMAND, P., L'ALLEMAIN, G., CHAMBARD, J.C., MELOCHE, S., and POUYSSEGUR, J. (1993). Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. USA 90, 8319-8323.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8319-8323
-
-
Pages, G.1
Lenormand, P.2
L'Allemain, G.3
Chambard, J.C.4
Meloche, S.5
Pouyssegur, J.6
-
23
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
PAO, W., MILLER, V., ZAKOWSKI, M., DOHERTY, J., POLITI, K., SARKARIA, I., SINGH, B., HEELAN, R., RUSCH, V., FULTON, L., et al. (2004). EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl. Acad. Sci. USA 101, 13306-13311.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
-
24
-
-
0004228474
-
Variants of 3T3 cells lacking mitogenic response to epidermal growth factor
-
PRUSS, R.M., and HERSCHMAN, H.R. (1977). Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. Proc. Natl. Acad. Sci. USA 74, 3918-3921.
-
(1977)
Proc. Natl. Acad. Sci. USA
, vol.74
, pp. 3918-3921
-
-
Pruss, R.M.1
Herschman, H.R.2
-
25
-
-
33644895399
-
Dimerization and the signal transduction pathway of a small in-frame deletion in the epidermal growth factor receptor
-
SAKAI, K., ARAO, T., SHIMOYAMA, T., MUROFUSHI, K., SEKIJIMA, M., KAJI, N., TAMURA, T., SAIJO, N., and NISHIO, K. (2006). Dimerization and the signal transduction pathway of a small in-frame deletion in the epidermal growth factor receptor. FASEB J. 20, 311-313.
-
(2006)
FASEB J.
, vol.20
, pp. 311-313
-
-
Sakai, K.1
Arao, T.2
Shimoyama, T.3
Murofushi, K.4
Sekijima, M.5
Kaji, N.6
Tamura, T.7
Saijo, N.8
Nishio, K.9
-
26
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
SCHLESSINGER, J. (2000). Cell signaling by receptor tyrosine kinases. Cell 103, 211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
27
-
-
10344258041
-
Targeting the mitogen-activated protein kinase cascade to treat cancer
-
SEBOLT-LEOPOLD, J.S., and HERRERA, R. (2004). Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat. Rev. Cancer 4, 937-947.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 937-947
-
-
Sebolt-Leopold, J.S.1
Herrera, R.2
-
28
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
SORDELLA, R., BELL, D.W., HABER, D.A., and SETTLEMAN, J. (2004). Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305, 1163-1167.
-
(2004)
Science
, vol.305
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
Settleman, J.4
-
29
-
-
5644293135
-
Gefitinib induces apoptosis in the EGFR L858R non-small-cell lung cancer cell line H3255
-
TRACY, S., MUKOHARA, T., HANSEN, M., MEYERSON, M., JOHNSON, B.E., and JANNE, P.A. (2004). Gefitinib induces apoptosis in the EGFR L858R non-small-cell lung cancer cell line H3255. Cancer Res. 64, 7241-7244.
-
(2004)
Cancer Res.
, vol.64
, pp. 7241-7244
-
-
Tracy, S.1
Mukohara, T.2
Hansen, M.3
Meyerson, M.4
Johnson, B.E.5
Janne, P.A.6
-
30
-
-
0021273420
-
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
-
ULLRICH, A., COUSSENS, L., HAYFLICK, J.S., DULL, T.J., GRAY, A., TAM, A.W., LEE, J., YARDEN, Y., LIBERMANN, T.A., SCHLESSINGER, J., et al. (1984). Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309, 418-425.
-
(1984)
Nature
, vol.309
, pp. 418-425
-
-
Ullrich, A.1
Coussens, L.2
Hayflick, J.S.3
Dull, T.J.4
Gray, A.5
Tam, A.W.6
Lee, J.7
Yarden, Y.8
Libermann, T.A.9
Schlessinger, J.10
-
31
-
-
0023595325
-
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene
-
VELU, T.J., BEGUINOT, L., VASS, W.C., WILLINGHAM, M.C., MERLINO, G.T., PASTAN, I., and LOWY, D.R. (1987). Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Science 238, 1408-1410.
-
(1987)
Science
, vol.238
, pp. 1408-1410
-
-
Velu, T.J.1
Beguinot, L.2
Vass, W.C.3
Willingham, M.C.4
Merlino, G.T.5
Pastan, I.6
Lowy, D.R.7
-
32
-
-
0025194462
-
Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function
-
WADA, T., QIAN, X.L., and GREENE, M.I. (1990). Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function. Cell 61, 1339-1347.
-
(1990)
Cell
, vol.61
, pp. 1339-1347
-
-
Wada, T.1
Qian, X.L.2
Greene, M.I.3
|