Acute hypoxic ventilatory response and exercise-induced arterial hypoxemia in men and women

Respiratory Physiology and Neurobiology

Volumn 143, Issue 1, 2004, Pages 37-48

  Guenette, Jordan A ^a   Diep, Tu T ^a   Koehle, Michael S ^a   Foster, Glen E ^a   Richards, Jennifer C ^a   Sheel, A William ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Arterial oxygen saturation; Elite athlete; Exercise; Hypoxic ventilatory response; Ventilation

Indexed keywords

OXYGEN; OXYHEMOGLOBIN;

ARTICLE; BREATHING; CARBON DIOXIDE BLOOD LEVEL; CHEMOSENSITIVITY; CONTROLLED STUDY; CYCLING; ENDURANCE; EXERCISE; EXHAUSTION; FEMALE; GENDER; HUMAN; HUMAN EXPERIMENT; HYPOXEMIA; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; OXYGEN SATURATION; PRIORITY JOURNAL; SEX DIFFERENCE; TRAINING;

ADULT; ANOXEMIA; ANOXIA; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; MALE; OXYGEN; OXYGEN CONSUMPTION; PHYSICAL FITNESS; RESPIRATORY FUNCTION TESTS; RESPIRATORY PHYSIOLOGY; SEX FACTORS;

EID: 5144229053     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2004.07.004     Document Type: Article

References (44)

