Ventilatory chemosensitive adaptations to intermittent hypoxic exposure with endurance training and detraining

Journal of Applied Physiology

Volumn 86, Issue 6, 1999, Pages 1805-1811

  Katayama, Keisho ^a   Sato, Yasutake ^a   Morotome, Yoshifumi ^a   Shima, Norihiro ^a   Ishida, Koji ^a   Mori, Shigeo ^a   Miyamura, Miharu ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Altitude training; Hypercapnic ventilatory chemosensitivity; Hypoxic ventilatory chemosensitivity

Indexed keywords

ADULT; ALTITUDE ACCLIMATIZATION; ANAEROBIC THRESHOLD; ARTICLE; BREATHING MECHANICS; BREATHING REFLEX; CHEMOSENSITIVITY; ENDURANCE; EXERCISE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; HYPOXIA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATION CONTROL;

EID: 0032994928     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.6.1805     Document Type: Article

References (43)

1. O2 independent of ventilatory acclimatization at 4,300 m. J. Appl. Physiol. 66: 2733-2738, 1989.
2. 2 saturation during maximal exercise in acute hypoxia. Eur. J. Appl. Physiol. 72: 101-105, 1995.
3. Benoit, H., M. Germain, J. C. Barthelemy, C. Denis, J. Castells, D. Dormois, J. R. Lacour, and A. Geyssant. Preacclimatization to high altitude using exercise with normobaric hypoxic gas mixtures. Int. J. Sports Med. 13, Suppl: S213-S216, 1992.
4. Bradley, B. L., J. Mestas, J. Forman, and K. M. Unger. The effect on respiratory drive of a prolonged physical conditioning program. Am. Rev. Respir. Dis. 122: 741-746, 1980.
5. Byrne-Quinn, E., J. V. Weil, I. E. Sodal, G. F. Filley, and R. F. Grover. Ventilatory control in the athlete. J. Appl. Physiol. 30: 91-98, 1971.
6. Chua, T. P., and A. J. S. Coats. The reproducibility and comparability of tests of the peripheral chemoreflex: comparing the transient hypoxic ventilatory drive test and the single-breath carbon dioxide response test in healthy subjects. Eur. J. Clin. Invest. 25: 887-892, 1995.
7. 2 in chronic airways obstruction measured by a rebreathing method. Clin. Sci. (Colch.) 34: 559-568, 1968.
8. Davies, C. T. M., and A. J. Sargeant. Effects of hypoxic training on normoxic maximal aerobic power output. Eur. J. Appl. Physiol. 33: 227-236, 1974.
9. Davis, J. A., M. H. Frank, B. J. Whipp, and K. Wasserman. Anaerobic threshold alterations caused by endurance training in middle-aged men. J. Appl. Physiol. 46: 1039-1046, 1979.
10. Desplanches, D., H. Hoppeler, M. T. Linossier, C. Denis, H. Claassen, D. Dormois, J. R. Lacour, and A. Geyssant. Effects of training in normoxia and normobaric hypoxia on human muscle ultrastructure. Eur. J. Pediatr. 425: 263-267, 1993.
11. O2max and endurance are not enhanced by acute hypobaric exposure. Eur. J. Appl. Physiol. 76: 8-12, 1997.
12. Forster, H. V., J. A. Dempsey, M. L. Birnbaum, W. G. Reddan, J. Thoden, R. F. Grover, and J. Rankin. Effect of chronic exposure to hypoxia on ventilatory response to CO2 and hypoxia. J. Appl. Physiol. 31: 586-592, 1971.
13. +] at chemoreceptors of man. J. Appl. Physiol. 39: 292-296, 1975.
14. Hackett, P. H., and O. Oelz. The Lake Louise consensus on the definition and quantification of altitude illness. In: Hypoxia and Mountain Medicine, edited by J. R. Sutton, G. Coates, and C. S. Houston. Burlington, VT: Queen City Printers, 1992, p. 327-330.
15. Houston, C. S. Operation Everest one and two. Respiration 64: 398-406, 1997.
16. Katayama, K., Y. Sato, K. Ishida, S. Mori, and M. Miyamura. The effects of intermittent exposure to hypoxia during endurance exercise training on the ventilatory responses to hypoxia and hypercapnia in humans. Eur. J. Appl. Physiol. 78: 189-194, 1998.
17. 2 ventilatory response test. J. Appl. Physiol. 68: 393-399, 1990.
18. Kronenberg, R., F. N. Hamilton, R. Gabel, R. Hickey, D. J. C. Read, and J. Severinghaus. Comparison of three methods for quantitating respiratory response to hypoxia in man. Respir. Physiol. 16: 109-125, 1972.
