Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity

Journal of Applied Physiology

Volumn 100, Issue 4, 2006, Pages 1204-1209

  Sheel, A William ^a   Koehle, Michael S ^a   Guenette, Jordan A ^a   Foster, Glen E ^a   Sporer, Benjamin C ^a   Diep, Tu T ^a   McKenzie, Donald C ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Control of breathing; Exercise; Hypoxic ventilatory response

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ADULT; AEROBIC CAPACITY; ARTICLE; ATHLETE; CONTROLLED STUDY; ENDURANCE; EXERCISE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LUNG MINUTE VOLUME; LUNG VENTILATION; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY FUNCTION;

ADULT; ANOXIA; EXERCISE; HUMANS; MALE; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PULMONARY VENTILATION;

EID: 33646362045     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01127.2005     Document Type: Article

References (33)

1. Brutsaert TD, Parra EJ, Shriver MD, Gamboa A, Rivera-Ch M, and Leon-Velarde F. Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives. Am J Physiol Regul Integr Comp Physiol 289: R225-R234, 2005.
2. Byrne-Quinn E, Weil JV, Sodal IE, Filley GF, and Grover RF. Ventilatory control in the athlete. J Appl Physiol 30: 91-98, 1971.
3. 2 during heavy exercise. J Appl Physiol 62: 199-207, 1987.
4. Dempsey JA. Is the lung built for exercise? Med Sci Sports Exerc 18: 143-155, 1986.
5. Dempsey JA, Forster HV, and Ainsworth DM. Regulation of hyperpnea, hyperventilation, and respiratory muscle recruitment during exercise. In: Regulation of Breathing, edited by Dempsey JA and Pack AI. New York: Dekker, 1995, p. 1065-1134.
6. Derchak PA, Stager JM, Tanner DA, and Chapman RF. Expiratory flow limitation confounds ventilatory response during exercise in athletes. Med Sci Sports Exerc 32: 1873-1879, 2000.
7. Ferretti G. Extreme human breath-hold diving. Eur J Appl Physiol 84: 254-271, 2001.
8. Foster GE, McKenzie DC, Milsom WK, and Sheel AW. Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. J Physiol 567: 689-699, 2005.
9. Guenette JA, Diep TT, Koehle MS, Foster GE, Richards JC, and Sheel AW. Acute hypoxic ventilatory response and exercise-induced arterial hypoxemia in men and women. Respir Physiol Neurbiol 143: 37-48, 2004.
10. Harms CA and Stager JM. Low chemoresponsiveness and inadequate hyperventilation contribute to exercise-induced hypoxemia. J Appl Physiol 79: 575-580, 1995.
11. Hopkins SR and McKenzie DC. Hypoxic ventilatory response and arterial desaturation during heavy work. J Appl Physiol 67: 1119-1124, 1989.
12. Katayama K, Sato Y, Morotome Y, Shima N, Ishida K, Mori S, and Miyamura M. Ventilatory chemosensitive adaptations to intermittent hypoxic exposure with endurance training and detraining. J Appl Physiol 86: 1805-1811, 1999.
13. Koehle MS, Foster GE, McKenzie DC, and Sheel AW. Repeated measurement of hypoxic ventilatory response as an intermittent hypoxic stimulus. Respir Physiol Neurobiol 145: 33-39, 2005.
14. Leitch AG. Chemical control of breathing in identical twin athletes. Ann Hum Biol 3: 447-454, 1976.
15. Leitch AG, Clancy L, and Flenley DC. Maximal oxygen uptake, lung volume and ventilatory response to carbon dioxide and hypoxia in a pair of identical twin athletes. Clin Sci Mol Med 48: 235-238, 1975.
16. Levine BD, Friedman DB, Engfred K, Hanel B, Kjaer M, Clifford PS, and Secher NH. The effect of normoxic or hypobaric hypoxic endurance training on the hypoxic ventilatory response. Med Sci Sports Exerc 24: 769-775, 1992.
17. Li YL, Li YF, Liu D, Cornish KG, Patel KP, Zucker IH, Channon KM, and Schultz HD. Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits. Circ Res 97: 260-267, 2005.
18. Martin BJ, Sparks KE, Zwillich CW, and Weil JV. Low exercise ventilation in endurance athletes. Med Sci Sports Exerc 11: 181-185, 1979.
19. Martin BJ, Wiel JV, Sparks KE, McCullough RE, and Grover RF. Exercise ventilation correlates positively with ventilatory chemoresponsiveness. J Appl Physiol 45: 557-564, 1978.
20. Masuyama S, Kimura H, Sugita T, Kuriyama T, Tatsumi K, Kunitomo F, Okita S, Tojima H, Yuguchi Y, Watanabe S, et al. Control of ventilation in extreme-altitude climbers. J Appl Physiol 61: 500-506, 1986.
21. Miyachi M and Tabata I. Relationship between arterial oxygen desaturation and ventilation during maximal exercise. J Appl Physiol 73: 2588-2591, 1992.
22. Pan LG, Forster HV, Bisgard GE, Lowry CL, and Murphy TF. Independence of exercise hyperpnea and acidosis during high intensity exercise in ponies. J Appl Physiol 60: 1016-1024, 1986.
23. Schoene RB. Control of ventilation in climbers to extreme altitude. J Appl Physiol 53: 886-896, 1982.
24. Scoggin CH, Doekel RD, Kryger MH, Zwillich CW, and Weil JV. Familial aspects of decreased hypoxic drive in endurance athletes. J Appl Physiol 44: 464-468, 1978.
25. Sheel AW, Coutts KD, Potts JE, and McKenzie DC. The time course of pulmonary diffusing capacity for carbon monoxide following short duration high intensity exercise. Respir Physiol 111: 271-281, 1998.
26. Sun SY, Wang L, Wang W, Zucker IH, and Schultz HD. Exercise training normalizes enhanced peripheral chemoreflex function in rabbits with heart failure (Abstract). FASEB J 13: A444, 1999.
27. Sun SY, Wang W, Zucker IH, and Schultz HD. Enhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide. J Appl Physiol 86: 1273-1282, 1999.
28. Wagner PD. Determinants of maximal oxygen transport and utilization. Annu Rev Physiol 58: 21-50, 1996.
29. 2 max. Exerc Sport Sci Rev 28: 10-14, 2000.
30. Wagner PD. Why doesn't exercise grow the lungs when other factors do? Exerc Sport Sci Rev 33: 3-8, 2005.
31. Weil JV. Variation in human ventilatory control-genetic influence on the hypoxic ventilatory response. Respir Physiol Neurobiol 135: 239-246, 2003.
32. Weil JV and Swanson GD. Peripheral chemoreceptors and the control of breathing. In: Exercise, Pulmonary Physiology and Pathophysiology, edited by Whipp BJ and Wasserman K. New York: Dekker, 1991, p. 371-403.
33. Zhang S and Robbins PA. Methodological and physiological variability within the ventilatory response to hypoxia in humans. J Appl Physiol 88: 1924-1932, 2000.