1. M.L. Aitken, J.L. Franklin, D.J. Pierson, and R.B. Schoene Influence of body size and gender on control of ventilation J. Appl. Physiol. 60 1986 1894 1899
2. D.A. Bayliss, and D.E. Millhorn Central neural mechanisms of progesterone action: application to the respiratory system J. Appl. Physiol. 73 1992 393 404
3. B.A. Beidleman, P.B. Rock, S.R. Muza, C.S. Fulco, V.A. Forte Jr., and A. Cymerman Exercise VE and physical performance at altitude are not affected by menstrual cycle phase J. Appl. Physiol. 86 1999 1519 1526
4. E. Byrne-Quinn, J.V. Weil, I.E. Sodal, G.F. Filley, and R.F. Grover Ventilatory control of the athlete J. Appl. Physiol. 30 1971 91 98
5. J.A. Dempsey, P.G. Hanson, and K.S. Henderson Exercise-induced arterial hypoxaemia in healthy human subjects at sea level J. Physiol. (Lond.) 355 1984 161 175
6. J.A. Dempsey, and P.D. Wagner Exercise-induced arterial hypoxemia J. Appl. Physiol. 87 1997 2006
7. J.A. Dempsey, A.W. Sheel, H.C. Haverkamp, M.A. Babcock, and C.A. Harms Pulmonary system limitations to exercise in health Can. J. Appl. Physiol. 28 2003 2 24 (The John Sutton Lecture: CSEP 2002)
8. P.A. Derchak, J.M. Stager, D.A. Tanner, and R.F. Chapman Expiratory flow limitation confounds ventilatory response during exercise in athletes Med. Sci. Sports Exerc. 32 2000 1873 1879
9. T.P. Gavin, and J.M. Stager The effect of exercise modality on exercise-induced hypoxemia Respir. Physiol. 115 1999 317 323
10. J.E. Hansen, and R. Casaburi Validity of ear oximetry in clinical exercise testing Chest 91 1987 333 337
11. C.A. Harms, and J.M. Stager Low chemoresponsiveness and inadequate hyperventilation contribute to exercise-induced hypoxemia J. Appl. Physiol. 79 1995 575 580
12. C.A. Harms, S.R. McClaran, G.A. Nickele, D.F. Pegelow, W.B. Nelson, and J.A. Dempsey Exercise-induced arterial hypoxaemia in healthy young women J. Physiol. (Lond.) 507 1998 619 628
13. C.A. Harms, T.J. Wetter, S.R. McClaran, D.F. Pegelow, G.A. Nickele, W.B. Nelson, P. Hanson, and J.A. Dempsey Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise J. Appl. Physiol. 85 1998 609 618
14. C.A. Harms, T.J. Wetter, C.M. St Croix, D.F. Pegelow, and J.A. Dempsey Effects of respiratory muscle work on exercise performance J. Appl. Physiol. 89 2000 131 138
15. A. Holmgren, and H. Linderholm Oxygen and carbon dioxide tensions of arterial blood during heavy exercise and exhaustive exercise Acta Physiol. Scand. 44 1958 203 215
16. S.R. Hopkins, and D.C. McKenzie Hypoxic ventilatory response and arterial desaturation during heavy work J. Appl. Physiol. 67 1989 1119 1124
17. S.R. Hopkins, R.C. Barker, T.D. Brutsaert, T.P. Gavin, P. Entin, I.M. Olfert, S. Veisel, and P.D. Wagner Pulmonary gas exchange during exercise in women: effects of exercise type and work increment J. Appl. Physiol. 89 2000 721 730
18. B.D. Johnson, K.W. Saupe, and J.A. Dempsey Mechanical constraints on exercise hyperpnea in endurance athletes J. Appl. Physiol. 73 1992 874 886
19. C.M. Lebrun, D.C. McKenzie, J.C. Prior, and J.E. Taunton Effects of menstrual cycle phase on athletic performance Med. Sci. Sports Exerc. 27 1995 437 444
20. B.D. Levine, D.B. Friedman, K. Engfred, B. Hanel, M. Kjaer, P.S. Clifford, and N.H. Secher The effect of normoxic or hypobaric hypoxic endurance training on the hypoxic ventilatory response Med. Sci. Sports Exerc. 24 1992 769 775
21. B.A. Martin, J.V. Wiel, K.E. Sparks, R.E. McCullough, and R.F. Grover Exercise ventilation correlates positively with ventilatory chemoresponsiveness J. Appl. Physiol. 45 1978 557 564
22. B.J. Martin, K.E. Sparks, C.W. Zwillich, and J.V. Weil Low exercise ventilation in endurance athletes Med. Sci. Sports Exerc. 11 1979 181 185
23. D. Martin, S. Powers, M. Cicale, N. Collop, D. Huang, and D. Criswell Validity of pulse oximetry during exercise in elite endurance athletes J. Appl. Physiol. 72 1992 455 458
24. S.R. McClaran, C.A. Harms, D.F. Pegelow, and J.A. Dempsey Smaller lungs in women affect exercise hyperpnea J. Appl. Physiol. 84 1998 1872 1881
25. J. Mead Dysanapsis in normal lungs assessed by the relationship between maximal flow, static recoil, and vital capacity Am. Rev. Respir. Dis. 121 1980 339 342
26. M. Miyachi, and I. Tabata Relationship between arterial oxygen desaturation and ventilation during maximal exercise J. Appl. Physiol. 73 1992 2588 2591
27. S.K. Powers, S. Dodd, J. Lawler, G. Landry, M. Kirtley, T. McKnight, and S. Grinton Incidence of exercise induced hypoxemia in elite endurance athletes at sea level Eur. J. Appl. Physiol. 58 1988 298 302
28. S.K. Powers, S. Dodd, J. Freeman, G.D. Ayers, H. Samson, and T. McKnight Accuracy of pulse oximetry to estimate HbO2 fraction of total Hb during exercise J. Appl. Physiol. 67 1989 300 304
29. C. Prefaut, F. Anselme-Poujol, and C. Caillaud Inhibition of histamine release by nedocromil sodium reduces exercise-induced hypoxemia in master athletes Med. Sci. Sports Exerc. 29 1997 10 16
30. A.J. Rice, G.C. Scroop, C.J. Gore, A.T. Thornton, M.A.J. Chapman, H.W. Greville, M.D. Holmes, and R. Scicchitano Exercise-induced hypoxaemia in highly trained cyclists at 40% peak oxygen uptake Eur. J. Appl. Physiol. 79 1999 353 359
31. A.J. Rice, A.T. Thornton, C.J. Gore, G.C. Scroop, H.W. Greville, H. Wagner, P.D. Wagner, and S.R. Hopkins Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemia J. Appl. Physiol. 87 1999 1802 1812
32. Richards, J.C., McKenzie, D.C., Warburton, D.E.R., Road, J.D., Sheel, A.W., in press. Prevalence of exercise-induced arterial hypoxemia in healthy women. Med. Sci. Sports Exerc.
33. S.A. Sahn, C.W. Zwillich, N. Dick, R.E. McCullough, S. Lakshminarayan, and J.V. Weil Variability of ventilatory responses to hypoxia and hypercapnia J. Appl. Physiol. 43 1977 1019 1025
34. R.B. Schoene, H.T. Robertson, D.J. Pierson, and A.P. Peterson Respiratory drives and exercise in menstrual cycles of athletic and nonathletic women J. Appl. Physiol. 50 1981 1300 1305
35. C.H. Scoggin, R.D. Doekel, M.H. Kryger, C.W. Zwillich, and J.V. Weil Familial aspects of decreased hypoxic drive in endurance athletes J. Appl. Physiol. 44 1978 464 468
36. A.W. Sheel, P.A. Derchak, B.J. Morgan, D.F. Pegelow, A.J. Jacques, and J.A. Dempsey Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans J. Physiol. (Lond.) 537 2001 277 289
37. R.J. Smyth, A.D. D'Urzo, A.S. Slutsky, B.M. Galko, and A.S. Rebuck Ear oximetry during combined hypoxia and exercise J. Appl. Physiol. 60 1986 716 719
38. K. Tatsumi, C.K. Pickett, C.R. Jacoby, J.V. Weil, and L.G. Moore Role of endogenous female hormones in hypoxic chemosensitivity J. Appl. Physiol. 83 1997 1706 1710
39. W.M. Thurlbeck Postnatal human lung growth Thorax 37 1982 564 571
40. J. Walls, M. Maskrey, R. Wood-Baker, and W. Stedman Exercise-induced oxyhaemoglobin desaturation, ventilatory limitation and lung diffusing capacity in women during and after exercise Eur. J. Appl. Physiol. 87 2002 145 152
41. J.V. Weil, E. Byrne-Quinn, I.E. Sodal, W.O. Friesen, B. Underhill, G.F. Filley, and R.F. Grover Hypoxic ventilatory drive in normal man J. Clin. Invest. 49 1970 1061 1072
42. T.J. Wetter, Z. Xiang, D.A. Sonetti, H.C. Haverkamp, A.J. Rice, A.A. Abbasi, K.C. Meyer, and J.A. Dempsey Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes J. Appl. Physiol. 93 2002 116 126
43. D.P. White, N.J. Douglas, C.K. Pickett, J.V. Weil, and C.W. Zwillich Sexual influence on the control of breathing J. Appl. Physiol. 54 1983 874 879
44. S. Zhang, and P.A. Robbins Methodological and physiological variability within the ventilatory response to hypoxia in humans J. Appl. Physiol. 88 1924 1932