19. Levine, B. D., D. B. Friedman, K. Engfred, B. Hanel, M. Kjaer, P. S. Clifford, and N. H. Secher. The effect of normoxic or hypobaric hypoxic endurance training on the hypoxic ventilatory response. Med. Sci. Sports Exerc. 24: 769-775, 1992.
20. Martin, B. J., K. E. Sparks, C. W. Zwillich, and J. V. Weil. Low exercise ventilation in endurance athletes. Med. Sci. Sports Exerc. 11: 181-185, 1979.
21. Martin, B. J., J. V. Weil, K. E. Sparks, R. E. McCullough, and R. F. Grover. Exercise ventilation correlates positively with ventilatory chemoresponsiveness. J. Appl. Physiol. 45: 557-564, 1978.
22. Mathew, L., P. M. Gopinathan, S. S. Purkayastha, J. S. Gupta, and H. S. Nayer. Chemoreceptor sensitivity in adaptation to high altitude. Aviat. Space Environ. Med. 54: 121-126, 1983.
23. 2 as a clinical test of the peripheral chemoreflex. J. Appl. Physiol. 64: 84-89, 1988.
24. McConnell, A. K., and E. S. G. Semple. Ventilatory sensitivity to carbon dioxide: the influence of exercise and athleticism. Med. Sci. Sports Exerc. 28: 685-691, 1996.
25. McConnell, A. K., E. S. G. Semple, and C. T. M. Davies. Ventilatory responses to exercise and carbon dioxide in elderly and younger humans. Eur. J. Appl. Physiol. 66: 332-337, 1993.
26. Melissa, L., J. D. MacDougall, M. A. Tarnopolsky, N. Cipriano, and H. J. Green. Skeletal muscle adaptations to training under normobaric hypoxic versus normoxic conditions. Med. Sci. Sports Exerc. 29: 238-243, 1997.
27. Miyamura, M., and K. Ishida. Adaptive changes in hypercap-nic ventilatory response during training and detraining. Eur. J. Appl. Physiol. 60: 353-359, 1990.
28. 2 by oligomycin and by antimycin A. Am. J. Physiol. 242 (Cell Physiol. 11): C200-C206, 1982.
29. Neufer, P. D. The effect of detraining and reduced training on the physiological adaptations to aerobic exercise training. Sports Med. 8: 302-321, 1989.
30. 2 chemoreflex from rest to exercise. Eur. J. Appl. Physiol. 70: 360-366, 1995.
31. Read, D. J. C. A clinical method for assessing the ventilatory response to carbon dioxide. Aust. Ann. Med. 16: 20-32, 1967.
32. 2 relationships and ventilation during rebreathing. J. Appl. Physiol. 23: 53-70, 1967.
33. Ready, A. E., and H. A. Quinney. Alterations in anaerobic threshold as the result of endurance training and detraining. Med. Sci. Sports Exerc. 14: 292-296, 1982.
34. Sato, M., J. W. Severinghaus, and P. Bickler. Time course of augmentation and depression of hypoxic ventilatory response at altitude. J. Appl. Physiol. 77: 313-316, 1994.
35. Sato, M., J. W. Severinghaus, F. L. Powell, F. D. Xu, and M. J. Spellman, Jr. Augmented hypoxic ventilatory response in men at altitude. J. Appl. Physiol. 73: 101-107, 1992.
36. Schoene, R. B. Control of ventilation in climbers to extreme altitude. J. Appl. Physiol. 53: 886-890, 1982.
37. Schoene, R. B. Control of breathing at high altitude. Respiration 64: 407-415, 1997.
38. Schoene, R. B., R. C. Roach, P. H. Hackett, J. R. Sutton, A. Cymerman, and C. S. Houston. Operation Everest: ventilatory adaptation during gradual decompression to extreme altitude. Med. Sci. Sports Exerc. 22: 804-810, 1990.
39. Scoggin, C. H., R. D. Doekel, M. H. Kryger, C. W. Zwillich, and J. V. Weil. Familial aspects of decreased hypoxic drive in endurance athletes. J. Appl. Physiol. 44: 464-468, 1978.
40. 2 in normal man at sea level and high altitude. J. Appl. Physiol. 27: 186-190, 1969.
41. Weil, J. V., E. Byrne-Quinn, I. E. Sodal, W. O. Friesen, B. Underhill, G. F. Filley, and R. F. Grover. Hypoxic ventilatory drive in normal man. J. Clin. Invest. 49: 1061-1072, 1970.
42. Weil, J. V., E. Byrne-Quinn, I. E. Sodal, J. S. Kline, R. E. McCullough, and G. F. Filley. Augmentation of chemosensitivity during mild exercise in normal man. J. Appl. Physiol. 33: 813-819, 1972.
43. White, D. P., K. Gleeson, C. K. Pickett, A. M. Rannels, A. Cymerman, and J. V. Weil. Altitude acclimatization: influence on periodic breathing and chemoresponsiveness during sleep. J. Appl. Physiol. 63: 401-412, 1987.